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Journal of Neural Transmission

Erschienen in:

01.07.2009 | Basic Neurosciences, Genetics and Immunology - Original Article

Functional gene variants of the serotonin-synthesizing enzyme tryptophan hydroxylase 2 in migraine

verfasst von: Martin Marziniak, Claudia Kienzler, Gregor Kuhlenbäumer, Claudia Sommer, Rainald Mössner

Erschienen in: Journal of Neural Transmission | Ausgabe 7/2009

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Abstract

Serotonin (5-HT) plays an important role in the pathophysiology of migraine. Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of 5-HT in the brain and is therefore a major factor in the availability of 5-HT and its rate of production. We hypothesized that functional TPH2 gene variants are associated with migraine. In a case–control study approach, two proven functional and two putatively functional variants of the TPH2 gene were investigated in 266 migraine patients and 153 controls. Genotype, allele, and haplotype frequencies did not differ between healthy subjects and migraineurs. A subgroup analysis for the occurrence of aura or clinical characteristics, including the number of attacks, did not reveal a positive association for the investigated polymorphisms. Our data argue against a major influence of the TPH2 gene promoter region in migraine.

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Titel: Functional gene variants of the serotonin-synthesizing enzyme tryptophan hydroxylase 2 in migraine
verfasst von: Martin Marziniak
Claudia Kienzler
Gregor Kuhlenbäumer
Claudia Sommer
Rainald Mössner
Publikationsdatum: 01.07.2009
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 7/2009
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-009-0236-7

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