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Clinical Rheumatology

Erschienen in:

01.09.2015 | Review Article

Non-canonical manifestations of familial Mediterranean fever: a changing paradigm

verfasst von: Donato Rigante, Giuseppe Lopalco, Giusyda Tarantino, Adele Compagnone, Michele Fastiggi, Luca Cantarini

Erschienen in: Clinical Rheumatology | Ausgabe 9/2015

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Abstract

Paroxysmal crises of fever and systemic inflammation herald familial Mediterranean fever (FMF), considered as the archetype of all inherited systemic autoinflammatory diseases. Inflammatory bouts are characterized by short-term and self-limited abdominal, thoracic, and/or articular symptoms which subside spontaneously. Erysipelas-like findings, orchitis, and different patterns of myalgia may appear in a minority of patients. In recent years, many non-classical manifestations have been reported in the clinical context of FMF, such as vasculitides and thrombotic manifestations, neurologic and sensory organ abnormalities, gastrointestinal diseases, and even macrophage activation syndrome. As FMF left unrecognized and untreated is ominously complicated by the occurrence of AA-amyloidosis, it is highly desirable that diagnosis of this autoinflammatory disorder with its multiple clinical faces can be contemplated at whatever age and brought forward.

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Titel: Non-canonical manifestations of familial Mediterranean fever: a changing paradigm
verfasst von: Donato Rigante
Giuseppe Lopalco
Giusyda Tarantino
Adele Compagnone
Michele Fastiggi
Luca Cantarini
Publikationsdatum: 01.09.2015
Verlag: Springer London
Erschienen in: Clinical Rheumatology / Ausgabe 9/2015
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-015-2916-z

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