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AIDS and Behavior
Erschienen in: AIDS and Behavior 11/2014

01.11.2014 | Original Paper

Gender-Specific Risk Factors for Virologic Failure in KwaZulu-Natal: Automobile Ownership and Financial Insecurity

verfasst von: Anna Q. Hare, Claudia E. Ordóñez, Brent A. Johnson, Carlos del Rio, Rachel A. Kearns, Baohua Wu, Jane Hampton, Peng Wu, Henry Sunpath, Vincent C. Marconi

Erschienen in: AIDS and Behavior | Ausgabe 11/2014

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Abstract

We sought to examine which socioeconomic indicators are risk factors for virologic failure among HIV-1 infected patients receiving antiretroviral therapy (ART) in KwaZulu-Natal, South Africa. A case–control study of virologic failure was conducted among patients recruited from the outpatient clinic at McCord Hospital in Durban, South Africa between October 1, 2010 and June 30, 2012. Cases were those failing first-line ART, defined as viral load >1,000 copies/mL. Univariate logistic regression was performed on sociodemographic data for the outcome of virologic failure. Variables found significant (p < 0.05) were used in multivariate models and all models were stratified by gender. Of 158 cases and 300 controls, 35 % were male and median age was 40 years. Gender stratification of models revealed automobile ownership was a risk factor among males, while variables of financial insecurity (unemployment, non-spouse family paying for care, staying with family) were risk factors for women. In this cohort, financial insecurity among women and automobile ownership among men were risk factors for virologic failure. Risk factor differences between genders demonstrate limitations of generalized risk factor analysis.
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Literatur
1.
UNAIDS Report on the Global AIDS Epidemic 2012. United Nations Programme on HIV/AIDS, 2012.
2.
Hong SN, Nachega JB, Kelley K, Bertagnolio S, Marconi V, Jordan M. The global status of HIV drug resistance: clinical and public health approaches for detection, treatment and prevention. Infect Disord Drug Targets. 2011;11(2):124–33.PubMedCrossRefPubMedCentral
3.
Nachega JB, Marconi VC, van Zyl GU, et al. HIV treatment adherence, drug resistance, virologic failure: evolving concepts. Infectious disorders—drug. Targets. 2011;11:167–74.
4.
Hong SY, Nachega JB, Kelley K, Bertagnolio S, Marconi VC, Jordan MR. The global status of HIV drug resistance: clinical and public-health approaches for detection, treatment and prevention. Infect Disord Drug Targets. 2011;11(2):124–33.PubMedCrossRefPubMedCentral
5.
Gupta RK, Jordan MR, Sultan BJ, et al. Global trends in antiretroviral resistance in treatment-naive individuals with HIV after rollout of antiretroviral treatment in resource-limited settings: a global collaborative study and meta-regression analysis. Lancet. 2012;380(9849):1250–8.PubMedCrossRefPubMedCentral
6.
Data on the size of the HIV/AIDS epidemic. World Health Organization; 2012.
7.
Gloabl AIDS Response Progress Report 2012. South Africa; 2012.
8.
Barth RE, van der Loeff MF, Schuurman R, Hoepelman AI, Wensing AM. Virological follow-up of adult patients in antiretroviral treatment programmes in sub-Saharan Africa: a systematic review. Lancet Infect Dis. 2010;10(3):155–66.PubMedCrossRef
9.
10.
Fox MP, Cutsem GV, Giddy J, et al. Rates and predictors of failure of first-line antiretroviral therapy and switch to second-line ART in South Africa. J Acquir Immune Defic Syndr. 2012;60(4):428–37.PubMedCrossRefPubMedCentral
11.
El-Khatib Z, Katzenstein D, Marrone G, et al. Adherence to drug-refill is a useful early warning indicator of virologic and immunologic failure among HIV patients on first-line ART in South Africa. PLoS One. 2011;6(3):e17518.PubMedCrossRefPubMedCentral
12.
Rice BD, Batzing-Feigenbaum J, Hosegood V, et al. Population and antenatal-based HIV prevalence estimates in a high contracepting female population in rural South Africa. BMC Public Health. 2007;7:160.PubMedCrossRefPubMedCentral
13.
Marconi VC, Sunpath H, Lu Z, et al. Prevalence of HIV-1 drug resistance after failure of a first highly active antiretroviral therapy regimen in KwaZulu Natal, South Africa. Clin Infect Dis. 2008;46(10):1589–97.PubMedCrossRefPubMedCentral
14.
Mutevedzi PC, Lessells RJ, Heller T, Barnighausen T, Cooke GS, Newell ML. Scale-up of a decentralized HIV treatment programme in rural KwaZulu-Natal, South Africa: does rapid expansion affect patient outcomes? Bull World Health Organ. 2010;88(8):593–600.PubMedCrossRefPubMedCentral
15.
Jordan MR, Bennett DE, Wainberg MA, et al. Update on World Health Organization HIV drug resistance prevention and assessment strategy: 2004–2011. Clin Infect Dis. 2012;54(Suppl 4):S245–9.PubMedCrossRefPubMedCentral
16.
Bennett DE, Jordan MR, Bertagnolio S, et al. HIV drug resistance early warning indicators in cohorts of individuals starting antiretroviral therapy between 2004 and 2009: World Health Organization global report from 50 countries. Clin Infect Dis. 2012;54(Suppl 4):S280–9.PubMedCrossRefPubMedCentral
17.
Baral S, Logie CH, Grosso A, Wirtz AL, Beyrer C. Modified social ecological model: a tool to guide the assessment of the risks and risk contexts of HIV epidemics. BMC Public Health. 2013;13:482.PubMedCrossRefPubMedCentral
18.
Kagee A, Remien R, Berkman A, Hoffman S, Campos L, Swartz L. Structural barriers to ART adherence in Southern Africa: challenges and potential ways forward. Global Public Health. 2011;6(1):83–97.PubMedCrossRefPubMedCentral
19.
Sumartojo E. Structural factors in HIV prevention: concepts, examples, and implications for research. AIDS. 2000;14(Suppl 1):S3–10.PubMedCrossRef
20.
Denton M, Prus S, Walters V. Gender differences in health: a Canadian study of the psychosocial, structural and behavioural determinants of health. Soc Sci Med. 2004;58(12):2585–600.PubMedCrossRef
21.
Parker RG, Easton D, Klein CH. Structural barriers and facilitators in HIV prevention: a review of international research. AIDS. 2000;14(Suppl 1):S22–32.PubMedCrossRef
22.
Rebolledo P, Kourbatova E, Rothenberg R, Del Rio C. Factors associated with utilization of HAART amongst hard-to-reach HIV-infected individuals in Atlanta, Georgia. J AIDS HIV Res. 2011;3(3):63–70.PubMedPubMedCentral
23.
Gruskin S, Ferguson L, Alfven T, Rugg D, Peersman G. Identifying structural barriers to an effective HIV response: using the National Composite Policy Index data to evaluate the human rights, legal and policy environment. J Int AIDS Soc. 2013;16(1):18000.PubMedCrossRefPubMedCentral
24.
Rachlis BS, Mills EJ, Cole DC. Livelihood security and adherence to antiretroviral therapy in low and middle income settings: a systematic review. PLoS One. 2011;6(5):e18948.PubMedCrossRefPubMedCentral
25.
Posse M, Meheus F, van Asten H, van der Ven A, Baltussen R. Barriers to access to antiretroviral treatment in developing countries: a review. Trop Med Int Health. 2008;13(7):904–13.PubMedCrossRef
26.
Byakika-Tusiime J, Oyugi JH, Tumwikirize WA, Katabira ET, Mugyenyi PN, Bangsberg DR. Adherence to HIV antiretroviral therapy in HIV+ Ugandan patients purchasing therapy. Int J STD AIDS. 2005;16(1):38–41.PubMedCrossRef
27.
Kagee A, Delport T. Barriers to adherence to antiretroviral treatment: the perspectives of patient advocates. J Health Psychol. 2010;15(7):1001–11.PubMedCrossRef
28.
Obiako OR, Muktar HM. Challenges of HIV treatment in resource-poor countries: a review. Niger J Med. 2010;19(4):361–8.PubMed
29.
Coetzee B, Kagee A, Vermeulen N. Structural barriers to adherence to antiretroviral therapy in a resource-constrained setting: the perspectives of health care providers. AIDS care. 2011;23(2):146–51.PubMedCrossRef
30.
Siedner MJ, Lankowski A, Tsai AC, et al. GPS-measured distance to clinic, but not self-reported transportation factors, are associated with missed HIV clinic visits in rural Uganda. AIDS. 2013;27(9):1503–8.PubMedCrossRefPubMedCentral
31.
Rosen S, Ketlhapile M, Sanne I, de Silva MB. Cost to patients of obtaining treatment for HIV/AIDS in South Africa. S Afr Med J. 2007;97(7):524–9.PubMed
32.
Hardon AP, Akurut D, Comoro C, et al. Hunger, waiting time and transport costs: time to confront challenges to ART adherence in Africa. AIDS Care. 2007;19(5):658–65.PubMedCrossRef
33.
Women’s Property Rights, HIV and AIDS, and Violence in South Africa and Uganda: Preliminary Findings. Washington, DC, USA: International Center for Research on Women (ICRW), 2007. Report no.
34.
Jewkes R, Morrell R. Gender and sexuality: emerging perspectives from the heterosexual epidemic in South Africa and implications for HIV risk and prevention. J Int AIDS Soc. 2010;13:6.PubMedPubMedCentral
35.
Dworkin SL, Grabe S, Lu T, et al. Property rights violations as a structural driver of women’s HIV risks: a qualitative study in Nyanza and Western Provinces, Kenya. Arch Sex Behav. 2013;42(5):703–13.PubMedCrossRefPubMedCentral
36.
37.
Beck D. Men and ARVs: how does being a man affect access to antiretroviral therapy in South Africa? An Investigation among Xhosa-speaking men in Khayelitsha. 2004.
38.
Dageid W, Govender K, Gordon SF. Masculinity and HIV disclosure among heterosexual South African men: implications for HIV/AIDS intervention. Cult Health Sex. 2012;14(8):925–40.PubMedCrossRef
39.
Richter L, Morrell R. Baba: men and fatherhood in South Africa. In: Richter L, Morrell R, editors. Cape Town, South Africa: Human Sciences Research Council; 2006.
40.
Skovdal M, Campbell C, Madanhire C, Mupambireyi Z, Nyamukapa C, Gregson S. Masculinity as a barrier to men’s use of HIV services in Zimbabwe. Glob Health. 2011;7:13.CrossRef
41.
Barnighausen T, editor. Unequal benefits from ART: a growing male disadvantage in life expectancy in rural South Africa. In: Conference on retroviruses and opportunistic infections, 2014 March 6, Boston; 2014.
42.
Druyts E, Dybul M, Kanters S, et al. Male sex and the risk of mortality among individuals enrolled in antiretroviral therapy programs in Africa: a systematic review and meta-analysis. AIDS. 2013;27(3):417–25.PubMedCrossRef
43.
Marconi VC, Wu B, Hampton J, et al. Early warning indicators for first-line virologic failure independent of adherence measures in a South African urban clinic. AIDS Patient Care STDS. 2013;27(12):657–68.PubMedCrossRef
44.
Marx C, Charlton S. The case of Durban, South Africa. London: UN-Habitat and University College London, Unit DP; 2003.
45.
Lehohla P. Census 2011 municipal report KwaZulu-Natal. Pretoria, South Africa; 2012.
46.
Ramirez-Avila L, Regan S, Giddy J, et al. Depressive symptoms and their impact on health-seeking behaviors in newly-diagnosed HIV-infected patients in Durban, South Africa. AIDS Behav. 2012;16(8):2226–35.PubMedCrossRefPubMedCentral
47.
National Antiretroviral Treatment Guideline. In: Department of Health SA, editor. South Africa: South African Department of Health; 2013.
48.
Rutstein S. The DHS wealth index: approaches for rural and urban areas. Working paper. Washington: United States Agency for International Development, Research DaH, Report no.: 60 contract no.: 60; 2008.
49.
Weintrob AC, Fieberg AM, Agan BK, et al. Increasing age at HIV seroconversion from 18 to 40 years is associated with favorable virologic and immunologic responses to HAART. J Acquir Immune Defic Syndr. 2008;49(1):40–7.PubMedCrossRef
50.
Greenbaum AH, Wilson LE, Keruly JC, Moore RD, Gebo KA. Effect of age and HAART regimen on clinical response in an urban cohort of HIV-infected individuals. AIDS. 2008;22(17):2331–9.PubMedCrossRefPubMedCentral
51.
Bhat VG, Ramburuth M, Singh M, et al. Factors associated with poor adherence to anti-retroviral therapy in patients attending a rural health centre in South Africa. Eur J Clin Microbiol Infect Dis. 2010;29(8):947–53.PubMedCrossRef
52.
Hawkins C, Chalamilla G, Okuma J, et al. Sex differences in antiretroviral treatment outcomes among HIV-infected adults in an urban Tanzanian setting. AIDS. 2011;25(9):1189–97.PubMedCrossRef
53.
Lima VD, Bangsberg DR, Harrigan PR, et al. Risk of viral failure declines with duration of suppression on highly active antiretroviral therapy irrespective of adherence level. J Acquir Immune Defic Syndr. 2010;55(4):460–5.PubMedCrossRefPubMedCentral
54.
Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap): a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81.PubMedCrossRefPubMedCentral
55.
Gupta GR, Parkhurst JO, Ogden JA, Aggleton P, Mahal A. Structural approaches to HIV prevention. Lancet. 2008;372(9640):764–75.PubMedCrossRef
56.
Ramadhani HO, Thielman NM, Landman KZ, et al. Predictors of incomplete adherence, virologic failure, and antiviral drug resistance among HIV-infected adults receiving antiretroviral therapy in Tanzania. Clin Infect Dis. 2007;45(11):1492–8.PubMedCrossRef
57.
Dabis F. Eearly loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income countries. Bull World Health Organ. 2008;86(7):559–67.PubMedCrossRefPubMedCentral
58.
Miller CM, Ketlhapile M, Rybasack-Smith H, Rosen S. Why are antiretroviral treatment patients lost to follow-up? A qualitative study from South Africa. Trop Med Int Health. 2010;15(Suppl 1):48–54.PubMedCrossRefPubMedCentral
59.
Topp SM, Li MS, Chipukuma JM, et al. Does provider-initiated counselling and testing (PITC) strengthen early diagnosis and treatment initiation? Results from an analysis of an urban cohort of HIV-positive patients in Lusaka, Zambia. J Int AIDS Soc. 2012;15(2):17352.PubMedCrossRefPubMedCentral
60.
Kiula ES, Damian DJ, Msuya SE. Predictors of HIV serostatus disclosure to partners among HIV-positive pregnant women in Morogoro, Tanzania. BMC Public Health. 2013;13(1):433.PubMedCrossRefPubMedCentral
61.
Stangl AL, Wamai N, Mermin J, Awor AC, Bunnell RE. Trends and predictors of quality of life among HIV-infected adults taking highly active antiretroviral therapy in rural Uganda. AIDS Care. 2007;19(5):626–36.PubMedCrossRef
62.
Martikainen P, Bartley M, Lahelma E. Psychosocial determinants of health in social epidemiology. Int J Epidemiol. 2002;31(6):1091–3.PubMedCrossRef
63.
Hiscock R, Macintyre S, Kearns A, Ellaway A. Means of transport and ontological security: do cars provide psycho-social benefits to their users? Transp Res D. 2002;7(2):119–35.CrossRef
64.
Hargreaves JR, Morison LA, Gear JSS, et al. Hearing the voices of the poor: Assigning poverty lines on the basis of local perceptions of poverty. A Quantitative Analysis of Qualitative Data from Participatory Wealth Ranking in Rural South Africa. World Dev. 2007;35(2):212–29.CrossRef
65.
Kaus W. Conspicuous consumption and “race”: evidence from South Africa. J Dev Econ. 2013;100(1):63–73.CrossRef
66.
Ragnarsson A, Townsend L, Ekstrom AM, Chopra M, Thorson A. The construction of an idealised urban masculinity among men with concurrent sexual partners in a South African township. Global Health Action. 2010;3:5092.CrossRef
67.
Ellaway A, Macintyre S, Hiscock R, Kearns A. In the driving seat: psychosocial benefits from private motor vehicle transport compared to public transport. Transp Res F. 2003;6(3):217–31.CrossRef
68.
Vick M. Danger on roads: masculinity, the car, and safety. Youth Stud Aust. 2003;22(1):32–7.
69.
Siu GE, Wight D, Seeley J. How a masculine work ethic and economic circumstances affect uptake of HIV treatment: experiences of men from an artisanal gold mining community in rural eastern Uganda. J Int AIDS Soc. 2012;15(Suppl 1):1–9.PubMed
70.
Lynch I, Brouard PW, Visser MJ. Constructions of masculinity among a group of South African men living with HIV/AIDS: reflections on resistance and change. Cult Health Sex. 2010;12(1):15–27.PubMedCrossRef
71.
Mfecane S. Narratives of HIV disclosure and masculinity in a South African village. Cult Health Sex. 2012;14(Suppl 1):S109–21.PubMedCrossRef
72.
Hadebe L. Zulu masculinity: culture, faith and the constitution in the South African context. Pietermaritzburg: University of KwaZulu-Natal; 2010.
73.
Mfecane S. Living with HIV as a man: implications for masculinity. Psychol Soc. 2008;36:45–59.
74.
Fitzgerald M, Collumbien M, Hosegood V. No one can ask me ‘Why do you take that stuff?’: men’s experiences of antiretroviral treatment in South Africa. AIDS Care. 2010;22(3):355–60.PubMedCrossRef
75.
Mantell JE, Needham SL, Smit JA, et al. Gender norms in South Africa: implications for HIV and pregnancy prevention among African and Indian women students at a South African tertiary institution. Cult Health Sex. 2009;11(2):139–57.PubMedCrossRefPubMedCentral
76.
Harrison A, O’Sullivan LF, Hoffman S, Dolezal C, Morrell R. Gender role and relationship norms among young adults in South Africa: measuring the context of masculinity and HIV risk. J Urban Health. 2006;83(4):709–22.PubMedCrossRefPubMedCentral
77.
Barker G, Ricardo C. Young men and the construction of masculinity in sub-Saharan Africa: implications for HIV/AIDS, conflict, and violence. The World Bank, June 2005. Report no.: 32712.
78.
79.
Kunutsor S, Walley J, Katabira E, et al. Improving clinic attendance and adherence to antiretroviral therapy through a treatment supporter intervention in Uganda: a randomized controlled trial. AIDS Behav. 2011;15(8):1795–802.PubMedCrossRef
80.
Igumbor JO, Scheepers E, Ebrahim R, Jason A, Grimwood A. An evaluation of the impact of a community-based adherence support programme on ART outcomes in selected government HIV treatment sites in South Africa. AIDS Care. 2011;23(2):231–6.PubMedCrossRef
81.
Kabore I, Bloem J, Etheredge G, et al. The effect of community-based support services on clinical efficacy and health-related quality of life in HIV/AIDS patients in resource-limited settings in sub-Saharan Africa. AIDS Patient Care STDS. 2010;24(9):581–94.PubMedCrossRef
82.
Peltzer K. HIV-related symptoms and management in HIV and antiretroviral therapy patients in KwaZulu-Natal, South Africa: a longitudinal study. SAHARA J. 2013;10(2):96–104.PubMedCrossRefPubMedCentral
Metadaten
Titel
Gender-Specific Risk Factors for Virologic Failure in KwaZulu-Natal: Automobile Ownership and Financial Insecurity
verfasst von
Anna Q. Hare
Claudia E. Ordóñez
Brent A. Johnson
Carlos del Rio
Rachel A. Kearns
Baohua Wu
Jane Hampton
Peng Wu
Henry Sunpath
Vincent C. Marconi
Publikationsdatum
01.11.2014
Verlag
Springer US
Erschienen in
AIDS and Behavior / Ausgabe 11/2014
Print ISSN: 1090-7165
Elektronische ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-014-0849-1

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