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Erschienen in: Archives of Virology 1/2017

01.10.2016 | Annotated Sequence Record

Molecular characterization of a new human coxsackievirus B2 associated with severe hand-foot-mouth disease in Yunnan Province of China in 2012

verfasst von: Jie Zhang, Haihao Zhang, Yilin Zhao, Chen Guo, Zhaoqing Yang, Shaohui Ma

Erschienen in: Archives of Virology | Ausgabe 1/2017

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Abstract

Human coxsackievirus B2 (CVB2) belongs to the species Human enterovirus B and can cause aseptic meningitis, myocarditis and hand-foot-mouth disease (HFMD). We first determined the complete genome of the RW41-2/YN/CHN/2012 strain, isolated from a patient with HFMD and aseptic meningitis in the Yunnan Province, China in 2012. The strain shared 83.5 % and 82.2 % nucleotide similarity with CVB2 prototype strain Ohio-1, in the complete VP1 gene and the complete genome, respectively. Using phylogenetic and homogeneity analyses for the complete VP1 gene, CVB2 strains could be divided into four genogroups (A–D); the RW41-2/YN/CHN/2012 strain belonging to genogroup D. The amino acid sequence of VP1 is highly conserved. Recombination analyses showed the newly isolated RW41-2/YN/CHN/2012 strain was probably a recombinant, which was closely related to strain CVB2 (KM386639) in the genomic P1 and P2 regions and strains of other human enterovirus B (HEV-B) viruses (KT353721, JX644073, and KP262053) in the P3 region.
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Metadaten
Titel
Molecular characterization of a new human coxsackievirus B2 associated with severe hand-foot-mouth disease in Yunnan Province of China in 2012
verfasst von
Jie Zhang
Haihao Zhang
Yilin Zhao
Chen Guo
Zhaoqing Yang
Shaohui Ma
Publikationsdatum
01.10.2016
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 1/2017
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-016-3075-5

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