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Erschienen in: AIDS and Behavior 5/2011

01.07.2011 | Original Paper

Scaling Up Circumcision Programs in Southern Africa: The Potential Impact of Gender Disparities and Changes in Condom Use Behaviors on Heterosexual HIV Transmission

verfasst von: Kyeen M. Andersson, Douglas K. Owens, A. David Paltiel

Erschienen in: AIDS and Behavior | Ausgabe 5/2011

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Abstract

Circumcision significantly reduces female-to-male transmission of HIV infection, but changes in behavior may influence the overall impact on transmission. We sought to explore these effects, particularly for societies where women have less power to negotiate safe sex. We developed a compartmental epidemic model to simulate the population-level impact of various circumcision programs on heterosexual HIV transmission in Soweto. We incorporated gender-specific negotiation of condom use in sexual partnerships and explored post-circumcision changes in condom use. A 5-year prevention program in which only an additional 10% of uncircumcised males undergo circumcision each year, for example, would prevent 13% of the expected new HIV infections over 20 years. Outcomes were sensitive to potential changes in behavior and differed by gender. For Southern Africa, even modest programs offering circumcision would result in significant benefits. Because decreases in male condom use could diminish these benefits, particularly for women, circumcision programs should emphasize risk-reduction counseling.
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Literatur
1.
Zurück zum Zitat Gray RH, Kigozi G, Serwadda D, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet. 2007;369(9562):657–66.PubMedCrossRef Gray RH, Kigozi G, Serwadda D, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet. 2007;369(9562):657–66.PubMedCrossRef
2.
Zurück zum Zitat Bailey RC, Moses S, Parker CB, et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. Lancet. 2007;369(9562):643–56.PubMedCrossRef Bailey RC, Moses S, Parker CB, et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. Lancet. 2007;369(9562):643–56.PubMedCrossRef
3.
Zurück zum Zitat Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med. 2005;2(11):1112–22.CrossRef Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med. 2005;2(11):1112–22.CrossRef
4.
Zurück zum Zitat Westercamp N, Bailey RC. Acceptability of male circumcision for prevention of HIV/AIDS in sub-Saharan Africa: a review. AIDS Behav. 2007;11(3):341–55.PubMedCrossRef Westercamp N, Bailey RC. Acceptability of male circumcision for prevention of HIV/AIDS in sub-Saharan Africa: a review. AIDS Behav. 2007;11(3):341–55.PubMedCrossRef
5.
Zurück zum Zitat Cassell MM, Halperin DT, Shelton JD, Stanton D. Risk compensation: the Achilles’ heel of innovations in HIV prevention? BMJ. 2006;332(7541):605–7.PubMedCrossRef Cassell MM, Halperin DT, Shelton JD, Stanton D. Risk compensation: the Achilles’ heel of innovations in HIV prevention? BMJ. 2006;332(7541):605–7.PubMedCrossRef
6.
Zurück zum Zitat Mattson CL, Campbell RT, Bailey RC, et al. Risk compensation is not associated with male circumcision in Kisumu, Kenya: a multi-faceted assessment of men enrolled in a randomized controlled trial. PLoS ONE. 2008;3(6):e2443.PubMedCrossRef Mattson CL, Campbell RT, Bailey RC, et al. Risk compensation is not associated with male circumcision in Kisumu, Kenya: a multi-faceted assessment of men enrolled in a randomized controlled trial. PLoS ONE. 2008;3(6):e2443.PubMedCrossRef
7.
Zurück zum Zitat Wegbreit J, Bertozzi S, DeMaria LM, Padian NS. Effectiveness of HIV prevention strategies in resource-poor countries: tailoring the intervention to the context. AIDS. 2006;20(9):1217–35.PubMedCrossRef Wegbreit J, Bertozzi S, DeMaria LM, Padian NS. Effectiveness of HIV prevention strategies in resource-poor countries: tailoring the intervention to the context. AIDS. 2006;20(9):1217–35.PubMedCrossRef
8.
Zurück zum Zitat Wawer MJ, Makumbi F, Kigozi G, et al. Circumcision in HIV-infected men and its effect on HIV transmission to female partners in Rakai, Uganda: a randomised controlled trial. Lancet. 2009;374(9685):229–37.PubMedCrossRef Wawer MJ, Makumbi F, Kigozi G, et al. Circumcision in HIV-infected men and its effect on HIV transmission to female partners in Rakai, Uganda: a randomised controlled trial. Lancet. 2009;374(9685):229–37.PubMedCrossRef
9.
Zurück zum Zitat Agot KE, Kiarie JN, Nguyen HQ, Odhiambo JO, Onyango TM, Weiss NS. Male circumcision in Siaya and Bondo Districts, Kenya: prospective cohort study to assess behavioral disinhibition following circumcision. J Acquir Immune Defic Syndr. 2007;44(1):66–70.PubMedCrossRef Agot KE, Kiarie JN, Nguyen HQ, Odhiambo JO, Onyango TM, Weiss NS. Male circumcision in Siaya and Bondo Districts, Kenya: prospective cohort study to assess behavioral disinhibition following circumcision. J Acquir Immune Defic Syndr. 2007;44(1):66–70.PubMedCrossRef
10.
Zurück zum Zitat Weiss HA, Halperin D, Bailey RC, Hayes RJ, Schmid G, Hankins CA. Male circumcision for HIV prevention: from evidence to action? AIDS. 2008;22(5):567–74.PubMedCrossRef Weiss HA, Halperin D, Bailey RC, Hayes RJ, Schmid G, Hankins CA. Male circumcision for HIV prevention: from evidence to action? AIDS. 2008;22(5):567–74.PubMedCrossRef
11.
Zurück zum Zitat Eaton L, Kalichman SC. Behavioral aspects of male circumcision for the prevention of HIV infection. Curr HIV/AIDS Rep. 2009;6(4):187–93.PubMedCrossRef Eaton L, Kalichman SC. Behavioral aspects of male circumcision for the prevention of HIV infection. Curr HIV/AIDS Rep. 2009;6(4):187–93.PubMedCrossRef
12.
Zurück zum Zitat Berer M. Male circumcision for HIV prevention: what about protecting men’s partners? Reprod Health Matters. 2008;16(32):171–5.PubMedCrossRef Berer M. Male circumcision for HIV prevention: what about protecting men’s partners? Reprod Health Matters. 2008;16(32):171–5.PubMedCrossRef
13.
14.
Zurück zum Zitat Hankins C. Male circumcision: implications for women as sexual partners and parents. Reprod Health Matters. 2007;15(29):62–7.PubMedCrossRef Hankins C. Male circumcision: implications for women as sexual partners and parents. Reprod Health Matters. 2007;15(29):62–7.PubMedCrossRef
15.
Zurück zum Zitat Berer M. Male circumcision for HIV prevention: perspectives on gender and sexuality. Reprod Health Matters. 2007;15(29):45–8.PubMedCrossRef Berer M. Male circumcision for HIV prevention: perspectives on gender and sexuality. Reprod Health Matters. 2007;15(29):45–8.PubMedCrossRef
16.
Zurück zum Zitat Gray RH, Li X, Kigozi G, et al. The impact of male circumcision on HIV incidence and cost per infection prevented: a stochastic simulation model from Rakai, Uganda. AIDS. 2007;21(7):845–50.PubMedCrossRef Gray RH, Li X, Kigozi G, et al. The impact of male circumcision on HIV incidence and cost per infection prevented: a stochastic simulation model from Rakai, Uganda. AIDS. 2007;21(7):845–50.PubMedCrossRef
17.
Zurück zum Zitat Williams BG, Lloyd-Smith JO, Gouws E, et al. The potential impact of male circumcision on HIV in sub-Saharan Africa. PLoS Med. 2006;3(7):1032–40. Williams BG, Lloyd-Smith JO, Gouws E, et al. The potential impact of male circumcision on HIV in sub-Saharan Africa. PLoS Med. 2006;3(7):1032–40.
18.
Zurück zum Zitat Nagelkerke NJD, Moses S, de Vlas SJ, Bailey RC. Modelling the public health impact of male circumcision for HIV prevention in high prevalence areas in Africa. BMC Infect Dis. 2007;7:16–30.PubMedCrossRef Nagelkerke NJD, Moses S, de Vlas SJ, Bailey RC. Modelling the public health impact of male circumcision for HIV prevention in high prevalence areas in Africa. BMC Infect Dis. 2007;7:16–30.PubMedCrossRef
19.
Zurück zum Zitat Kahn JG, Marseille E, Auvert B. Cost-effectiveness of male circumcision for HIV prevention in a South African setting. PLoS Med. 2006;3(12):2349–58.CrossRef Kahn JG, Marseille E, Auvert B. Cost-effectiveness of male circumcision for HIV prevention in a South African setting. PLoS Med. 2006;3(12):2349–58.CrossRef
20.
Zurück zum Zitat Podder CN, Sharomi O, Gumel AB, Moses S. To cut or not to cut: a modeling approach for assessing the role of male circumcision in HIV control. Bull Math Biol. 2007;69(8):2447–66.PubMedCrossRef Podder CN, Sharomi O, Gumel AB, Moses S. To cut or not to cut: a modeling approach for assessing the role of male circumcision in HIV control. Bull Math Biol. 2007;69(8):2447–66.PubMedCrossRef
21.
Zurück zum Zitat Hallett TB, Singh K, Smith JA, et al. Understanding the impact of male circumcision interventions on the spread of HIV in southern Africa. PLoS ONE. 2008;3(5):e2212.PubMedCrossRef Hallett TB, Singh K, Smith JA, et al. Understanding the impact of male circumcision interventions on the spread of HIV in southern Africa. PLoS ONE. 2008;3(5):e2212.PubMedCrossRef
22.
Zurück zum Zitat White RG, Glynn JR, Orroth KK, et al. Male circumcision for HIV prevention in sub-Saharan Africa: who, what and when? AIDS. 2008;22(14):1841–50.PubMedCrossRef White RG, Glynn JR, Orroth KK, et al. Male circumcision for HIV prevention in sub-Saharan Africa: who, what and when? AIDS. 2008;22(14):1841–50.PubMedCrossRef
23.
Zurück zum Zitat Bollinger LA, Stover J, Musuka G, et al. The cost and impact of male circumcision on HIV/AIDS in Botswana. J Int AIDS Soc. 2009;12(1):7.PubMedCrossRef Bollinger LA, Stover J, Musuka G, et al. The cost and impact of male circumcision on HIV/AIDS in Botswana. J Int AIDS Soc. 2009;12(1):7.PubMedCrossRef
24.
Zurück zum Zitat Londish GJ, Murray JM. Significant reduction in HIV prevalence according to male circumcision intervention in sub-Saharan Africa. Int J Epid. 2008;37(6):1246–53.CrossRef Londish GJ, Murray JM. Significant reduction in HIV prevalence according to male circumcision intervention in sub-Saharan Africa. Int J Epid. 2008;37(6):1246–53.CrossRef
25.
Zurück zum Zitat UNAIDS/WHO/SACEMA expert group on modelling the impact and cost of male circumcision for HIV prevention. Male circumcision for HIV prevention in high HIV prevalence settings: what can mathematical modelling contribute to informed decision making? PLoS Med. 2009;6(9):e1000109. UNAIDS/WHO/SACEMA expert group on modelling the impact and cost of male circumcision for HIV prevention. Male circumcision for HIV prevention in high HIV prevalence settings: what can mathematical modelling contribute to informed decision making? PLoS Med. 2009;6(9):e1000109.
26.
Zurück zum Zitat Andersson KM, Owens DK, Vardas E, Gray GE, McIntyre JA, Paltiel AD. Predicting the impact of a partially effective HIV vaccine and subsequent risk behavior change on the heterosexual HIV epidemic in low- and middle-income countries: a South African example. J Acquir Immune Defic Syndr. 2007;46(1):78–90.PubMed Andersson KM, Owens DK, Vardas E, Gray GE, McIntyre JA, Paltiel AD. Predicting the impact of a partially effective HIV vaccine and subsequent risk behavior change on the heterosexual HIV epidemic in low- and middle-income countries: a South African example. J Acquir Immune Defic Syndr. 2007;46(1):78–90.PubMed
27.
Zurück zum Zitat Shisana O, Simbayi L. Nelson Mandela/HSRC study of HIV/AIDS: South African National HIV prevalence, behavioural risks and mass media: household survey 2002. Cape Town: Human Sciences Research Council Press; 2002. Shisana O, Simbayi L. Nelson Mandela/HSRC study of HIV/AIDS: South African National HIV prevalence, behavioural risks and mass media: household survey 2002. Cape Town: Human Sciences Research Council Press; 2002.
28.
Zurück zum Zitat Pettifor AE, Rees HV, Kleinschmidt I, et al. Young people’s sexual health in South Africa: HIV prevalence and sexual behaviors from a nationally representative household survey. AIDS. 2005;19(14):1525–34.PubMedCrossRef Pettifor AE, Rees HV, Kleinschmidt I, et al. Young people’s sexual health in South Africa: HIV prevalence and sexual behaviors from a nationally representative household survey. AIDS. 2005;19(14):1525–34.PubMedCrossRef
29.
Zurück zum Zitat Lagarde E, Dirk T, Puren A, Reathe R-T, Auvert B. Acceptability of male circumcision as a tool for preventing HIV infection in a highly infected community in South Africa. AIDS. 2003;17(1):89–95.PubMedCrossRef Lagarde E, Dirk T, Puren A, Reathe R-T, Auvert B. Acceptability of male circumcision as a tool for preventing HIV infection in a highly infected community in South Africa. AIDS. 2003;17(1):89–95.PubMedCrossRef
30.
Zurück zum Zitat Wise J. Demand for male circumcision rises in a bid to prevent HIV. Bull World Health Organ. 2006;84(7):509–11.PubMed Wise J. Demand for male circumcision rises in a bid to prevent HIV. Bull World Health Organ. 2006;84(7):509–11.PubMed
31.
Zurück zum Zitat Simbayi L, Strebel A, Wilson T et al. (1999) Sexually transmitted diseases in the south african public sector. Cape Town: National department of health’s directorate of health systems research and epidemiology in conjunction with the directorate of HIV/AIDS and STDs; August. Simbayi L, Strebel A, Wilson T et al. (1999) Sexually transmitted diseases in the south african public sector. Cape Town: National department of health’s directorate of health systems research and epidemiology in conjunction with the directorate of HIV/AIDS and STDs; August.
32.
Zurück zum Zitat Pettifor AE, Measham DM, Rees HV, Padian NS. Sexual power and HIV risk, South Africa. Emerg Infect Dis. 2004;10(11):1996–2004.PubMed Pettifor AE, Measham DM, Rees HV, Padian NS. Sexual power and HIV risk, South Africa. Emerg Infect Dis. 2004;10(11):1996–2004.PubMed
33.
Zurück zum Zitat Ackermann L, de Klerk GW. Social factors that make South African women vulnerable to HIV infection. Health Care Women Int. 2002;23(2):163–72.PubMedCrossRef Ackermann L, de Klerk GW. Social factors that make South African women vulnerable to HIV infection. Health Care Women Int. 2002;23(2):163–72.PubMedCrossRef
34.
Zurück zum Zitat Dunkle KL, Jewkes RK, Brown HC, et al. Gender-based violence, relationship power, and risk of HIV infection in women attending antenatal clinics in South Africa. Lancet. 2004;363(9419):1415–21.PubMedCrossRef Dunkle KL, Jewkes RK, Brown HC, et al. Gender-based violence, relationship power, and risk of HIV infection in women attending antenatal clinics in South Africa. Lancet. 2004;363(9419):1415–21.PubMedCrossRef
35.
Zurück zum Zitat The World Health Organization (WHO), the joint United nations programme on HIV/AIDS (UNAIDS), and the United nations children’s fund (UNICEF). Toward universal access: scaling up priority HIV/AIDS interventions in the health sector: Progress Report 2008. Geneva: WHO. 2008. The World Health Organization (WHO), the joint United nations programme on HIV/AIDS (UNAIDS), and the United nations children’s fund (UNICEF). Toward universal access: scaling up priority HIV/AIDS interventions in the health sector: Progress Report 2008. Geneva: WHO. 2008.
36.
Zurück zum Zitat Andersson KM, Van Niekerk RM, Niccolai LM, et al. Sexual risk behaviour of the first cohort undergoing screening for enrollment into Phase I/II HIV vaccine trials in South Africa. Int J STD AIDS. 2009;20(2):95–101.PubMedCrossRef Andersson KM, Van Niekerk RM, Niccolai LM, et al. Sexual risk behaviour of the first cohort undergoing screening for enrollment into Phase I/II HIV vaccine trials in South Africa. Int J STD AIDS. 2009;20(2):95–101.PubMedCrossRef
37.
Zurück zum Zitat Shisana O, Rehle T, Simbayi LC, et al. South African National HIV prevalence, incidence, behaviour and communication survey, 2008: a turning tide among teenagers? Cape Town: Human Sciences Research Council Press; 2009. Shisana O, Rehle T, Simbayi LC, et al. South African National HIV prevalence, incidence, behaviour and communication survey, 2008: a turning tide among teenagers? Cape Town: Human Sciences Research Council Press; 2009.
38.
Zurück zum Zitat Shisana O, Rehle T, Simbayi LC, et al. South African National HIV prevalence, HIV incidence, behaviour and communication survey, 2005. Cape Town: Human Sciences Research Council Press; 2005. Shisana O, Rehle T, Simbayi LC, et al. South African National HIV prevalence, HIV incidence, behaviour and communication survey, 2005. Cape Town: Human Sciences Research Council Press; 2005.
39.
Zurück zum Zitat Simbayi LC, Chauveau J, Shisana O. Behavioural responses of South African youth to the HIV/AIDS epidemic: a nationwide survey. AIDS Care. 2004;16(5):605–18.PubMedCrossRef Simbayi LC, Chauveau J, Shisana O. Behavioural responses of South African youth to the HIV/AIDS epidemic: a nationwide survey. AIDS Care. 2004;16(5):605–18.PubMedCrossRef
40.
Zurück zum Zitat Pettifor AE, Rees HV, Steffenson A, et al. (2004) HIV and sexual behavior among young South Africans: a national survey of 15–24 year olds. Johannesburg: reproductive health research unit, University of the Witwatersrand; 6 Apr. Pettifor AE, Rees HV, Steffenson A, et al. (2004) HIV and sexual behavior among young South Africans: a national survey of 15–24 year olds. Johannesburg: reproductive health research unit, University of the Witwatersrand; 6 Apr.
41.
Zurück zum Zitat The Joint United Nations Programme on HIV/AIDS (UNAIDS). Report on the global AIDS epidemic. Geneva: UNAIDS; 2006. The Joint United Nations Programme on HIV/AIDS (UNAIDS). Report on the global AIDS epidemic. Geneva: UNAIDS; 2006.
42.
Zurück zum Zitat Wawer MJ, Gray RH, Sewankambo NK, et al. Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis. 2005;191(9):1403–9.PubMedCrossRef Wawer MJ, Gray RH, Sewankambo NK, et al. Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis. 2005;191(9):1403–9.PubMedCrossRef
43.
Zurück zum Zitat Mehta SD, Gray RH, Auvert B, et al. Does sex in the early period after circumcision increase HIV-seroconversion risk? Pooled analysis of adult male circumcision clinical trials. AIDS. 2009;23(12):1557–64.PubMedCrossRef Mehta SD, Gray RH, Auvert B, et al. Does sex in the early period after circumcision increase HIV-seroconversion risk? Pooled analysis of adult male circumcision clinical trials. AIDS. 2009;23(12):1557–64.PubMedCrossRef
44.
Zurück zum Zitat Kigozi G, Gray RH, Wawer MJ, et al. The safety of adult male circumcision in HIV-infected and uninfected men in Rakai, Uganda. PLoS Med. 2008;5(6):e116.PubMedCrossRef Kigozi G, Gray RH, Wawer MJ, et al. The safety of adult male circumcision in HIV-infected and uninfected men in Rakai, Uganda. PLoS Med. 2008;5(6):e116.PubMedCrossRef
45.
Zurück zum Zitat Kalichman S, Eaton L, Pinkerton S. Circumcision for HIV prevention: failure to fully account for behavioral risk compensation. PLoS Med. 2007;4(3):e138.PubMedCrossRef Kalichman S, Eaton L, Pinkerton S. Circumcision for HIV prevention: failure to fully account for behavioral risk compensation. PLoS Med. 2007;4(3):e138.PubMedCrossRef
46.
Zurück zum Zitat Bailey R, Moses S, Parker C, et al. (2008) The protective effect of male circumcision is sustained for at least 42 months: results from the Kisumu, Kenya Trial. XVII international AIDS conference. Mexico City, [abstract THAC0501]. Bailey R, Moses S, Parker C, et al. (2008) The protective effect of male circumcision is sustained for at least 42 months: results from the Kisumu, Kenya Trial. XVII international AIDS conference. Mexico City, [abstract THAC0501].
47.
Zurück zum Zitat Simonsen JN, Cameron DW, Gakinya MN, et al. Human immunodeficiency virus infection among men with sexually transmitted diseases: experience from a center in Africa. N Engl J Med. 1988;319(5):274–8.PubMedCrossRef Simonsen JN, Cameron DW, Gakinya MN, et al. Human immunodeficiency virus infection among men with sexually transmitted diseases: experience from a center in Africa. N Engl J Med. 1988;319(5):274–8.PubMedCrossRef
48.
Zurück zum Zitat Weiss HA, Quigley MA, Hayes RJ. Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis. AIDS. 2000;14(15):2361–70.PubMedCrossRef Weiss HA, Quigley MA, Hayes RJ. Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis. AIDS. 2000;14(15):2361–70.PubMedCrossRef
49.
Zurück zum Zitat Siegfried N, Muller M, Deeks J, et al. HIV and male circumcision–a systematic review with assessment of the quality of studies. Lancet Infect Dis. 2005;5(3):165–73.PubMed Siegfried N, Muller M, Deeks J, et al. HIV and male circumcision–a systematic review with assessment of the quality of studies. Lancet Infect Dis. 2005;5(3):165–73.PubMed
50.
Zurück zum Zitat Baeten JM, Richardson BA, Lavreys L, et al. Female-to-male infectivity of HIV-1 among circumcised and uncircumcised Kenyan men. J Infect Dis. 2005;191(4):546–53.PubMedCrossRef Baeten JM, Richardson BA, Lavreys L, et al. Female-to-male infectivity of HIV-1 among circumcised and uncircumcised Kenyan men. J Infect Dis. 2005;191(4):546–53.PubMedCrossRef
51.
Zurück zum Zitat Gray RH, Kiwanuka N, Quinn TC, et al. Male circumcision and HIV acquisition and transmission: cohort studies in Rakai, Uganda. AIDS. 2000;14(15):2371–81.PubMedCrossRef Gray RH, Kiwanuka N, Quinn TC, et al. Male circumcision and HIV acquisition and transmission: cohort studies in Rakai, Uganda. AIDS. 2000;14(15):2371–81.PubMedCrossRef
52.
Zurück zum Zitat Meier AS, Bukusi EA, Cohen CR, Holmes KK. Independent association of hygiene, socioeconomic status, and circumcision with reduced risk of HIV infection among Kenyan men. J Acquir Immune Defic Syndr. 2006;43(1):117–8.PubMedCrossRef Meier AS, Bukusi EA, Cohen CR, Holmes KK. Independent association of hygiene, socioeconomic status, and circumcision with reduced risk of HIV infection among Kenyan men. J Acquir Immune Defic Syndr. 2006;43(1):117–8.PubMedCrossRef
53.
Zurück zum Zitat Gray R, Azire J, Serwadda D, et al. Male circumcision and the risk of sexually transmitted infections and HIV in Rakai, Uganda. AIDS. 2004;18(18):2428–30.PubMed Gray R, Azire J, Serwadda D, et al. Male circumcision and the risk of sexually transmitted infections and HIV in Rakai, Uganda. AIDS. 2004;18(18):2428–30.PubMed
54.
Zurück zum Zitat Auvert B, Buve A, Ferry B, et al. Ecological and individual level analysis of risk factors for HIV infection in four urban populations in sub-Saharan Africa with different levels of HIV infection. AIDS. 2001;15(Suppl 4):S15–30.PubMedCrossRef Auvert B, Buve A, Ferry B, et al. Ecological and individual level analysis of risk factors for HIV infection in four urban populations in sub-Saharan Africa with different levels of HIV infection. AIDS. 2001;15(Suppl 4):S15–30.PubMedCrossRef
55.
Zurück zum Zitat Auvert B, Buve A, Lagarde E, et al. Male circumcision and HIV infection in four cities in sub-Saharan Africa. AIDS. 2001;15(Suppl 4):S31–40.PubMedCrossRef Auvert B, Buve A, Lagarde E, et al. Male circumcision and HIV infection in four cities in sub-Saharan Africa. AIDS. 2001;15(Suppl 4):S31–40.PubMedCrossRef
56.
Zurück zum Zitat Quinn TC, Wawer MJ, Sewankambo N, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. N Engl J Med. 2000;342(13):921–9.PubMedCrossRef Quinn TC, Wawer MJ, Sewankambo N, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. N Engl J Med. 2000;342(13):921–9.PubMedCrossRef
57.
Zurück zum Zitat Rennie S, Muula AS, Westreich D. Male circumcision and HIV prevention: ethical, medical and public health tradeoffs in low-income countries. J Med Ethics. 2007;33(6):357–61.PubMedCrossRef Rennie S, Muula AS, Westreich D. Male circumcision and HIV prevention: ethical, medical and public health tradeoffs in low-income countries. J Med Ethics. 2007;33(6):357–61.PubMedCrossRef
58.
Zurück zum Zitat Desai K, Boily MC, Garnett GP, Masse BR, Moses S, Bailey RC. The role of sexually transmitted infections in male circumcision effectiveness against HIV—insights from clinical trial simulation. Emerg Themes Epidemiol. 2006;3:19.PubMedCrossRef Desai K, Boily MC, Garnett GP, Masse BR, Moses S, Bailey RC. The role of sexually transmitted infections in male circumcision effectiveness against HIV—insights from clinical trial simulation. Emerg Themes Epidemiol. 2006;3:19.PubMedCrossRef
59.
Zurück zum Zitat Cohen J. Prevention cocktails: combining tools to stop HIV’s spread. Science. 2005;309(5737):1002–5.PubMedCrossRef Cohen J. Prevention cocktails: combining tools to stop HIV’s spread. Science. 2005;309(5737):1002–5.PubMedCrossRef
60.
Zurück zum Zitat Potts M, Halperin DT, Kirby D, et al. Public health: reassessing HIV prevention. Science. 2008;320(5877):749–50.PubMedCrossRef Potts M, Halperin DT, Kirby D, et al. Public health: reassessing HIV prevention. Science. 2008;320(5877):749–50.PubMedCrossRef
61.
Zurück zum Zitat Coates TJ, Richter L, Caceres C, Coates TJ, Richter L, Caceres C. Behavioural strategies to reduce HIV transmission: how to make them work better. Lancet. 2008;372(9639):669–84.PubMedCrossRef Coates TJ, Richter L, Caceres C, Coates TJ, Richter L, Caceres C. Behavioural strategies to reduce HIV transmission: how to make them work better. Lancet. 2008;372(9639):669–84.PubMedCrossRef
62.
Zurück zum Zitat de Bruyn G, Smith MD, Gray GE, et al. Circumcision for prevention against HIV: marked seasonal variation in demand and potential public sector readiness in Soweto, South Africa. Implement Sci. 2007;2:2.PubMedCrossRef de Bruyn G, Smith MD, Gray GE, et al. Circumcision for prevention against HIV: marked seasonal variation in demand and potential public sector readiness in Soweto, South Africa. Implement Sci. 2007;2:2.PubMedCrossRef
63.
Zurück zum Zitat Scott BE, Weiss HA, Viljoen JI. The acceptability of male circumcision as an HIV intervention among a rural Zulu population, Kwazulu-Natal, South Africa. AIDS Care. 2005;17(3):304–13.PubMedCrossRef Scott BE, Weiss HA, Viljoen JI. The acceptability of male circumcision as an HIV intervention among a rural Zulu population, Kwazulu-Natal, South Africa. AIDS Care. 2005;17(3):304–13.PubMedCrossRef
64.
Zurück zum Zitat Rain-Taljaard RC, Lagarde E, Taljaard DJ, et al. Potential for an intervention based on male circumcision in a South African town with high levels of HIV infection. AIDS Care. 2003;15(3):315–27.PubMedCrossRef Rain-Taljaard RC, Lagarde E, Taljaard DJ, et al. Potential for an intervention based on male circumcision in a South African town with high levels of HIV infection. AIDS Care. 2003;15(3):315–27.PubMedCrossRef
65.
Zurück zum Zitat de Bruyn G, Martinson NA, Nkala BD, et al. Uptake of male circumcision in an HIV vaccine efficacy trial. J Acquir Immune Defic Syndr. 2009;51(1):108–10.PubMedCrossRef de Bruyn G, Martinson NA, Nkala BD, et al. Uptake of male circumcision in an HIV vaccine efficacy trial. J Acquir Immune Defic Syndr. 2009;51(1):108–10.PubMedCrossRef
66.
Zurück zum Zitat Gray RH, Wawer MJ, Brookmeyer R, et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet. 2001;357(9263):1149–53.PubMedCrossRef Gray RH, Wawer MJ, Brookmeyer R, et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet. 2001;357(9263):1149–53.PubMedCrossRef
67.
Zurück zum Zitat The National Institute of Allergy and Infectious Diseases (NIAID), the National Institutes of Health (NIH), and the Department of Health and Human Services (DHHS). Workshop Summary: Scientific evidence of condom effectiveness for sexually transmitted disease (STD) prevention. Herndon, Virginia: NIAID, NIH & DHHS. 12–13 Jun 2000. The National Institute of Allergy and Infectious Diseases (NIAID), the National Institutes of Health (NIH), and the Department of Health and Human Services (DHHS). Workshop Summary: Scientific evidence of condom effectiveness for sexually transmitted disease (STD) prevention. Herndon, Virginia: NIAID, NIH & DHHS. 12–13 Jun 2000.
68.
Zurück zum Zitat Morgan D, Mahe C, Mayanja B, Okongo JM, Lubega R, Whitworth JA. HIV-1 infection in rural Africa: is there a difference in median time to AIDS and survival compared with that in industrialized countries? AIDS. 2002;16(4):597–603.PubMedCrossRef Morgan D, Mahe C, Mayanja B, Okongo JM, Lubega R, Whitworth JA. HIV-1 infection in rural Africa: is there a difference in median time to AIDS and survival compared with that in industrialized countries? AIDS. 2002;16(4):597–603.PubMedCrossRef
69.
Zurück zum Zitat Owens DK, Edwards DM, Shachter RD. Population effects of preventive and therapeutic HIV vaccines in early- and late-stage epidemics. AIDS. 1998;12(9):1057–66.PubMedCrossRef Owens DK, Edwards DM, Shachter RD. Population effects of preventive and therapeutic HIV vaccines in early- and late-stage epidemics. AIDS. 1998;12(9):1057–66.PubMedCrossRef
70.
Zurück zum Zitat Edwards DM, Shachter RD, Owens DK. A dynamic HIV-transmission model for evaluating the costs and benefits of vaccine programs. Interfaces. 1998;28(3):144–66.CrossRef Edwards DM, Shachter RD, Owens DK. A dynamic HIV-transmission model for evaluating the costs and benefits of vaccine programs. Interfaces. 1998;28(3):144–66.CrossRef
71.
Zurück zum Zitat Statistics South Africa. Mid-year population estimates, south africa: 2004. Pretoria: statistics South Africa. 27 Jul 2004. Statistics South Africa. Mid-year population estimates, south africa: 2004. Pretoria: statistics South Africa. 27 Jul 2004.
74.
Zurück zum Zitat Centre for AIDS development, research and evaluation (CADRE). HIV prevalence, incidence, behavior and communication survey 2005. Available at: www.cadre.org.za. Accessed 11 Jan 2006. Centre for AIDS development, research and evaluation (CADRE). HIV prevalence, incidence, behavior and communication survey 2005. Available at: www.​cadre.​org.​za. Accessed 11 Jan 2006.
Metadaten
Titel
Scaling Up Circumcision Programs in Southern Africa: The Potential Impact of Gender Disparities and Changes in Condom Use Behaviors on Heterosexual HIV Transmission
verfasst von
Kyeen M. Andersson
Douglas K. Owens
A. David Paltiel
Publikationsdatum
01.07.2011
Verlag
Springer US
Erschienen in
AIDS and Behavior / Ausgabe 5/2011
Print ISSN: 1090-7165
Elektronische ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-010-9784-y

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