Erschienen in:
14.01.2016 | Original Article
Individualized significance of the −251 A/T single nucleotide polymorphism of interleukin-8 in severe infections
verfasst von:
M. D. Georgitsi, V. Vitoros, C. Panou, I. Tsangaris, E. Aimoniotou, N. K. Gatselis, E. Chasou, G. Kouliatsis, K. Leventogiannis, D. Velissaris, E. Belesiotou, O. Dioritou-Aggaliadou, E. Giannitsioti, M. G. Netea, E. J. Giamarellos-Bourboulis, G. Giannikopoulos, Z. Alexiou, N. Voloudakis, A. Koutsoukou, on behalf of the Hellenic Sepsis Study Group
Erschienen in:
European Journal of Clinical Microbiology & Infectious Diseases
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Ausgabe 4/2016
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Abstract
Based on the concept of the individualized nature of sepsis, we investigated the significance of the −251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8.