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Japanese Journal of Ophthalmology

Erschienen in:

01.09.2013 | Clinical Investigation

Long-term results of treatment with diquafosol ophthalmic solution for aqueous-deficient dry eye

verfasst von: Shizuka Koh, Chikako Ikeda, Yoshihiro Takai, Hitoshi Watanabe, Naoyuki Maeda, Kohji Nishida

Erschienen in: Japanese Journal of Ophthalmology | Ausgabe 5/2013

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Abstract

Purpose

To evaluate the preliminary long-term efficacy of diquafosol ophthalmic solution for aqueous-deficient dry eye.

Methods

Fifteen patients with mild-to-moderate aqueous-deficient dry eye were enrolled. After a washout period, the patients were treated with 3 % diquafosol ophthalmic solution for 6 months. We assessed 12 subjective dry eye symptoms, corneal and conjunctival staining with fluorescein, tear film break-up time (BUT), lower tear meniscus height measured with anterior-segment optical coherence tomography, Schirmer’s testing, and adverse reactions at baseline and 1, 3, and 6 months after the start of treatment.

Results

Treatment with diquafosol ophthalmic solution significantly improved dry eye symptoms, corneal staining, BUT, and tear meniscus height at 1 month and maintained the effectiveness for 6 months. Conjunctival staining significantly improved 3 and 6 months after treatment. No significant adverse reactions developed.

Conclusions

Prolonged use of diquafosol ophthalmic solution for 6 months produced significant improvement both subjectively (dry eye symptom score) and objectively (ocular staining score and tear function tests) for aqueous-deficient dry eye.

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Titel: Long-term results of treatment with diquafosol ophthalmic solution for aqueous-deficient dry eye
verfasst von: Shizuka Koh
Chikako Ikeda
Yoshihiro Takai
Hitoshi Watanabe
Naoyuki Maeda
Kohji Nishida
Publikationsdatum: 01.09.2013
Verlag: Springer Japan
Erschienen in: Japanese Journal of Ophthalmology / Ausgabe 5/2013
Print ISSN: 0021-5155
Elektronische ISSN: 1613-2246
DOI: https://doi.org/10.1007/s10384-013-0251-y

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Long-term results of treatment with diquafosol ophthalmic solution for aqueous-deficient dry eye

Abstract

Purpose

Methods

Results

Conclusions

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Springer Medizin

Abstract

Purpose

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Results

Conclusions

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