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Journal of Public Health

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28.07.2017 | Original Article

Systematic review and meta-analysis: dairy consumption and hepatocellular carcinoma risk

verfasst von: Yunyun Yang, Ju Zhou, Ying Yang, Zhi Chen, Xiaodong Zheng

Erschienen in: Journal of Public Health | Ausgabe 6/2017

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Abstract

Aim

This study conducts a systematic review and meta-analysis to assess the association between dairy consumption and hepatocellular carcinoma (HCC) risk.

Subjects and methods

The association between consumption of overall dairy, specific dairy products (such as milk, cheese, butter, yoghurt, condensed milk, whey, casein, lactose) and HCC risk has not been assessed before. This association between dairy consumption and HCC risk has been reported in several epidemiological studies, but results were controversial and inconsistent. The PubMed, EMBASE and Cochrane databases were searched for relevant studies published up to September 20, 2015. The relative risks (RRs) and odds ratios (ORs) with 95% confidence intervals (CIs) for dairy consumption associated with HCC risk were extracted from each included cohort as well as case-control study. In our study, the pooled RR was obtained using the random-effects model. Heterogeneity was evaluated by Q and I ² statistics.

Results

A total number of 1,084,666 participants and 2041 HCC patients from three cohort studies and five case-control studies were included in this meta-analysis. The pooled RR of dairy was 1.38 (95% CI: 1.00–1.91, p = 0.00) in all studies. The pooled RR of milk, yoghurt, and cheese was 1.13 (95% CI: 0.67–1.88, p = 0.00), 0.40 (95% CI: 0.14–1.14, p = 0.00) and 1.45 (95% CI: 1.02–2.07, p = 0.80), respectively.

Conclusions

This meta-analysis indicates that consumption of overall dairy may be associated with increased HCC risk and a risk factor involved in the etiology of HCC.

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Abid Z, Cross AJ, Sinha R (2014) Meat, dairy, and cancer. Am J Clin Nutr 100:386S–393SCrossRefPubMedPubMedCentral

Alzahrani B, Iseli TJ, Hebbard LW (2014) Non-viral causes of liver cancer. Does obesity led inflammation play a role? Cancer Lett 345:223–229CrossRefPubMed

Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088–1101CrossRefPubMed

Burden ST, Stamataki Z, Hill J, Molasiotis A, Todd C (2015) An exploration of food and the lived experience of individuals after treatment for colorectal cancer using a phenomenological approach. J Hum Nutr Diet 29:137–145CrossRefPubMed

Chen Y, Wang X, Wang J, Yan Z, Luo J (2012) Excess body weight and the risk of primary liver cancer, an updated meta-analysis of prospective studies. Eur J Cancer 48:2137–2145CrossRefPubMed

DeBac C, Stroffolini T, Gaeta GB, Taliani G, Giusti G (1994) Pathogenic factors in cirrhosis with and without hepatocellular carcinoma: a multicenter Italian study. Hepatology 20:1225–1230CrossRef

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188CrossRefPubMed

Dietrich P, Hellerbrand C (2014) Non-alcoholic fatty liver disease, obesity and the metabolic syndrome. Best Pract Res Clin Gastroenterol 28:637–653CrossRefPubMed

Duarte-Salles T, Fedirko V, Stepien M, Trichopoulou A, Bamia C, Lagiou P, Lukanova A, Trepo E, Overvad K, Tjønneland A, Halkjaer J, Boutron-Ruault MC, Racine A, Cadeau C, Kühn T, Aleksandrova K, Trichopoulos D, Tsiotas K, Boffetta P, Palli D, Pala V, Tumino R, Sacerdote C, Panico S, Bueno-de-Mesquita HB, Dik VK, Peeters PH, Weiderpass E, Torhild Gram I, Hjartåker A, Ramón Quirós J, Fonseca-Nunes A, Molina-Montes E, Dorronsoro M, Navarro Sanchez C, Barricarte A, Lindkvist B, Sonestedt E, Johansson I, Wennberg M, Khaw KT, Wareham N, Travis RC, Romieu I, Riboli E, Jenab M (2014) Dairy products and risk of hepatocellular carcinoma: the European prospective investigation into cancer and nutrition. Int J Cancer 135:1662–1672CrossRefPubMed

Duval S, Tweedie R (2000) Trim and fill, a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56:455–463CrossRefPubMed

Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634CrossRefPubMedPubMedCentral

Fukuda K, Shibata A, Hirohata I, Tanikawa K, Yamaguchi G, Ishii M (1993) A hospital-based case-control study on hepatocellular carcinoma in Fukuoka and Saga prefectures, northern Kyushu, Japan. Jpn J Cancer Res 84:708–714CrossRefPubMed

Gomaa AI, Khan SA, Toledano MB, Waked I, Taylor-Robinson SD (2008) Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis. World J Gastroenterol 21: 4300-4308

Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, Calderaro J, Bioulac-Sage P, Letexier M, Degos F, Clément B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouzé E, Calvo F, Zucman-Rossi J (2012) Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat Genet 44:694–698CrossRefPubMedPubMedCentral

Han ZG (2012) Functional genomic studies: insights into the pathogenesis of liver cancer. Annu Rev Genomics Hum Genet 13:171–205CrossRefPubMed

Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557CrossRefPubMedPubMedCentral

Isenring E, Capra S, Bauer J (2011) Nutrition support, quality of life and clinical outcomes. J Hum Nutr Diet 25:507–508

Kanazir M, Boricic I, Delic D, Tepavcevic DK, Knezevic A, Jovanovic T, Pekmezovic T (2010) Risk factors for hepatocellular carcinoma: a case-control study in Belgrade (Serbia). Tumori 96:911–917PubMed

Kulkarni K, Barcak E, El-Serag H, Goodgame R (2004) The impact of immigration on the increasing incidence of hepatocellular carcinoma in the United States. Aliment Pharmacol Ther 20:445–450CrossRefPubMed

Kuper H, Tzonou A, Lagiou P, Mucci LA, Trichopoulos D, Stuver SO, Trichopoulou A (2000) Diet and hepatocellular carcinoma: a case-control study in Greece. Nutr Cancer 38:6–12CrossRefPubMed

Kurozawa Y, Ogimoto I, Shibata A, Nose T, Yoshimura T, Suzuki H, Fujita Y, Ichikawa S, Iwai N, Fukuda K, Tamakoshi A (2004) Dietary habits and risk of death due to hepatocellular carcinoma in a large scale cohort study in Japan. Kurume Med J 51:141–149CrossRefPubMed

La Vecchia C, Negri E, Decarli A, D’Avanzo B, Franceschi S (1988) Risk factors for hepatocellular carcinoma in northern Italy. Int J Cancer 42:872–876CrossRefPubMed

Li WQ, Park Y, Park Y, Hollenbeck AR, Taylor PR, Goldstein AM, Freedman ND (2014) Index-based dietary patterns and risk of incident hepatocellular carcinoma and mortality from chronic liver disease in a prospective study. Hepatology 60:589–597

Mandair DS, Rossi RE, Pericleous M, Whyand T, Caplin M (2014) The impact of diet and nutrition in the prevention and progression of hepatocellular carcinoma. Expert Rev Gastroenterol Hepatol 8:369–382CrossRefPubMed

Mayne ST, Playdon MC, Rock CL (2016) Diet, nutrition, and cancer: past, present and future. Nat Rev Clin Oncol 13:504–515CrossRefPubMed

Missmer SA, Smith-Warner SA, Spiegelman D, Yaun S-S, Adami H-O, Beeson WL, van den Brandt PA, Fraser GE, Freudenheim JL, Goldbohm RA, Graham S, Kushi LH, Miller AB, Potter JD, Rohan TE, Speizer FE, Toniolo P, Willett WC, Wolk A, Zeleniuch-Jacquotte A, Hunter DJ (2002) Meat and dairy food consumption and breast cancer: a pooled analysis of cohort studies. Int J Epidemiol 31:78–85CrossRefPubMed

Nishida N, Kudo M (2013) Recent advancements in comprehensive genetic analyses for human hepatocellular carcinoma. Oncology 84:93–97CrossRefPubMed

Norat T, Riboli E (2003) Dairy products and colorectal cancer: a review of possible mechanisms and epidemiological evidence. Eur J Clin Nutr 57:1–17CrossRefPubMed

Park Y, Leitzmann MF, Subar AF, Hollenbeck A, Schatzkin A (2009) Dairy food, calcium, and risk of cancer in the NIH-AARP diet and health study. Arch Intern Med 169:391–401CrossRefPubMedPubMedCentral

Rajagopal NA, Erik NK, Cressman CJ (2013) Steer cellular and molecular mechanisms of hepatocellular carcinoma: an update. Arch Toxicol 87:227–247CrossRef

Renehan AG, Zwahlen M, Minder C, O’Dwyer ST, Shalet SM, Egger M (2004) Insulin-like growth factor, IGF-I, IGF binding protein-3, and cancer risk, systematic review and meta-regression analysis. Lancet 363:1346–1353CrossRefPubMed

Ruiz RB, Hernández PS (2014) Diet and cancer: risk factors and epidemiological evidence. Maturitas 77:202–208CrossRef

Shou Q, Chen F, Cai Y, Zhang S, Tu J, Zhang L, Wang D, Wang J, Chen M, Fu H (2015) Inhibition of diethylnitrosamine-induced hepatocarcinogenesis in mice by a high dietary protein intake. Nutr Cancer 11:1–8

Siegel R, Ma J, Zou Z, Jemal A (2014) Cancer statistics. CA Cancer J Clin 64:9–29CrossRefPubMed

Singh S, Singh PP, Roberts LR, Sanchez W (2014) Chemopreventive strategies in hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol 11:45–54CrossRefPubMed

Talamini R, Polesel J, Montella M, Maso LD, Crispo A, Tommasi LG, Izzo F, Crovatto M, La Vecchia C, Franceschi S (2006) Food groups and risk of hepatocellular carcinoma: a multicenter case-control study in Italy. Int J Cancer 119:2916–2921CrossRefPubMed

Venook AP, Papandreou C, Furuse J, Guevara LL (2010) The Incidence and Epidemiology of Hepatocellular Carcinoma: A Global and Regional Perspective. Oncologist 15: 5–13

Wang P, Kang D, Cao W, Wang Y, Liu Z (2012) Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta-analysis. Diabetes Metab Res Rev 28:109–122CrossRefPubMed

Yu SZ, Huang XE, Koide T, Cheng G, Chen GC, Harada K, Ueno Y, Sueoka E, Oda H, Tashiro F, Mizokami M, Ohno T, Xiang J, Tokudome S (2002) Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China. Jpn J Cancer Res 93:1287–1292

Titel: Systematic review and meta-analysis: dairy consumption and hepatocellular carcinoma risk
verfasst von: Yunyun Yang
Ju Zhou
Ying Yang
Zhi Chen
Xiaodong Zheng
Publikationsdatum: 28.07.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Public Health / Ausgabe 6/2017
Print ISSN: 2198-1833
Elektronische ISSN: 1613-2238
DOI: https://doi.org/10.1007/s10389-017-0806-3

Springer Medizin

Abstract

Aim

Subjects and methods

Results

Conclusions

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