nach oben

Brain Topography

Erschienen in:

01.01.2015 | Original Paper

Increased Gamma Oscillations Evoked by Physically Salient Distracters are Associated with Schizotypy

verfasst von: Laura Kornmayer, Gregor Leicht, Christoph Mulert

Erschienen in: Brain Topography | Ausgabe 1/2015

Einloggen, um Zugang zu erhalten

Abstract

Over the last decade, there has been growing interest in aberrant salience as a precursor of positive symptoms in schizophrenia. The present study investigates the neurophysiology of attentional capture by salient stimuli in the visual modality. Evoked oscillatory activity in the gamma frequency range (40 Hz) was assessed during visual processing of physically salient distracters and evaluated in relation to schizotypy and its positive, negative and disorganized dimension. The early evoked visual gamma-band response (GBR) was assessed for 24 healthy participants using EEG time–frequency analysis. Physical salience was constituted by colored stimuli diverting from an ongoing baseline condition. schizotypal personality traits were measured by the schizotypal personality questionnaire (SPQ; Raine in Schizophr Bull 17:555–564, 1991). The early evoked visual GBR was significantly pronounced in the physically salient distracter condition. GBR signal power was significantly correlated with positive schizotypal personality traits (r = 0.588; p = 0.024*). Our results indicate that the early evoked GBR in visual processing of physically salient distracters is associated with schizotypy. These findings refer to the phenomenology of aberrant salience by bridging the gap to neurophysiological research on early sensory selection and attentional capture in the schizophrenia spectrum.

Andreou C, Nolte G, Leicht G, Polomac N, Hanganu-Opatz IL, Lambert M, Engel AK, Mulert C (2014). Increased resting-state gamma-band connectivity in first-episode schizophrenia. Schizophr Bull. doi:10.1093/schbul/sbu121

Anscombe R (1987) The disorder of consciousness in schizophrenia. Schizophr Bull 13(2):241–260PubMedCrossRef

Basar-Eroglu C, Brand A, Hildebrandt H, Kedzior KK, Mathes B (2007) Working memory related gamma oscillations in schizophrenia patients. Int J Psychophysiol 64:39–45PubMedCrossRef

Bosman CA, Schoffelen J-M, Brunet N, Oostenveld R, Bastos AM, Womelsdorf T, Rubehn B, Stieglitz T, De Weerd P, Fries P (2012) Attentional stimulus selection through selective synchronization between monkey visual areas. Neuron 75:875–888PubMedCentralPubMedCrossRef

Busch NA, Debener S, Kranczioch C, Engel AK, Herrmann CS (2004) Size matters: effects of stimulus size, duration and eccentricity on the visual gamma-band response. Clin Neurophysiol 115(8):1810–1820PubMedCrossRef

Busch NA, Schadow J, Fründ I, Herrmann CS (2006) Time-frequency analysis of target detection reveals an early interface between bottom-up and top-down processes in the gamma-band. Neuroimage 29(4):1106–1116PubMedCrossRef

Buzsaki G, Draghun A (2004) Neural oscillations in cortical networks. Science 304:1926–1929PubMedCrossRef

Carl C, Açık A, König P, Engel AK, Hipp JF (2012) The saccadic spike artifact in MEG. Neuroimage 59(2):1657–1667PubMedCrossRef

Chen C-M, Stanford AD, Mao X, Abi-Dargham A, Shungu DC, Lisanby SH, Schroeder CE, Kegeles LS (2014) GABA level, gamma oscillation, and working memory performance in schizophrenia. Neuroimage Clin 4:531–539PubMedCentralPubMedCrossRef

Gallinat J, Winterer G, Herrmann CS, Senkowski D (2004) Reduced oscillatory gamma-band responses in unmedicated schizophrenic patients indicate impaired frontal network processing. Clin Neurophysiol 115:1863–1874PubMedCrossRef

Gonzalez-Burgos G, Lewis D (2008) GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunctions in schizophrenia. Schizophr Bull 34:944–961PubMedCentralPubMedCrossRef

Gordon E, Williams L, Haig AR, Wright J, Meares RA (2001) Symptom profile and “gamma” processing in schizophrenia. Cogn Neuropsychiatry 6(1):7–19

Gradin VB, Waiter G, O’Connor A, Romaniuk L, Stickle C, Matthews K, Hall J, Steele JD (2012) Salience network-midbrain dysconnectivity and blunted reward signals in schizophrenia. Psychiatry Res 211:104–111PubMedCrossRef

Gruber T, Müller MM, Keil A, Elbert T (1999) Selective visual-spatial attention alters induced gamma band responses in the human EEG. Clin Neurophysiol 110(12):2074–2085PubMedCrossRef

Haenschel C, Bittner RA, Waltz J, Haertling F, Wibral M, Singer W, Linden DEJ, Rodriguez E (2009) Cortical oscillatory activity is critical for working memory as revealed by deficits in early-onset schizophrenia. J Neurosci 29(30):9481–9489PubMedCrossRef

Hahn B, Robinson BM, Kaiser ST, Harvey AN, Beck VM, Leonard CJ, Kappenman ES, Luck SJ, Gold JM (2010) Failure of schizophrenia patients to overcome salient distractors during working memory encoding. Biol Psychiatry 68(7):603–609PubMedCentralPubMedCrossRef

Herrmann CS, Mecklinger A (2001) Gamma activity in human EEG is related to highspeed memory comparisons during object selective attention. Vis Cogn 8(3–5):593–608CrossRef

Herrmann CS, Mecklinger AM, Pfeifer E (1999) Gamma responses and ERPs in a visual classification task. Clin Neurophysiol 110:636–642

Herrmann CS, Munk MHJ, Engel AK (2004) Cognitive functions of gamma-band activity: memory match and utilization. Trends in Cogn Sci 8(8):347–355CrossRef

Herrmann CS, Grigutsch M, Busch NA (2005) EEG oscillations and wavelet analysis. In: Todd CH (ed) Event-related potentials: a methods handbook. MIT Press, Cambridge

Jokeit H, Makeig S (1994) Different event-related patterns of γ-band power in brain waves of fast and slow-reacting subjects. Proc Natl Acad Sci USA 91:6339–6343PubMedCentralPubMedCrossRef

Kapur S (2003) Psychosis as a state of aberrant salience: a framework linking biology, phenomenolo-gy, and pharmacology in schizophrenia. Am J Psychiatry 160(1):13–23PubMedCrossRef

Kapur S (2005) From dopamine to salience to psychosis—linking biology, pharmacology and phenomenology of psychosis. Schizophr Res 79:59–68PubMedCrossRef

Karakas S, Basar E (1998) Early gamma response is sensory in origin: a conclusion based on cross-comparison of results from multiple experimental paradigms. Int J Psychophysiol 31(1):13–31PubMedCrossRef

Karakas S, Basar-Eroglu C, Özesmi C, Kafadar H, Erzengin ÖÜ (2001) Gamma response of the brain: a multifunctional oscillation that represents bottom-up with top-down processing. Int J Psychophysiol 39:137–150PubMedCrossRef

Klosterkötter J, Hellmich M, Steinmeyer EM, Schultze-Luttner F (2001) Diagnosing schizophrenia in the initial prodromal phase. Arch Gen Psychiatry 58:158–164PubMedCrossRef

Kömek K, Ermentrout GB, Walter CP, Cho RY (2012) Dopamine and gamma band synchrony in schizophrenia—insights from computational and empirical studies. Eur J Neurosci 36:2146–2155PubMedCentralPubMedCrossRef

Koychev I, Deakin JFW, Haenschel C, El-Deredy W (2011) Abnormal neural oscillations in schizotypy during a visual working memory task: support for a deficient top-down network? Neuropsychologia 49(10):2866–2873PubMedCrossRef

Krishnan GP, Vohs JL, Hetrick WP, Carroll CA, Shekhar A, Bockbrader MA, O’Donnell BF (2005) Steady state visual evoked potential abnormalities in schizophrenia. Clin Neurophysiol 116(3):614–624PubMedCrossRef

Lee K-H, Williams LM, Breakspear M, Gordon E (2003) Synchronous gamma activity: a review and contribution to an integrative neuroscience model of schizophrenia. Brain Res Rev 41(1):57–78PubMedCrossRef

Leicht G, Kirsch V, Giegling I, Karch S, Hantschk I, Möller H-J, Pogarell O, Hegerl U, Rujescu D, Mulert C (2010) Reduced early auditory evoked gamma-band response in patients with schizophrenia. Biol Psychiatry 67(3):224–231PubMedCrossRef

Leicht G, Karch S, Karamatskos E, Giegling I, Möller H-J, Hegerl U, Pogarell O, Rujescu D, Mulert C (2011) Alterations of the early auditory evoked gamma-band response in first-degree relatives of patients with schizophrenia: hints to a new intermediate phenotype. J Psychiatr Res 45:699–705PubMedCrossRef

Linney YM, Murray RM, Peters ER, MacDonald AM, Rijsdijk F, Sham PC (2003) A quantitative genetic analysis of schizotypal personality traits. Psychol Med 33(5):803–816PubMedCrossRef

Lisman JE, Coyle JT, Green RW, Javitt DC, Benes FM, Heckers S, Grace AA (2008) Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neurosci 31(5):234–242PubMedCentralPubMedCrossRef

Minzenberg MJ, Firl AJ, Yoon JH, Gomes GC, Reinking G, Carter CS (2010) Gamma oscillatory power is impaired during cognitive control independent of medication status in first-episode schizophrenia. Neuropsychopharmacology 35:2590–2599PubMedCentralPubMedCrossRef

Mishara AL, Fusar-Poli P (2013) The phenomenology and neurobiology of delusion formation during psychosis onset: Jaspers, Truman symptoms, and aberrant salience. Schizophr Bull 39(2):278–286PubMedCentralPubMedCrossRef

Mulert C, Leicht G, Pogarell O, Mergl R, Karch S, Juckel G, Möller H-J, Hegerl U (2007) Auditory cortex and anterior cingulate cortex sources of the early evoked gamma-band response: relationship to task difficulty and mental effort. Neuropsychologia 45:2294–2306PubMedCrossRef

Mulert C, Leicht G, Hepp P, Kirsch V, Karch S, Pogarell O, Reiser M, Hegerl U, Jäger L, Moller HJ, McCarley RW (2010) Single-trial coupling of the gamma-band response and the corresponding BOLD signal. Neuroimage 49:2238–2247PubMedCrossRef

Mulert C, Kirsch V, Pascual-Marqui R, McCarley RW, Spencer KM (2011) Long-range synchrony of gamma oscillations and auditory hallucination symptoms in schizophrenia. Int J Psychophysiol 79(1):55–63PubMedCentralPubMedCrossRef

Murray GK, Corlett PR, Clark L, Pessiglione M, Blackwell AD, Honey G, Jones PB, Bullmore ET, Robbins TW, Fletcher PC (2008) Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Mol Psychiatry 13:267–276CrossRef

Palaniyappan L, Liddle PF (2012) Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction. J Psychiatry Neurosci 37(1):17–27PubMedCentralPubMedCrossRef

Raine A (1991) The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr Bull 17(4):555–564PubMedCrossRef

Raine A, Reynolds C, Lencz T, Scerbo A, Triphon N, Kim D (1994) Cognitive-perceptual, interpersonal and disorganized features of schizotypal personality. Schizophr Bull 20(1):191–201PubMedCrossRef

Roiser JP, Howes OD, Chaddock CA, Joyce EM, McGuire P (2013) Neural and behavioral correlates of aberrant salience in individuals at risk for psychosis. Schizophr Bull 39(6):1328–1336

Roiser JP, Stephan KE, den Ouden HEM, Barnes TRE, Friston KJ, Joyce EM (2009) Do patients with schizophrenia exhibit aberrant salience? Psychol Med 39:199–209

Schneider TR, Debener S, Oostenveld R, Engel AK (2008) Enhanced EEG gamma-band activity reflects multisensory semantic matching in visual-to-auditory object priming. Neuroimage 42(3):1244–1254PubMedCrossRef

Senkowski D, Herrmann CS (2002) Effects of task difficulty on evoked gamma activity and ERPs in a visual discrimination task. Clin Neurophysiol 113(11):1742–1753PubMedCrossRef

Sommer IEC, Diederen KMJ, Blom J-D, Willems A, Kushan L, Slotema K, Boks KPM, Daalman K, Hoek HW, Neggers SFW (2008) Auditory verbal hallucinations predominantly activate the right inferior frontal area. Brain 131(12):3169–3177PubMedCrossRef

Spencer KM, Nestor PG, Perlmutter R, Niznikiewicz MA, Klump MC, Frumin M, Shenton ME, McCarley RW (2004) Neural synchrony indexes disordered perception and cognition in schizophrenia. Proc Natl Acad Sci USA 101(49):17288–17293PubMedCentralPubMedCrossRef

Spencer KM, Salisbury DF, Shenton ME, McCarley RW (2008) γ-Band auditory steady-state responses are impaired in first episode psychosis. Biol Psychiatry 64(5):369–375PubMedCentralPubMedCrossRef

Spencer KM, Niznikiewicz MA, Nestor PG, Shenton ME, McCarley RW (2009) Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia. BMC Neurosci 10:85PubMedCentralPubMedCrossRef

Tallon-Baudry C, Bertrand O, Peronnet F, Pernier J (1998) Induced γ-band activity during the delay of a visual short-term memory task in humans. J Neurosci 18(11):4244–4254PubMed

Teising M (2005) Permeability and demarcation in the psychoanalytic process. Functions of the contact-barrier. Int J Psychoanal 86:1627–1644PubMed

Uhlhaas PJ, Singer W (2010) Abnormal neural oscillations and synchrony in schizophrenia. Nat Rev Neurosci 11(2):100–113PubMedCrossRef

Yoon JH, Maddock RJ, Rokem A, Silver MA, Minzenberg MJ, Ragland JD, Carter CS (2010) GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression. J Neurosci 30(10):3777–3781PubMedCentralPubMedCrossRef

Titel: Increased Gamma Oscillations Evoked by Physically Salient Distracters are Associated with Schizotypy
verfasst von: Laura Kornmayer
Gregor Leicht
Christoph Mulert
Publikationsdatum: 01.01.2015
Verlag: Springer US
Erschienen in: Brain Topography / Ausgabe 1/2015
Print ISSN: 0896-0267
Elektronische ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-014-0418-y

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Viertel reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Bluttest erkennt Parkinson schon zehn Jahre vor der Diagnose

10.05.2024 Parkinson-Krankheit Nachrichten

Ein Bluttest kann abnorm aggregiertes Alpha-Synuclein bei einigen Menschen schon zehn Jahre vor Beginn der motorischen Parkinsonsymptome nachweisen. Mit einem solchen Test lassen sich möglicherweise Prodromalstadien erfassen und die Betroffenen früher behandeln.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Wartezeit nicht kürzer, aber Arbeit flexibler

Psychotherapie Medizin aktuell

Fünf Jahren nach der Neugestaltung der Psychotherapie-Richtlinie wurden jetzt die Effekte der vorgenommenen Änderungen ausgewertet. Das Hauptziel der Novellierung war eine kürzere Wartezeit auf Therapieplätze. Dieses Ziel wurde nicht erreicht, es gab jedoch positive Auswirkungen auf andere Bereiche.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2015

Detection of Interictal Epileptiform Discharges Using Signal Envelope Distribution Modelling: Application to Epileptic and Non-Epileptic Intracranial Recordings

Motor Abnormalities and Basal Ganglia in Schizophrenia: Evidence from Structural Magnetic Resonance Imaging

Catching the Invisible: Mesial Temporal Source Contribution to Simultaneous EEG and SEEG Recordings

Magnetic Source Imaging in Posterior Cortex Epilepsies

Early and Late Age of Seizure Onset have a Differential Impact on Brain Resting-State Organization in Temporal Lobe Epilepsy