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02.03.2017 | Original Article

Transcranial LED therapy on amyloid-β toxin 25–35 in the hippocampal region of rats

verfasst von: Camila da Luz Eltchechem, Afonso Shiguemi Inoue Salgado, Renato Amaro Zângaro, Mário César da Silva Pereira, Ivo Ilvan Kerppers, Luis Augusto da Silva, Rodolfo Borges Parreira

Erschienen in: Lasers in Medical Science | Ausgabe 4/2017

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Abstract

Excessive Aβ deposition in the brain is associated with the formation of senile plaques, and their diffuse distribution is related to Alzheimer’s disease. Thirty rats (EG) were irradiated with light-emitting diode (photobiomodulation (PBM)) in the frontal region of the skull after being inoculated with the Aβ toxin in the hippocampus; 30 rats were used as the control group (CG). The analysis was conducted at 7, 14, and 21 days after irradiation. We observed a decreased in Aβ deposits in treated animals compared with animals in the CG. The behavioral and motor assessment revealed that the EG group covered a larger ground distance and explored the open field than the CG group on days 14 and 21 (p < 0.05). The EG group was statistically significant in the spatial memory test compared to the CG group on day 14. The use of PBM significantly reduced the presence of Aβ plaques and improved spatial memory and behavioral and motor skills in treated animals on day 21.

Zheng H, Koo EH (2011) Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener 6:27CrossRefPubMedPubMedCentral

Lee VM, Goedert M, Trojanowski JQ (2001) Neurodegenerative tauopathies. Annu Rev Neurosci 24:1121–1159CrossRefPubMed

Hippius H, Neundorfer G (2003) The discovery of Alzheimer’s disease. Dialogues Clin Neurosci 5:101–108PubMedPubMedCentral

Fisher R, Maier O (2015) Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF. Oxidative Med Cell Longev 2015:610813

McGeer PL, McGeer EG (2002) Local neuroinflammation and the progression of Alzheimer’s disease. J Neurovirol 8:529–538CrossRefPubMed

Perry VH, Nicoll JAR, Holmes C (2010) Microglia in neurodegenerative disease. Nat Rev Neurol 6:193–201CrossRefPubMed

Yang H, Feng G, Liang Z, Vitale A, Jiao XY, Ju G, You SW (2012) In vitro beneficial activation of microglial cells by mechanically-injured astrocytes enhances the synthesis and secretion of BDNF through p38MAPK. Neurochem Int 6:175–186CrossRef

Haass C, Selkoe DJ (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer’s amyloid beta-peptide. Nat Rev Mol Cell Biol 8:101–112CrossRefPubMed

Heneka MT, O’Banion MK (2007) Inflammatory processes in Alzheimer’s disease. J Neuroimmunol 184:69–91CrossRefPubMed

10.

Desmet KD, Paz DA, Corry JJ, Eells JT, Wong-Riley MTT, Henry MM, Buchmann EV, Connelly MP et al (2006) Clinical and experimental applications of NIR-LED photobiomodulation. Photomed Laser Surg 24:121–128CrossRefPubMed

11.

Lane N (2006) Cell biology: power games. Nature 443:901–903CrossRefPubMed

12.

Yu W, Naim JO, McGowan M, Ippolito K, Lanzafame RJ (1997) Photomodulation of oxidative metabolism and electron chain enzymes in rat liver mitochondria. Photochem Photobiol 66:866–871CrossRefPubMed

13.

Mochizuki-Oda N, Kataoka Y, Cui Y, Yamada H, Heya M, Awazu K (2002) Effects of near-infra-red laser irradiation on adenosine triphosphate and adenosine diphosphate contents of rat brain tissue. Neurosci Lett 323:207–210CrossRefPubMed

14.

Oron U, Ilic S, De Taboada L, Streeter J (2007) Ga-As (808 nm) laser irradiation enhances ATP production in human neuronal cells in culture. Photomed Laser Surg 25:180–182CrossRefPubMed

15.

Oron A, Oron U, Chen J, Eilam A, Zhang C, Sadeh M, Lampl Y et al (2006) Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits. Stroke 37:2620–2624CrossRefPubMed

16.

Rojas J, Lee J, John J, Gonzalez-Lima F (2008) Neuroprotective effects of nearinfrared light in an in vivo model of mitochondrial optic neuropathy. J Neurosci 28:13511–13521CrossRefPubMedPubMedCentral

17.

Rojas JC, Bruchey AK, Gonzalez-Lima F (2012) Low-level light therapy improves cortical metabolic capacity and memory retention. J Alzheimers Dis 32:741–752PubMed

18.

Liang HL, Whelan HT, Eells JT, Wong-Riley MTT (2008) Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. Neuroscience 153:963–974CrossRefPubMedPubMedCentral

19.

Duan R, Zhu L, Liu TCY, Li Y, Liu J, Jiao J, Xu X, Yao L, Liu S (2003) Light emitting diode irradiation protect against the amyloid beta 25–35 induced apoptosis of PC12 cell in vitro. Lasers Surg Med 33:199–203CrossRefPubMed

20.

Sommer AP, Bieschke J, Friedrich RP, Zhu D, Wanker EE, Fecht HJ, Mereles D, Hunstein W (2012) 670 nm laser light and EGCG complementarily reduce amyloid-β aggregates in human neuroblastoma cells: basis for treatment of Alzheimer’s disease? Photomed Laser Surg 30:54–60CrossRefPubMed

21.

Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. Academic, San Diego

22.

Freir DB, Herron CE (2003) Inhibition of L-type voltage dependent calcium channels causes impairment of long-term potentiation in the hippocampal CA1 region in vivo. Brain Res 967:27–36CrossRefPubMed

23.

Walsh RN, Cummins RA (1976) The open-field test: a critical review. Psychol Bull 83:482–504CrossRefPubMed

24.

D’Hooge R, De Deyn PP (2001) Applications of the Morris water maze in the study of learning and memory. Brain Res Rev 36:60–90CrossRefPubMed

25.

Barbosa C, Teles C, Moreira L, Damião AJ, de Lima C (2012) A novel opto-mechanical system constituted by LEDs to employment in photobiostimulation: clinical application in optical therapy. Spectroscopy 27:9–18CrossRef

26.

Hashmi JT, Huang YY, Osmani BZ, Sharma SK, Naeser MA, Hamblin MR (2010) Role of low-level laser therapy in neurorehabilitation. PM R 2:S292–305CrossRefPubMedPubMedCentral

27.

Hanczyc P, Samoc M, Norden B (2013) Multiphoton absorption in amyloid protein fibres. Nat Photonics 7:969–972CrossRef

28.

Yang Z, Zhang Y, Yang Y, Sun L, Han D, Li H, Wang C (2010) Pharmacological and toxicological target organelles and safe use of single-walled carbon nanotubes as drug carriers in treating Alzheimer disease. Nanomedicine 6:427–441CrossRefPubMed

29.

Bortoletto R, Silva NS, Zângaro RA, Pacheco MTT, Da Matta RA, Pacheco-Soares C (2004) Mitochondrial membrane potential after low-power laser irradiation. Lasers Med Sci 18:204–206CrossRefPubMed

30.

Giuliani A, Lorenzini L, Gallamini M, Massella A, Giardino L, Calzà L (2009) Low infra red laser light irradiation on cultured neural cells: effects on mitochondria and cell viability after oxidative stress. BMC Complement Altern Med 9:8CrossRefPubMedPubMedCentral

31.

Sofroniew MV, Vinters HV (2010) Astrocytes: biology and pathology. Acta Neuropathol 119:7–35CrossRefPubMed

32.

Aimone JB, Deng W, Gage FH (2011) Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation. Neuron 70:589–596CrossRefPubMedPubMedCentral

33.

Costa VCI, Bueno JLO, Xavier GF (2005) Dentate gyrus-selective colchicine lesion and performance in temporal and spatial tasks. Behav Brain Res 160:286–303CrossRefPubMed

34.

Kesner RP, Hunsaker MR (2010) The temporal attributes of episodic memory. Behav Brain Res 215:299–309CrossRefPubMed

35.

Suárez-Pereira I, Canals S, Carrión AM (2015) Adult newborn neurons are involved in learning acquisition and long-term memory formation: the distinct demands on temporal neurogenesis of different cognitive tasks. Hippocampus 25:51–61CrossRefPubMed

36.

Counts SE, Alldred MJ, Che S, Ginsberg SD, Mufson EJ (2014) Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment. Neuropharmacology 79:172–179CrossRefPubMed

37.

Bueno J, Costa VI, Xavier GF, Dima L (2006) The acquisition of a temporal task (DRL) by dentate gyrus-selective colchicine lesioned rats. Psicol Reflex Crit 19:159–165CrossRef

38.

Eichenbaum H, Stewart C, Morris RG (1990) Hippocampal representation in place learning. J Neurosci 10:3531–3542PubMed

39.

Michalikova S, Ennaceur A, van Rensburg R, Chazot PL (2008) Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: effects of low infrared light. Neurobiol Learn Mem 89:480–488CrossRefPubMed

Titel: Transcranial LED therapy on amyloid-β toxin 25–35 in the hippocampal region of rats
verfasst von: Camila da Luz Eltchechem
Afonso Shiguemi Inoue Salgado
Renato Amaro Zângaro
Mário César da Silva Pereira
Ivo Ilvan Kerppers
Luis Augusto da Silva
Rodolfo Borges Parreira
Publikationsdatum: 02.03.2017
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 4/2017
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-017-2156-3

Springer Medizin

Abstract

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