nach oben

Neurological Sciences

Erschienen in:

01.01.2013 | Brief Communication

Predictive index for the onset of medication overuse headache in migraine patients

verfasst von: T. Onaya, M. Ishii, H. Katoh, S. Shimizu, H. Kasai, M. Kawamura, Y. Kiuchi

Erschienen in: Neurological Sciences | Ausgabe 1/2013

Einloggen, um Zugang zu erhalten

Abstract

Migraine patients are particularly prone to develop medication overuse headache (MOH). However, the risk factors for the transformation of migraine to MOH are still not clear. We investigated gene polymorphisms, personality traits, and characteristics of headache and lifestyle in 47 migraine patients (aged 36.4 ± 10.3) and 22 MOH patients (aged 39.6 ± 9.9) who progressed from migraine and made a scoring system for a predictive index (PI) of the onset of MOH in patients with migraine. By multivariate logistic stepwise regression analysis, type of migraine, regular and sufficient dietary intake, and methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) and dopamine D2 receptor (DRD2) C939T (rs6275) polymorphisms were selected as significant factors that contribute independently to the development from migraine to MOH (P < 0.05). The regression coefficients (β) of these four selected factors were approximated and scored. The PI score in MOH patients (7.32 ± 1.60) was significantly higher than that in migraine patients (4.62 ± 1.83, P < 0.001). The proposed scoring system should in the future be the object of larger studies to confirm its validity.

HeadacheClassification Committee, Olesen J, Bousser MG, Diener HC, Dodick D, First M, Goadsby PJ, Göbel H, Lainez MJ, Lance JW, Lipton RB, Nappi G, Sakai F, Schoenen J, Silberstein SD, Steiner TJ (2006) New appendix criteria open for a broader concept of chronic migraine. Cephalalgia 26:742–746PubMedCrossRef

Imai N, Kitamura E, Konishi T, Suzuki Y, Serizawa M, Okabe T (2007) Clinical features of probable medication-overuse headache: a retrospective study in Japan. Cephalalgia 27:1020–1023PubMedCrossRef

Kanki R, Nagaseki Y, Sakai F (2008) Medication-overuse headache in Japan. Cephalalgia 28:1227–1228PubMedCrossRef

Sakai F, Igarashi H (1997) Prevalence of migraine in Japan: a nationwide survey. Cephalalgia 17:15–22PubMedCrossRef

Meskunas CA, Tepper SJ, Rapoport AM, Sheftell FD, Bigal ME (2006) Medications associated with probable medication overuse headache reported in a tertiary care headache center over a 15-year period. Headache 46:766–772PubMedCrossRef

Fanciullacci M, Cesaris FD (2005) Preventing chronicity of migraine. J Headache Pain 6:331–333PubMedCrossRef

Ferrari A, Leone S, Valeria A (2007) Similarities and differences between chronic migraine and episodic migraine. Headache 47:65–72PubMedCrossRef

Lewis DW (2002) Migraine headache in the adolescent. Adolesc Med 13:413–432PubMed

Molarius A, Tegelberg A, Ohrvik J (2008) Socio-economic factors, lifestyle, and headache disorders: a population-based study in Sweden. Headache 48:1426–1437PubMedCrossRef

10.

Kaji Y, Hirata K (2009) Characteristics of mood disorders in Japanese patients with medication-overuse headache. Inter Med 48:981–986CrossRef

11.

Bienvenu OJ, Nestadt G, Samuels JF, Costa PT, Howard WT, Eaton WW (2001) Phobic, panic, and major depressive disorders and the five-factor model of personality. J Nerv Ment Dis 189:154–161PubMedCrossRef

12.

Park JW, Kim JS, Kim YI, Lee KS (2005) Serotonergic activity contributes to analgesic overuse in chronic tension-type headache. Headache 45:1229–1235PubMedCrossRef

13.

Cevoli S, Marzocchi N, Capellari S, Scapoli C, Pierangeli G, Grimaldi D, Naldi F, Pini LA, Montagna P, Cortelli P (2010) Lack of association between five serotonin metabolism-related genes and medication overuse headache. J Headache Pain 11:53–58PubMedCrossRef

14.

Terrazzino S, Sances G, Balsamo F, Viana M, Monaco F, Bellomo G, Martignoni E, Tassorelli C, Nappi G, Canonico PL, Genazzani AA (2010) Role of 2 common variants of 5HT2A gene in medication overuse headache. Headache 50:1587–1596PubMedCrossRef

15.

Headache Classification Subcommittee of the International Headache Society (2004) The international classification of headache disorders: 2nd edition. Cephalalgia 24(Suppl 1):9–160

16.

American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Washington American Psychiatric Association Press

17.

Costa PT Jr, McCrae RR (1992) Revised NEO personality inventory (NEO-PI-R) and NEO five-factor inventory (NEO-FFI) professional manual. Psychol Assess Resour, Odessa

18.

Murakami F, Shimomura T, Kotani K, Ikawa S, Nanba E, Adachi K (1999) Anxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese. J Hum Genet 44:15–17PubMedCrossRef

19.

Kaiser R, Muller-Oerlinghausen B, Filler D, Tremblay PB, Berghofer A, Roots I, Brockmoller J (2002) Correlation between serotonin uptake in human blood platelets with the 44-bp polymorphism and the 17-bp variable number of tandem repeat of the serotonin transporter. Am J Med Genet 114:323–328PubMedCrossRef

20.

Joober R, Benkelfat C, Brisebois K, Toulouse A, Turecki G, Lal S, Bloom D, Labelle A, Lalonde P, Fortin D, Alda M, Palmour R, Rouleau GA (1999) T102 polymorphism in the 5-HT_2A gene and schizophrenia: relation to phenotype and drug response variability. J Psychiatry Neurosci 24:141–146PubMed

21.

MaassenVanDenBrink A, Vergouwe MN, Ophoff RA, Saxena PR, Ferrari MD, Frants RR (1998) 5-HT_1B receptor polymorphism and clinical response to sumatriptan. Headache 38:288–291PubMedCrossRef

22.

Deckert J, Catalano M, Syagailo YV, Bosi M, Okladnova O, Di Bella D, Nöthen MM, Maffei P, Franke P, Fritze J, Maier W, Propping P, Beckmann H, Bellodi L, Lesch KP (1999) Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet 8:621–624PubMedCrossRef

23.

Guo G, Ou XM, Roettger M, Shih JC (2008) The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity. Eur J Hum Genet 16:626–634PubMedCrossRef

24.

Hotamisligil GS, Breakefield XO (1991) Human monoamine oxidase A gene determines levels of enzyme activity. Am J Hum Genet 49:383–392PubMed

25.

Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, Rozen R (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10:111–113PubMedCrossRef

26.

Rigat B, Hubert C, Corvol P, Soubrier F (1992) PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res 20:1433PubMedCrossRef

27.

Colson NJ, Lea RA, Quinlan S, Griffiths LR (2006) No role for estrogen receptor 1 gene intron 1 Pvu II and exon 4 C325G polymorphisms in migraine susceptibility. BMC Med Genet 7:12PubMedCrossRef

28.

Curran JE, Lea RA, Rutherford S, Weinstein SR, Griffiths LR (2001) Association of estrogen receptor and glucocorticoid receptor gene polymorphisms with sporadic breast cancer. Int J Cancer 95:271–275PubMedCrossRef

29.

Sarkar G, Kapelner S, Grandy DK, Marchionni M, Civelli O, Sobell J, Heston L, Sommer SS (1991) Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor. Genomics 11:8–14PubMedCrossRef

30.

Shin S, Stewart R, Ferri CP, Kim JM, Shin IS, Kim SW, Yang SJ, Yoon JS (2010) An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5-HTTLPR and MTHFR genes in order Korean men. Int J Geriatr Psychiatry 25:441–448PubMedCrossRef

31.

Kimura K, Iguchi Y, Shibazaki K, Junya A, Terasawa Y (2008) Hemorrhagic transformation of ischemic brain tissue after t-PA thrombolysis as detected by MRI may be asymptomatic, but impair neurological recovery. J Neurol Sci 272:136–142PubMedCrossRef

32.

Lee TC, Wang HP, Chiu HM, Lien WC, Chen MJ, Yu LC, Sun CT, Lin JT, Wu MS (2010) Male gender and renal dysfunction are predictors of adverse outcome in nonpostoperative ischemic colitis patients. J Clin Gastroenterol 44:e96–e100PubMedCrossRef

33.

Ishii M, Sakairi Y, Hara H, Imagawa A, Shimizu S, Takahashi J, Nagamine A, Naito Y, Masuda Y, Usami S, Kiuchi Y (2011) Negative predictors of clinical response to triptans in patients with migraine. Neurol Sci. doi:10.1007/s10072-011-0716-z

34.

Blount BC, Mack MM, Wehr CM, MacGregor JT, Hiatt RA, Wang G, Wickramasinghe SN, Everson RB, Ames BN (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 94:3290–3295PubMedCrossRef

35.

Duthie SJ, Narayanan S, Brand GM, Pirie L, Grant G (2002) Impact of folate deficiency on DNA stability. J Nutr 132(Suppl):2444S–2449SPubMed

36.

de Bree A, Verschuren WM, Bjorke-Monsen AL, van der Put NM, Heil SG, Trijbels FJ, Blom HJ (2003) Effect of the methylenetetrahydrofolate reductase 677C–>T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample. Am J Clin Nutr 77:687–693PubMed

37.

Miller AL (2008) The methylation, neurotransmitter, and antioxidant connections between folate and depression. Altern Med Rev 13:216–226PubMed

38.

Koslow SH, Butler IJ (1977) Biogenic amine synthesis defect in dihydropteridine reductase deficiency. Science 198:522–523PubMedCrossRef

39.

Hering R, Glover V, Pattichis K, Catarci T, Steiner TJ (1993) 5HT in migraine patients with medication-induced headache. Cephalalgia 13:410–412PubMedCrossRef

40.

Rossi C, Pini LA, Cupini ML, Calabresi P, Sarchielli P (2008) Endocannabinoids in platelets of chronic migraine patients and medication-overuse headache patients: relation with serotonin levels. Eur J Clin Pharmacol 64:1–8PubMedCrossRef

41.

D’Andrea G, Granella F, Perini F, Farruggio A, Leone M, Bussone G (2006) Platelet levels of dopamine are increase in migraine and cluster headache. Headache 46:585–591PubMedCrossRef

42.

Calabresi P, Cupini LM (2005) Medication-overuse headache: similarities with drug addiction. Trends Pharmacol Sci 26:62–68PubMedCrossRef

43.

Peroutka SJ, Wilhoit T, Jones K (1997) Clinical susceptibility to migraine with aura is modified by dopamine D2 receptor (DRD2) NcoI alleles. Neurology 49:201–206PubMedCrossRef

44.

Gilbody S, Lewis S, Lightfoot T (2007) Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review. Am J Epidemiol 165:1–13PubMedCrossRef

45.

Peroutka SJ, Price SC, Wilhoit TL, Jones KW (1998) Comorbid migraine with aura, anxiety, and depression is associated with dopamine D2 receptor (DRD2) NcoI alleles. Mol Med 4:14–21PubMed

Titel: Predictive index for the onset of medication overuse headache in migraine patients
verfasst von: T. Onaya
M. Ishii
H. Katoh
S. Shimizu
H. Kasai
M. Kawamura
Y. Kiuchi
Publikationsdatum: 01.01.2013
Verlag: Springer Milan
Erschienen in: Neurological Sciences / Ausgabe 1/2013
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-012-0955-7

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2013

Serum carnitine levels and levocarnitine supplementation in institutionalized Huntington’s disease patients

Risk of seizures during intraoperative electrocortical stimulation of brain motor areas: a retrospective study on 50 patients

Message from the Editor-in-Chief

Sleep architecture impairment in epileptic children and putative role of anti epileptic drugs

Event-related potentials to changes of rhythmic unit: differences between musicians and nonmusicians