Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Japanese Journal of Ophthalmology
Erschienen in: Japanese Journal of Ophthalmology 4/2017

26.05.2017 | Clinical Investigation

Impact of intraocular pressure reduction on visual field progression in normal-tension glaucoma followed up over 15 years

verfasst von: Shinya Oie, Kyoko Ishida, Tetsuya Yamamoto

Erschienen in: Japanese Journal of Ophthalmology | Ausgabe 4/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To investigate the impact of surgical or medical reduction of intraocular pressure (IOP) on progressive normal-tension glaucoma followed up over 15 years.

Methods

Sixty eyes of 60 patients were divided into 3 intervention groups: group 1 (trabeculectomy, n = 17); group 2 (IOP reduction rate ≥15% with prostaglandin analogs, n = 24); and group 3 (IOP reduction rate <15% with prostaglandin analogs, n = 19). The preintervention and postintervention mean deviation (MD) slopes and IOP were compared. Factors associated with the rate of visual field progression were identified by multiple regression analysis.

Results

The mean follow-up was 19.8 years. In group 1, the preintervention and postintervention IOPs were 14.7 ± 1.3 and 9.1 ± 2.0 mmHg, respectively (P < .001, 38% reduction). The MD slope decreased significantly after trabeculectomy (−0.86 ± 0.51 versus −0.19 ± 0.20 dB/y; P < .001). In group 2, the preintervention and postintervention IOPs were 14.7 ± 1.5 and 11.7 ± 1.2 mmHg, respectively (P < 0.001, 20% reduction), with significant differences in the MD slope (−0.52 ± 0.37 versus −0.31 ± 0.30 dB/y; P = .019). In group 3, the preintervention and postintervention IOPs were 14.4 ± 1.8 and 13.2 ± 1.6 mmHg, respectively (P < 0.001, 8% reduction), with no differences in the MD slope (−0.40 ± 0.27 versus −0.50 ± 0.65 dB/y; P > .05). Multiple regression analysis showed that the average IOP, IOP reduction rate, and preintervention MD slope were related to the extent of the postintervention reduction in the MD slope. The difference in the preintervention and postintervention MD slopes significantly correlated with the rate of IOP reduction (r = 0.559, P < .001).

Conclusions

A pressure-dependent maintenance effect of the visual field was confirmed in progressive normal-tension glaucoma.
Literatur
1.
Collaborative Normal-Tension Glaucoma Study Group. The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Am J Ophthalmol. 1998;126:498–505.CrossRef
2.
Drance S, Anderson DR, Schulzer M, Collaborative Normal-Tension Glaucoma Study Group. Risk factors for progression of visual field abnormalities in normal-tension glaucoma. Am J Ophthalmol. 2001;131:699–708.CrossRefPubMed
3.
Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M, et al. Reduction of intraocular pressure and glaucoma progression: results from the early manifest glaucoma trial. Arch Ophthalmol. 2002;120:1268–79.CrossRefPubMed
4.
Leske MC, Heijl A, Hussein M, Bengtsson B, Hyman L, Komaroff E, et al. Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial. Arch Ophthalmol. 2003;121:48–56.CrossRefPubMed
5.
Leske MC, Heijl A, Hyman L, Bengtsson B, Dong L, Yang Z, et al. Predictors of long-term progression in the early manifest glaucoma trial. Ophthalmology. 2007;114:1965–72.CrossRefPubMed
6.
Kim M, Kim DM, Park KH, Kim TW, Jeoung JW, Kim SH. Intraocular pressure reduction with topical medications and progression of normal-tension glaucoma: a 12-year mean follow-up study. Acta Ophthalmol. 2013;91:270–5.CrossRef
7.
Aoyama A, Ishida K, Sawada A, Yamamoto T. Target intraocular pressure for stability of visual field loss progression in normal-tension glaucoma. Jpn J Ophthalmol. 2010;54:117–23.CrossRefPubMed
8.
Heijl A, Bengtsson B, Hyman L, Leske MC, Early Manifest Glaucoma Trial G. Natural history of open-angle glaucoma. Ophthalmology. 2009;116:2271–6.CrossRefPubMed
9.
De Moraes CG, Liebmann JM, Greenfield DS, Gardiner SK, Ritch R, Krupin T, et al. Risk factors for visual field progression in the low-pressure glaucoma treatment study. Am J Ophthalmol. 2012;154:702–11.CrossRefPubMed
10.
Membrey WL, Poinoosawmy DP, Bunce C, Fitzke FW, Hitchings RA. Comparison of visual field progression in patients with normal pressure glaucoma between eyes with and without visual field loss that threatens fixation. Br J Ophthalmol. 2000;84:1154–8.CrossRefPubMedPubMedCentral
11.
Fukuchi T, Yoshino T, Sawada H, Seki M, Togano T, Tanaka T, et al. The relationship between the mean deviation slope and follow-up intraocular pressure in open-angle glaucoma patients. J Glaucoma. 2013;22:689–97.CrossRefPubMed
12.
Spry PG, Johnson CA. Identification of progressive glaucomatous visual field loss. Surv Ophthalmology. 2002;47:158–73.CrossRef
13.
Anderson DR, Drance SM, Schulzer M, Collaborative Normal-Tension Glaucoma Study G. Natural history of normal-tension glaucoma. Ophthalmology. 2001;108:247–53.CrossRefPubMed
14.
Sakata R, Aihara M, Murata H, Mayama C, Tomidokoro A, Iwase A, et al. Contributing factors for progression of visual field loss in normal-tension glaucoma patients with medical treatment. J Glaucoma. 2013;22:250–4.CrossRefPubMed
15.
Ahrlich KG, De Moraes CG, Teng CC, Prata TS, Tello C, Ritch R, et al. Visual field progression differences between normal-tension and exfoliative high-tension glaucoma. IOVS. 2010;51:1458–63.
16.
Tomita G, Araie M, Kitazawa Y, Tsukahara S. A three-year prospective, randomized and open comparison between latanoprost and timolol in Japanese normal-tension glaucoma patients. Eye. 2004;18:984–9.CrossRefPubMed
17.
Araie M, Shirato S, Yamazaki Y, Kitazawa Y, Ohashi Y, Nipradilol-Timolol Study G. Visual field loss in patients with normal-tension glaucoma under topical nipradilol or timolol: subgroup and subfield analyses of the nipradilol-timolol study. Jpn J Ophthalmol. 2010;54:278–85.CrossRefPubMed
18.
Heijl A, Buchholz P, Norrgren G, Bengtsson B. Rates of visual field progression in clinical glaucoma care. Acta Ophthalmol. 2013;91:406–12.CrossRefPubMed
19.
European Glaucoma Society. Terminology and guidelines for glaucoma. 4th ed. Savona: European Glaucoma Society Fundation; 2014.
20.
Choi YJ, Kim M, Park KH, Kim DM, Kim SH. The risk of newly developed visual impairment in treated normal-tension glaucoma: 10-year follow-up. Acta Ophthalmol. 2014;92:644–9.CrossRef
21.
Lee J, Sohn SW, Kee C. Effect of Ginkgo biloba extract on visual field progression in normal tension glaucoma. J Glaucoma. 2013;22:780–4.CrossRefPubMed
22.
Komori S, Ishida K, Yamamoto T. Results of long-term monitoring of normal-tension glaucoma patients receiving medical therapy: results of an 18-year follow-up. Graefes Arch Clin Exp Ophthalmol. 2014;252:1963–70.CrossRefPubMed
23.
Cheng JW, Cai JP, Wei RL. Meta-analysis of medical intervention for normal tension glaucoma. Ophthalmology. 2009;116:1243–9.CrossRefPubMed
24.
Anderson DR, Patella VM. Interpretation of a single field. Automated static perimetry. St. Louis: Mosby; 1999. p. 121–90.
25.
Nakazawa T, Shimura M, Ryu M, Himori N, Nitta F, Omodaka K, et al. Progression of visual field defects in eyes with different optic disc appearances in patients with normal tension glaucoma. J Glaucoma. 2012;21:426–30.CrossRefPubMed
26.
Fukuchi T, Yoshino T, Sawada H, Seki M, Togano T, Tanaka T, et al. Progression rate of total, and upper and lower visual field defects in open-angle glaucoma patients. Clin Ophthalmol. 2010;4:1315–23.CrossRefPubMedPubMedCentral
27.
Shigeeda T, Tomidokoro A, Araie M, Koseki N, Yamamoto S. Long-term follow-up of visual field progression after trabeculectomy in progressive normal-tension glaucoma. Ophthalmology. 2002;109:766–70.CrossRefPubMed
28.
Chauhan BC, Malik R, Shuba LM, Rafuse PE, Nicolela MT, Artes PH. Rates of glaucomatous visual field change in a large clinical population. IOVS. 2014;55:4135–43.
29.
Chauhan BC, Garway-Heath DF, Goni FJ, Rossetti L, Bengtsson B, Viswanathan AC, et al. Practical recommendations for measuring rates of visual field change in glaucoma. Br J Ophthalmol. 2008;92:569–73.CrossRefPubMedPubMedCentral
30.
Krupin T, Liebmann JM, Greenfield DS, Ritch R, Gardiner S, Low-Pressure Glaucoma Study G. A randomized trial of brimonidine versus timolol in preserving visual function: results from the Low-Pressure Glaucoma Treatment Study. Am J Ophthalmol. 2011;151:671–81.CrossRefPubMed
31.
The AGIS Investigators. Advanced Glaucoma Intervention Study: 2. Visual field test scoring and reliability. Ophthalmology. 1994;101:1445–55.CrossRef
32.
The AGIS Investigators. The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. Am J Ophthalmol. 2000;130:429–40.CrossRef
33.
The AGIS Investigators. The Advanced Glaucoma Intervention Study (AGIS): 12. Baseline risk factors for sustained loss of visual field and visual acuity in patients with advanced glaucoma. Am J Ophthalmol. 2002;134:499–512.CrossRef
34.
Ederer F, Gaasterland DA, Dally LG, Kim J, VanVeldhuisen PC, Blackwell B, et al. The Advanced Glaucoma Intervention Study (AGIS): 13. Comparison of treatment outcomes within race: 10-year results. Ophthalmology. 2004;111:651–64.CrossRefPubMed
35.
Caprioli J, Coleman AL. Intraocular pressure fluctuation a risk factor for visual field progression at low intraocular pressures in the advanced glaucoma intervention study. Ophthalmology. 2008;115:1123–9.CrossRefPubMed
36.
Gillespie BW, Musch DC, Guire KE, Mills RP, Lichter PR, Janz NK, et al. The collaborative initial glaucoma treatment study: baseline visual field and test-retest variability. IOVS. 2003;44:2613–20.
37.
Musch DC, Gillespie BW, Lichter PR, Niziol LM, Janz NK, Investigators CS. Visual field progression in the Collaborative Initial Glaucoma Treatment Study: the impact of treatment and other baseline factors. Ophthalmology. 2009;116:200–7.CrossRefPubMed
38.
Musch DC, Gillespie BW, Niziol LM, Lichter PR, Varma R, Group CS. Intraocular pressure control and long-term visual field loss in the Collaborative Initial Glaucoma Treatment Study. Ophthalmology. 2011;118:1766–73.CrossRefPubMedPubMedCentral
39.
Nakagami T, Yamazaki Y, Hayamizu F. Prognostic factors for progression of visual field damage in patients with normal-tension glaucoma. Jpn J Ophthalmol. 2006;50:38–43.CrossRefPubMed
40.
Folgar FA, de Moraes CG, Prata TS, Teng CC, Tello C, Ritch R, et al. Glaucoma surgery decreases the rates of localized and global visual field progression. Am J Ophthalmol. 2010;149:258–64.CrossRefPubMed
41.
Higashide T, Ohkubo S, Sugimoto Y, Kiuchi Y, Sugiyama K. Persistent hypotony after trabeculectomy: incidence and associated factors in the Collaborative Bleb-Related Infection Incidence and Treatment Study. Jpn J Ophthalmol. 2016;60:309–18.CrossRefPubMed
42.
Ma KT, Kim CY, Seong GJ, Lee SH, Park JW, Ha SJ, et al. Intraocular pressure reduction in normal-tension glaucoma patients in South Korea. Int Ophthalmol. 2011;31:355–61.CrossRefPubMed
43.
Lee J, Kong M, Kim J, Kee C. Comparison of visual field progression between relatively low and high intraocular pressure groups in normal tension glaucoma patients. J Glaucoma. 2014;23:553–60.CrossRefPubMed
44.
Bhardwaj N, Niles PI, Greenfield DS, Hymowitz M, Sehi M, Feuer WJ, et al. The impact of surgical intraocular pressure reduction on visual function using various criteria to define visual field progression. J Glaucoma. 2013;22:632–7.CrossRefPubMedPubMedCentral
Metadaten
Titel
Impact of intraocular pressure reduction on visual field progression in normal-tension glaucoma followed up over 15 years
verfasst von
Shinya Oie
Kyoko Ishida
Tetsuya Yamamoto
Publikationsdatum
26.05.2017
Verlag
Springer Japan
Erschienen in
Japanese Journal of Ophthalmology / Ausgabe 4/2017
Print ISSN: 0021-5155
Elektronische ISSN: 1613-2246
DOI
https://doi.org/10.1007/s10384-017-0519-8

Weitere Artikel der Ausgabe 4/2017

Japanese Journal of Ophthalmology 4/2017 Zur Ausgabe

Clinical Investigation

Immunophenotypic profiles for distinguishing orbital mucosa-associated lymphoid tissue lymphoma from benign lymphoproliferative tumors

Clinical Investigation

The relationship between vascular endothelial dysfunction and treatment frequency in neovascular age-related macular degeneration

Clinical Investigation

Patterns of glaucoma progression in retinal nerve fiber and macular ganglion cell-inner plexiform layer in spectral-domain optical coherence tomography

Clinical Investigation

Upper fornix approach combined with a superior lateral cantholysis: a minimally invasive approach to the superonasal intraconal space

Clinical Investigation

Development of visual field defect after first-detected optic disc hemorrhage in preperimetric open-angle glaucoma

Clinical Investigation

Effect of glaucoma implant surgery on intraocular pressure reduction, flare count, anterior chamber depth, and corneal endothelium in primary open-angle glaucoma

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Therapieverfahren in der Augenheilkunde CME-Artikel

Die Verwendung von Ophthalmika in der Schwangerschaft und Stillzeit stellt immer eine Off-label-Anwendung dar. Ein Einsatz von Arzneimitteln muss daher besonders sorgfältig auf sein Risiko-Nutzen-Verhältnis bewertet werden. In der vorliegenden …

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Vitrektomie Originalie

Die endogene Endophthalmitis ist eine hämatogen fortgeleitete, bakterielle oder fungale Infektion, die über choroidale oder retinale Gefäße in den Augapfel eingeschwemmt wird [ 1 – 3 ]. Von dort infiltrieren die Keime in die Netzhaut, den …

Bakterielle endogene Endophthalmitis

Vitrektomie Leitthema

Eine endogene Endophthalmitis stellt einen ophthalmologischen Notfall dar, der umgehender Diagnostik und Therapie bedarf. Es sollte mit geeigneten Methoden, wie beispielsweise dem Freiburger Endophthalmitis-Set, ein Keimnachweis erfolgen. Bei der …

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Erkrankungen der Hornhaut CME-Artikel

Die bestmögliche Wundheilung der Kornea, insbesondere ohne die Ausbildung von lichtstreuenden Narben, ist oberstes Gebot, um einer dauerhaften Schädigung der Hornhaut frühzeitig entgegenzuwirken und die Funktion des Auges zu erhalten.   

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise