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01.10.2013 | Original Paper

Prostate specific membrane antigen produces pro-angiogenic laminin peptides downstream of matrix metalloprotease-2

verfasst von: Rebecca E. Conway, Kyle Joiner, Alex Patterson, David Bourgeois, Robert Rampp, Benjamin C. Hannah, Samantha McReynolds, John M. Elder, Hannah Gilfilen, Linda H. Shapiro

Erschienen in: Angiogenesis | Ausgabe 4/2013

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Abstract

Prostate specific membrane antigen (PSMA) is a pro-angiogenic cell-surface protease that we previously demonstrated regulates blood vessel formation in a laminin and integrin β₁-dependent manner. Here, we examine the principal mechanism of PSMA activation of integrin β₁. We show that digesting laminin sequentially with recombinant matrix metalloprotease-2 (MMP-2) and PSMA generates small peptides that enhance endothelial cell adhesion and migration in vitro. We also provide evidence that these laminin peptides activate adhesion via integrin α₆β₁ and focal adhesion kinase. Using an in vivo Matrigel implant assay, we show that these MMP/PSMA-derived laminin peptides also increase angiogenesis in vivo. Together, our results reveal a novel mechanism of PSMA activation of angiogenesis by processing laminin downstream of MMP-2.

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Titel: Prostate specific membrane antigen produces pro-angiogenic laminin peptides downstream of matrix metalloprotease-2
verfasst von: Rebecca E. Conway
Kyle Joiner
Alex Patterson
David Bourgeois
Robert Rampp
Benjamin C. Hannah
Samantha McReynolds
John M. Elder
Hannah Gilfilen
Linda H. Shapiro
Publikationsdatum: 01.10.2013
Verlag: Springer Netherlands
Erschienen in: Angiogenesis / Ausgabe 4/2013
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-013-9360-y

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