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01.10.2007 | Epidemiology

Weight gain and recovery of pre-cancer weight after breast cancer treatments: evidence from the women’s healthy eating and living (WHEL) study

verfasst von: Nazmus Saquib, Shirley W. Flatt, Loki Natarajan, Cynthia A. Thomson, Wayne A. Bardwell, Bette Caan, Cheryl L. Rock, John P. Pierce

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2007

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Abstract

Purpose

To examine predictors of weight gain following breast cancer diagnosis and subsequent return to pre-cancer weight.

Objectives

To determine (1) the associations of anti-neoplastic chemotherapy and/or, Tamoxifen^® therapy on weight change following breast cancer diagnosis, (2) whether chemotherapy modified the effect of specific demographic and tumor characteristics on weight gain, (3) the proportion and characteristics of women who gained significant weight on chemotherapy and returned to their pre-cancer weight during follow-up.

Subjects and methods

Participants were 3088 breast cancer survivors, aged 27–74 years. Weight was measured at baseline and years 1 through 6; pre-cancer weight was self-reported. Cancer stage and treatment modalities were obtained by medical record review; demographic and physical activity data were obtained from questionnaires. Weight gain of ≥5% body weight following cancer diagnosis was considered significant.

Results

Chemotherapy was significantly associated with weight gain (OR = 1.65, 95% CI = 1.12, 2.43) and Tamoxifen^® was not (OR = 1.03, 95% CI = 0.71, 1.51). Tamoxifen^® did not modify the effect of either chemotherapy or its different regimens on weight gain. Both types (anthracycline: OR = 1.63, p-value = 0.01, non-anthracycline: OR = 1.79, p = 0.003) and all regimens of chemotherapy (AC: OR = 1.55, p-value = 0.01, CAF: OR = 1.83, p = 0.003, CMF: OR = 1.76, p = 0.004) were associated with weight gain but the associations were not different from one another. Only 10% of participants returned to their pre-cancer diagnosis weight at the follow-up visits; the degree of initial gain (p for trend <0.0001) predicted that return.

Conclusion

Chemotherapy was associated with clinically meaningful weight gain, and a return to initial weight following weight gain was unlikely.

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Titel: Weight gain and recovery of pre-cancer weight after breast cancer treatments: evidence from the women’s healthy eating and living (WHEL) study
verfasst von: Nazmus Saquib
Shirley W. Flatt
Loki Natarajan
Cynthia A. Thomson
Wayne A. Bardwell
Bette Caan
Cheryl L. Rock
John P. Pierce
Publikationsdatum: 01.10.2007
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 2/2007
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-006-9442-2

Springer Medizin

Weight gain and recovery of pre-cancer weight after breast cancer treatments: evidence from the women’s healthy eating and living (WHEL) study