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01.12.2007 | Preclinical Study/Clinical Trial/Epidemiology/Invited Comentary

Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive ²³Na MRI

verfasst von: Ronald Ouwerkerk, Michael A. Jacobs, Katarzyna J. Macura, Antonio C. Wolff, Vered Stearns, Sarah D. Mezban, Nagi F. Khouri, David A. Bluemke, Paul A. Bottomley

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2007

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Abstract

Background

The hypothesis that physiological and biochemical changes associated with proliferating malignant tumors may cause an increase in total tissue sodium concentration (TSC) was tested with non-invasive, quantitative sodium (²³Na) magnetic resonance imaging (MRI) in patients with benign and malignant breast tumors.

Methods

²³Na and ¹H MRI of the breast was performed on 22 women with suspicious breast lesions (≥1 cm) at 1.5 Tesla. A commercial proton (¹H) phased array breast coil and custom solenoidal ²³Na coil were used to acquire ¹H and ²³Na images during the same MRI examination. Quantitative 3-dimensional ²³Na projection imaging was implemented with negligible signal loss from MRI relaxation, or from radio-frequency field inhomogeneity, in less than 15 min. Co-registered ¹H and ²³Na images permitted quantification of TSC in normal and suspicious tissues on the basis of ¹H MRI contrast enhancement and anatomy, with histology confirmed by biopsy.

Results

Sodium concentrations were consistently elevated in (N = 19) histologically proven malignant breast lesions by an average of 63% compared to glandular tissue. The increase in sodium concentration in malignant tissue was highly significant compared to unaffected glandular tissue (P < 0.0001, paired t-test), adipose tissue, and TSC in three patients with benign lesions.

Conclusion

Elevated TSC in breast lesions measured by non-invasive ²³Na MRI appears to be a cellular-level indicator associated with malignancy. This method may have potential to improve the specificity of breast MRI with only a modest increase in scan time per patient.

ACR BI-RADS Breast Imaging Reporting and Data System, American College of Radiology.

Assuming TSC = (1−EVF)·[Na]_in + EVF·[Na]_ex with EVF = 1−IVF.

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Titel: Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRI
verfasst von: Ronald Ouwerkerk
Michael A. Jacobs
Katarzyna J. Macura
Antonio C. Wolff
Vered Stearns
Sarah D. Mezban
Nagi F. Khouri
David A. Bluemke
Paul A. Bottomley
Publikationsdatum: 01.12.2007
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 2/2007
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-006-9485-4

Springer Medizin

Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive ²³Na MRI