Skip to main content
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases 4/2004

01.04.2004 | Article

Epidemiology of Candidaemia in Europe: Results of 28-Month European Confederation of Medical Mycology (ECMM) Hospital-Based Surveillance Study

verfasst von: A. M. Tortorano, J. Peman, H. Bernhardt, L. Klingspor, C. C. Kibbler, O. Faure, E. Biraghi, E. Canton, K. Zimmermann, S. Seaton, R. Grillot, the ECMM Working Group on Candidaemia

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 4/2004

Einloggen, um Zugang zu erhalten

Abstract

In order to update the epidemiological and mycological profile of candidaemia in Europe, the European Confederation of Medical Mycology conducted a prospective, sequential, hospital population-based study from September 1997 to December 1999. A total of 2,089 cases were documented by 106 institutions in seven European countries. Rates of candidaemia ranging from 0.20 to 0.38 per 1,000 admissions were reported. Candida albicans was identified in 56% of cases. Non-albicans Candida species were most frequently isolated from patients with haematological malignancies (65%). With increasing age, an increasing incidence of Candida glabrata was seen. The 30-day mortality rate was 37.9%. The survey results underline the burden of candidaemia in a wide range of patient populations, confirm the importance of non-albicans species, and provide baseline data for future surveillance studies at a European level.
Literatur
1.
Zurück zum Zitat Jarvis WR (1995) Epidemiology of nosocomial fungal infections, with emphasis on Candida species. Clin Infect Dis 20:1526–1530PubMed Jarvis WR (1995) Epidemiology of nosocomial fungal infections, with emphasis on Candida species. Clin Infect Dis 20:1526–1530PubMed
2.
Zurück zum Zitat Edmond MB, Wallace SE, McClish DK, Pfaller MA, Jones RN,Wenzel RP (1999) Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin Infect Dis 29:239–244PubMed Edmond MB, Wallace SE, McClish DK, Pfaller MA, Jones RN,Wenzel RP (1999) Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin Infect Dis 29:239–244PubMed
3.
Zurück zum Zitat Wey SB, Mori M, Pfaller MA, Woolson RF, Wenzel RP (1988) Hospital-acquired candidemia: the attributable mortality and excess length of stay. Arch Intern Med 148:2642–2645PubMed Wey SB, Mori M, Pfaller MA, Woolson RF, Wenzel RP (1988) Hospital-acquired candidemia: the attributable mortality and excess length of stay. Arch Intern Med 148:2642–2645PubMed
4.
Zurück zum Zitat Wenzel RP, Edmond MB (2001) The impact of hospital acquired bloodstream infections. Emerg Infect Dis 7:174–177PubMed Wenzel RP, Edmond MB (2001) The impact of hospital acquired bloodstream infections. Emerg Infect Dis 7:174–177PubMed
5.
Zurück zum Zitat Pelz RK, Lipsett PA, Swoboda SM, Diener-West M, Powe NR, Brower RG, Perl TM, Hammond JM, Hendrix CW (2000) Candida infections: outcome and attributable ICU costs in critically ill patients. J Intens Care Med 15:255–261CrossRef Pelz RK, Lipsett PA, Swoboda SM, Diener-West M, Powe NR, Brower RG, Perl TM, Hammond JM, Hendrix CW (2000) Candida infections: outcome and attributable ICU costs in critically ill patients. J Intens Care Med 15:255–261CrossRef
6.
Zurück zum Zitat Kao AS, Brandt ME, Pruitt WR, Conn LA, Perkins A, Stephens DS, Baughman WS, Reingold AL, Rothrock GA, Pfaller MA, Pinner RW, Hajjeh RA (1999) The epidemiology of candidemia in two United States cities: results of a population-based active surveillance. Clin Infect Dis 29:1164–1170PubMed Kao AS, Brandt ME, Pruitt WR, Conn LA, Perkins A, Stephens DS, Baughman WS, Reingold AL, Rothrock GA, Pfaller MA, Pinner RW, Hajjeh RA (1999) The epidemiology of candidemia in two United States cities: results of a population-based active surveillance. Clin Infect Dis 29:1164–1170PubMed
7.
Zurück zum Zitat Sandven P (2000) Epidemiology of candidemia. Rev Iberoam Micol 17:73–81 Sandven P (2000) Epidemiology of candidemia. Rev Iberoam Micol 17:73–81
8.
Zurück zum Zitat Pfaller MA, Diekema DJ (2002) Role of sentinel surveillance of candidemia: trends in species distribution and antifungal susceptibility. J Clin Microbiol 40:3551–3557CrossRefPubMed Pfaller MA, Diekema DJ (2002) Role of sentinel surveillance of candidemia: trends in species distribution and antifungal susceptibility. J Clin Microbiol 40:3551–3557CrossRefPubMed
9.
Zurück zum Zitat Launay O, Lortholary O, Bouges-Michel C, Jarrousse B, Bentata M, Guillevin L (1998) Candidemia: a nosocomial complication in adults with late-stage AIDS. Clin Infect Dis 26:1134–1141PubMed Launay O, Lortholary O, Bouges-Michel C, Jarrousse B, Bentata M, Guillevin L (1998) Candidemia: a nosocomial complication in adults with late-stage AIDS. Clin Infect Dis 26:1134–1141PubMed
10.
Zurück zum Zitat Tumbarello M, Tacconelli E, De Gaetano Donati K, Morace G, Fadda G, Cauda R (1999) Candidemia in HIV-infected subjects. Eur J Clin Microbiol lnfect Dis 18:478–483CrossRef Tumbarello M, Tacconelli E, De Gaetano Donati K, Morace G, Fadda G, Cauda R (1999) Candidemia in HIV-infected subjects. Eur J Clin Microbiol lnfect Dis 18:478–483CrossRef
11.
Zurück zum Zitat Viscoli C, Girmenia C, Marinus A, Collette L, Martino P, Vandercam B, Doyen C, Lebau B, Spence D, Krcmery V, De Pauw B, Meunier F (1999) Candidemia in cancer patients: a prospective, multicenter surveillance study by the Invasive Fungal Infection Group (IFIG) of the European Organization for Research and Treatment of Cancer (EORTC). Clin lnfect Dis 28:1071–1079 Viscoli C, Girmenia C, Marinus A, Collette L, Martino P, Vandercam B, Doyen C, Lebau B, Spence D, Krcmery V, De Pauw B, Meunier F (1999) Candidemia in cancer patients: a prospective, multicenter surveillance study by the Invasive Fungal Infection Group (IFIG) of the European Organization for Research and Treatment of Cancer (EORTC). Clin lnfect Dis 28:1071–1079
12.
Zurück zum Zitat Richet H, Roux P, Des Champs C, Esnault Y, Andremont A; French candidemia study group (2002) Candidemia in French hospitals: incidence rates and characteristics. Clin Microbiol Infect 8:405–412CrossRefPubMed Richet H, Roux P, Des Champs C, Esnault Y, Andremont A; French candidemia study group (2002) Candidemia in French hospitals: incidence rates and characteristics. Clin Microbiol Infect 8:405–412CrossRefPubMed
13.
Zurück zum Zitat Grillot R (1997) Epidemiological survey of candidemia in Europe. ECMM Mycology Newsletter 0/97:12–14 Grillot R (1997) Epidemiological survey of candidemia in Europe. ECMM Mycology Newsletter 0/97:12–14
14.
Zurück zum Zitat Donelly SM, Sullivan DJ, Shanley DB, Coleman DC (1999) Phylogenetic analysis and rapid identification of Candida dubliniensis based on analysis of ACT1 intron and exon sequences. Microbiology 145:1871–1882PubMed Donelly SM, Sullivan DJ, Shanley DB, Coleman DC (1999) Phylogenetic analysis and rapid identification of Candida dubliniensis based on analysis of ACT1 intron and exon sequences. Microbiology 145:1871–1882PubMed
15.
Zurück zum Zitat Marot-Leblond A, Grimaud L, Nail S, Bouterige S, Apaire-Marchais V, Sullivan DJ, Robert R (2000) New monoclonal antibody specific for Candida albicans germ tube. J Clin Microbiol 38:61–67PubMed Marot-Leblond A, Grimaud L, Nail S, Bouterige S, Apaire-Marchais V, Sullivan DJ, Robert R (2000) New monoclonal antibody specific for Candida albicans germ tube. J Clin Microbiol 38:61–67PubMed
16.
Zurück zum Zitat Ascioglu S, Rex JH, de Pauw B, Bennett JE, Bille J, Crokaert F, Denning DW, Donelly JP, Edwards JE, Erjavec Z, Fiere D, Lortholary O, Maertens J, Meiss JF, Patterson TF, Ritter J, Selleslag D, Shah PM, Stevens DA, Walsh TJ (2002) Defining oportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic cell transplants: an international consensus. Clin Infect Dis 34:7–14PubMed Ascioglu S, Rex JH, de Pauw B, Bennett JE, Bille J, Crokaert F, Denning DW, Donelly JP, Edwards JE, Erjavec Z, Fiere D, Lortholary O, Maertens J, Meiss JF, Patterson TF, Ritter J, Selleslag D, Shah PM, Stevens DA, Walsh TJ (2002) Defining oportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic cell transplants: an international consensus. Clin Infect Dis 34:7–14PubMed
17.
Zurück zum Zitat Bernhardt H, Zimmermann K, Sissolak D, Schutt-Gerwitt H, Schroder G, Enzensberger R, Willinger B, Weig M, Berns G, Grisold A, Seewald M, Ziegler E, Ruchel R, Burkhardt S, Sommer B, Graf B, Jahn B, Asboth F, Meyer L (2000) Epidemiological survey on candidemia in Europe: results of Germany and Austria. Rev Iberoam Micol 17 (Suppl 3):146–147 Bernhardt H, Zimmermann K, Sissolak D, Schutt-Gerwitt H, Schroder G, Enzensberger R, Willinger B, Weig M, Berns G, Grisold A, Seewald M, Ziegler E, Ruchel R, Burkhardt S, Sommer B, Graf B, Jahn B, Asboth F, Meyer L (2000) Epidemiological survey on candidemia in Europe: results of Germany and Austria. Rev Iberoam Micol 17 (Suppl 3):146–147
18.
Zurück zum Zitat Grillot R, Faure O, Fruit J, Sendid B, Rispail P, Datry A, Biava MF, Kures L, Morin O, Toubas D, Bretagne S, Bouteille B, Lebau B, Cassaing S, Cuisenier B, Grawey I, Poirot JL, Eloy O, Kauffmann-Lacrooix C, de Champs C, Kac G, Lavarde V, Baixench M, Bougnoux ME, Lachaud L, Lamy C, Pellet E, Biondi C (2000) ECMM prospective epidemiological survey of candidemia in Europe: report from France. Rev Iberoam Micol 17 (Suppl 3):144 Grillot R, Faure O, Fruit J, Sendid B, Rispail P, Datry A, Biava MF, Kures L, Morin O, Toubas D, Bretagne S, Bouteille B, Lebau B, Cassaing S, Cuisenier B, Grawey I, Poirot JL, Eloy O, Kauffmann-Lacrooix C, de Champs C, Kac G, Lavarde V, Baixench M, Bougnoux ME, Lachaud L, Lamy C, Pellet E, Biondi C (2000) ECMM prospective epidemiological survey of candidemia in Europe: report from France. Rev Iberoam Micol 17 (Suppl 3):144
19.
Zurück zum Zitat Klingspor L, Tornquist E, Johansson A, Petrini B, Forsum U, Hedin G (2000) ECMM’s survey of candidemia in Europe: report from Sweden. Rev Iberoam Micol 17 (Suppl 3):147 Klingspor L, Tornquist E, Johansson A, Petrini B, Forsum U, Hedin G (2000) ECMM’s survey of candidemia in Europe: report from Sweden. Rev Iberoam Micol 17 (Suppl 3):147
20.
Zurück zum Zitat Pemán J, Cantón E, Orero A, Viudes A, Frasquet J, Gobernado M (2002) Estudio multicentrico sobre la epidemiologia de las candidemias en Espana. Rev Iberoam Micol 19:30–35PubMed Pemán J, Cantón E, Orero A, Viudes A, Frasquet J, Gobernado M (2002) Estudio multicentrico sobre la epidemiologia de las candidemias en Espana. Rev Iberoam Micol 19:30–35PubMed
21.
Zurück zum Zitat Tortorano AM, Biraghi E, Astolfi A, Ossi C, Tejada M, Farina C, Perin S, Bonaccorso C, Cavanna C, Raballo A, Grossi A, the FIMUA candidemia study group (2002) European Confederation of Medical Mycology (ECMM) prospective survey of candidaemia: report from one Italian region. J Hosp Infect 51:297–304CrossRefPubMed Tortorano AM, Biraghi E, Astolfi A, Ossi C, Tejada M, Farina C, Perin S, Bonaccorso C, Cavanna C, Raballo A, Grossi A, the FIMUA candidemia study group (2002) European Confederation of Medical Mycology (ECMM) prospective survey of candidaemia: report from one Italian region. J Hosp Infect 51:297–304CrossRefPubMed
22.
Zurück zum Zitat Kibbler CC, Seaton S, Barnes RA, Gransden WR, Holliman RE, Johnson EM, Perry JD, Sullivan DJ, Wilson JA (2003) Manangement and outcome of bloostream infections due to Candida species in England and Wales. J Hosp Infect 54:18–24CrossRefPubMed Kibbler CC, Seaton S, Barnes RA, Gransden WR, Holliman RE, Johnson EM, Perry JD, Sullivan DJ, Wilson JA (2003) Manangement and outcome of bloostream infections due to Candida species in England and Wales. J Hosp Infect 54:18–24CrossRefPubMed
23.
Zurück zum Zitat Tortorano AM, Peman J, Faure O, Bernhardt H, Kibbler CC, Grillot R (2001). Bloodstream infections due to Candida species in AIDS patients: report of 63 episodes from the European Confederation of Medical Mycology (ECMM). Clin Infect Dis 33:1219 Tortorano AM, Peman J, Faure O, Bernhardt H, Kibbler CC, Grillot R (2001). Bloodstream infections due to Candida species in AIDS patients: report of 63 episodes from the European Confederation of Medical Mycology (ECMM). Clin Infect Dis 33:1219
24.
Zurück zum Zitat Tortorano AM, Peman J, Klingspor L, Bernhardt H, Kibbler C, Faure O, Biraghi E, Canton E, Zimmmermann K, Ainscough S, Grillot R (2001) Candidaemia in premature neonates. Report of 123 episodes from the ECMM working group. Mycoses 44 (Suppl 1):76 Tortorano AM, Peman J, Klingspor L, Bernhardt H, Kibbler C, Faure O, Biraghi E, Canton E, Zimmmermann K, Ainscough S, Grillot R (2001) Candidaemia in premature neonates. Report of 123 episodes from the ECMM working group. Mycoses 44 (Suppl 1):76
25.
Zurück zum Zitat Nucci M, Colombo AL, Silveira F, Richtmann R, Salomao R, Branchini ML, Spector N (1998) Risk factors for death in patients with candidemia. Infect Control Hosp Epidemiol 19:846–850PubMed Nucci M, Colombo AL, Silveira F, Richtmann R, Salomao R, Branchini ML, Spector N (1998) Risk factors for death in patients with candidemia. Infect Control Hosp Epidemiol 19:846–850PubMed
26.
Zurück zum Zitat Blumberg HM, Jarvis WR, Soucie JM, Edwards JE, Patterson JE, Pfaller MA, Rangel-Frausto MS, Rinaldi MG, Saiman L, Wiblin RT, Wenzel RP and the NEMIS Study Group (2001) Risk factors for candidal bloodstream infections in surgical intensive care unit patients: the NEMIS prospective multicenter study. Clin Infect Dis 33:177–186PubMed Blumberg HM, Jarvis WR, Soucie JM, Edwards JE, Patterson JE, Pfaller MA, Rangel-Frausto MS, Rinaldi MG, Saiman L, Wiblin RT, Wenzel RP and the NEMIS Study Group (2001) Risk factors for candidal bloodstream infections in surgical intensive care unit patients: the NEMIS prospective multicenter study. Clin Infect Dis 33:177–186PubMed
27.
Zurück zum Zitat Nucci M, Anaissie E (2001) Revisiting the source of candidemia: skin or gut? Clin Infect Dis 33:1959–1967CrossRefPubMed Nucci M, Anaissie E (2001) Revisiting the source of candidemia: skin or gut? Clin Infect Dis 33:1959–1967CrossRefPubMed
28.
Zurück zum Zitat Wingard JR (1995) Importance of Candida species other than C. albicans as pathogens in oncology patients. Clin Infect Dis 20:115–125PubMed Wingard JR (1995) Importance of Candida species other than C. albicans as pathogens in oncology patients. Clin Infect Dis 20:115–125PubMed
29.
Zurück zum Zitat Wingard JR, Dick JD, Merz WG, Sandford GR, Saral R, Burns WH (1982) Differences in virulence of clinical isolates of Candida tropicalis and Candida albicans in mice. Infect Immun 37:833–836PubMed Wingard JR, Dick JD, Merz WG, Sandford GR, Saral R, Burns WH (1982) Differences in virulence of clinical isolates of Candida tropicalis and Candida albicans in mice. Infect Immun 37:833–836PubMed
30.
Zurück zum Zitat Oude Lashof AML, Donelly JP, Meis JFGM, Meer JWM, Kullberg BJ (2003) Duration of antifungal treatment and development of delayed complications in patients with candidaemia. Eur J Clin Microbol Infect Dis 22:43–48 Oude Lashof AML, Donelly JP, Meis JFGM, Meer JWM, Kullberg BJ (2003) Duration of antifungal treatment and development of delayed complications in patients with candidaemia. Eur J Clin Microbol Infect Dis 22:43–48
31.
Zurück zum Zitat Rex JH, Walsh TJ, Sobel JD, Filler SG, Pappas PG, Dismukes WE, Edwards JE (2000) Practice guidelines for the treatment of candidiasis. Clin Infect Dis 30:662–678PubMed Rex JH, Walsh TJ, Sobel JD, Filler SG, Pappas PG, Dismukes WE, Edwards JE (2000) Practice guidelines for the treatment of candidiasis. Clin Infect Dis 30:662–678PubMed
32.
Zurück zum Zitat Walsh TJ, Rex JH (2002) All catheter-related candidemia is not the same: assessment of the balance between the risks and benefits of removal of vascular catheters. Clin Infect Dis 34:600–602PubMed Walsh TJ, Rex JH (2002) All catheter-related candidemia is not the same: assessment of the balance between the risks and benefits of removal of vascular catheters. Clin Infect Dis 34:600–602PubMed
33.
Zurück zum Zitat Wold Health Organisation (2003) Atlas of health in Europe. WHO Regional Office for Europe, Copenhagen, Denmark Wold Health Organisation (2003) Atlas of health in Europe. WHO Regional Office for Europe, Copenhagen, Denmark
Metadaten
Titel
Epidemiology of Candidaemia in Europe: Results of 28-Month European Confederation of Medical Mycology (ECMM) Hospital-Based Surveillance Study
verfasst von
A. M. Tortorano
J. Peman
H. Bernhardt
L. Klingspor
C. C. Kibbler
O. Faure
E. Biraghi
E. Canton
K. Zimmermann
S. Seaton
R. Grillot
the ECMM Working Group on Candidaemia
Publikationsdatum
01.04.2004
Erschienen in
European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 4/2004
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-004-1103-y

Weitere Artikel der Ausgabe 4/2004

European Journal of Clinical Microbiology & Infectious Diseases 4/2004 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.