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Journal of Inherited Metabolic Disease

Erschienen in:

01.01.2015 | COMPLEX LIPIDS

Principles and practice of lipidomics

verfasst von: Frédéric M. Vaz, Mia Pras-Raves, Albert H. Bootsma, Antoine H. C. van Kampen

Erschienen in: Journal of Inherited Metabolic Disease | Ausgabe 1/2015

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Abstract

The technical advances in mass spectrometry, particularly the development of (ultra)-high-resolution/mass accuracy measurement capabilities in combination with refinement of soft ionization techniques, have increased the application and success of lipidomics to answer biological questions in relation to lipid metabolism. Together with other omics technologies, lipidomics has become an important tool to practice systems biology as lipids comprise a very significant part of the metabolome and play pleiotropic roles in cellular functions. As an increasing number of disorders are linked to lipid metabolism, lipidomics is used to search for biomarkers, understand disease mechanism and follow the efficacy of therapeutic options. This review provides a first introduction to the major methodological strategies currently used for mass spectrometry-based lipidomics and associated data pre-processing and analysis.

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Titel: Principles and practice of lipidomics
verfasst von: Frédéric M. Vaz
Mia Pras-Raves
Albert H. Bootsma
Antoine H. C. van Kampen
Publikationsdatum: 01.01.2015
Verlag: Springer Netherlands
Erschienen in: Journal of Inherited Metabolic Disease / Ausgabe 1/2015
Print ISSN: 0141-8955
Elektronische ISSN: 1573-2665
DOI: https://doi.org/10.1007/s10545-014-9792-6

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