nach oben

01.03.2008 | Review

Symptoms after breast cancer treatment: are they influenced by patient characteristics?

verfasst von: Jean Yoon, Jennifer L. Malin, May Lin Tao, Diana M. Tisnado, John L. Adams, Martha J. Timmer, Patricia A. Ganz, Katherine L. Kahn

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2008

Einloggen, um Zugang zu erhalten

Abstract

Purpose

This study examines the burden of symptoms by treatment type and patient characteristics in a population-based sample of newly diagnosed breast cancer patients.

Methods

Using the Los Angeles County SEER Registry Rapid Case Ascertainment, we identified a cohort of breast cancer patients in 2000 and conducted telephone surveys in English and Spanish among participants.

Results

We completed interviews of 1,219 breast cancer patients and found almost half (46%) had at least one severe symptom (any of the following: nausea/vomiting, arm problems, hot flashes, vaginal dryness, difficulty sleeping) that interfered with her daily functioning or mood. Multi-variate analysis controlling for patient characteristics and treatment showed that older (OR = 0.90; P < 0.000), black (OR = 0.50; P < 0.000), Hispanic Spanish-speaking (OR = 0.37; P < 0.000), widowed or never married (OR = 0.68; P = 0.049), and working (OR = 0.72; P = 0.024) women were less likely to report severe symptoms than other women. Number of comorbid conditions (OR = 1.21; P < 0.000) and receipt of chemotherapy (OR = 1.48; P = 0.040) were positively associated with reporting symptoms.

Conclusion

These findings estimate the prevalence of several mutable symptoms in breast cancer patients that can be addressed by appropriate treatments. Comorbidity is a significant predictor of symptoms, especially amongst those receiving chemotherapy. Variation in symptom reporting occurred by race/ethnicity and other sociodemographic characteristics, raising questions of different thresholds for reporting symptoms or truly fewer symptoms for some sociodemographic groups. Population-based estimates of the probability of symptoms in women with incident breast cancer can be used to provide patient education about potential outcomes following the treatment of breast cancer.

Nur mit Berechtigung zugänglich

Ries LAG, Eisner MP, Kosary CL et al (eds) (2005) SEER cancer statistics review, 1975–2002, national cancer institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2002/, based on November 2004 SEER data submission, posted to the SEER web site 2005

Smith KW, Avis NE, Assmann SF (1999) Distinguishing between quality of life and health status in quality of life research: a meta-analysis. Qual Life Res 8(5):447–459PubMedCrossRef

Ganz PA, Rowland JH, Meyerowitz BE et al (1998) Impact of different adjuvant therapy strategies on quality of life in breast cancer survivors. Recent Results Cancer Res 152:396–411PubMed

Lindley C, Vasa S, Sawyer WT et al (1998) Quality of life and preferences for treatment following systemic adjuvant therapy for early-stage breast cancer. J Clin Oncol 16(4):1380–1387PubMed

Janz NK, Mujahid M, Lantz PM et al (2005) Population-based study of the relationship of treatment and sociodemographics on quality of life for early stage breast cancer. Qual Life Res 14:1467–1479PubMedCrossRef

Love RR, Cameron L, Connell BL et al (1991) Symptoms associated with tamoxifen treatment in postmenopausal women. Arch Int Med 151:1842–1847CrossRef

Ganz PA, Rowland JH, Meyerowitz BE et al (1998) Impact of different adjuvant therapy strategies on quality of life in breast cancer survivors. Recent Results Cancer Res 152:396–411PubMed

Sadler IJ, Jacobsen PB (2001) Progress in understanding fatigue associated with breast cancer treatment. Cancer Invest 19:723PubMedCrossRef

Wood WC, Budman DR, Korzun AH et al (1994) Dose and dose intensity of adjuvant chemotherapy for stage II, node-positive breast carcinoma. N Engl J Med 330:1253PubMedCrossRef

10.

Ganz PA, Rowland JH, Meyerowitz BE et al (1998) Impact of different adjuvant therapy strategies on quality of life in breast cancer survivors. Recent Results Cancer Res 152:396–411PubMed

11.

Stanton AL, Bernaards CA, Ganz PA (2005) The BCPT symptom scales: a measure of physical symptoms for women diagnosed with or at risk for breast cancer. J Natl Cancer Inst 97(6):448–456PubMedCrossRef

12.

Lash TL, Silliman RA (2000) Patient characteristics and treatments associated with a decline in upper-body function following breast cancer therapy. J Clin Epidemiol 53:615PubMedCrossRef

13.

de Haes JC, Curran D, Aaronson NK et al (2003) Quality of life in breast cancer patients aged over 70 years, participating in the EORTC 10850 randomised clinical trial. Eur J Cancer 39(7):945–951PubMedCrossRef

14.

Deutsch M, Flickinger JC (2001) Shoulder and arm problems after radiotherapy for primary breast cancer. Am J Clin Oncol 24(2):172–176PubMedCrossRef

15.

Erickson VS, Pearson ML, Ganz PA et al (2001) Arm edema in breast cancer patients. J Natl Cancer Inst 93(2):96–111PubMedCrossRef

16.

Knobf MT, Sun Y (2005) A longitudinal study of symptoms and self-care activities in women treated with primary radiotherapy for breast cancer. Cancer Nurs 28(3):210–218PubMedCrossRef

17.

18.

Kenefick AL (2006) Patterns of symptom distress in older women after surgical treatment for breast cancer. Oncol Nurs Forum 33(2):327–335PubMedCrossRef

19.

Ganz PA, Day R, Ware JE Jr et al (1995) Base-line quality-of-life assessment in the national surgical adjuvant breast and bowel project breast cancer prevention trial. J Natl Cancer Inst 87:1372–1382PubMedCrossRef

20.

Bromberger JT, Meyer PM, Kravitz HM et al (2001) Psychologic distress and natural menopause: a multiethnic community study. Am J Public Health 91:1435–1442PubMed

21.

Kurtz ME, Kurt JC, Stommel M et al (1999) The influence of symptoms, age, comorbidity, and cancer site on physical functioning and mental health of geriatric women patients. Women Health 29(3):1–12PubMedCrossRef

22.

23.

Deutsch M, Flickinger JC (2001) Shoulder and arm problems after radiotherapy for primary breast cancer. Am J Clin Oncol 24(2):172–176PubMedCrossRef

24.

Ashing-Giwa K, Ganz PA, Petersen L (1999) Quality of life of African-Americans and white long term breast carcinoma survivors. Cancer 85:418–426 [Erratum, Cancer 86:732–733]PubMedCrossRef

25.

King CR (1997) Nonpharmacologic management of chemotherapy-induced nausea and vomiting. Oncol Nurs Forum 24(Suppl 7):41–48PubMed

26.

Gralla RJ, Osoba D, Kris MG et al (1999) Recommendations for the use of antiemetics: evidence-based, clinical practice guidelines. J Clin Oncol 17:2971–2994PubMed

27.

Clark J, Cunningham M, McMillan S et al (2004) Sleep-wake disturbances in people with cancer part II: evaluating the evidence for clinical decision making. Oncol Nurs Forum 31:747–771PubMedCrossRef

28.

Oncology Nursing Society (ONS) (2005) Chemotherapy and biotherapy guidelines and recommendations for practice, 2nd edn. Oncology Nursing Society (ONS), Pittsburgh (PA). p 246

29.

McGuire H, Hawton K (2003) Interventions for vaginismus. Cochrane Database Syst Rev CD001760

30.

Harris SR, Hugi MR, Olivotto IA et al (2001) Clinical practice guidelines for the care and treatment of breast cancer: 11. Lymphedema. CMAJ 164:191

31.

Kahn KL, MacLean CH, Liu H et al (2007) The complexity of care for patients with rheumatoid arthritis: metrics for better understanding chronic disease care. Med Care 45(1):55–65PubMedCrossRef

32.

White H (1980) A heteroskedasticity-consistent covariace matrix estimator and a direct test for heteroskedasticity. Econometrica 48:817–830CrossRef

33.

34.

Elmore JG, Nakano CY, Linden HM et al (2005) Racial inequities in the timing of breast cancer detection, diagnosis, and initiation of treatment. Med Care 43(2):141–148PubMedCrossRef

35.

Ghafoor A, Jemal A, Ward E et al (2003) Trends in cancer by race and ethnicity. CA Cancer J Clin 53:342–355PubMedCrossRef

36.

Shavers VL, Brown ML (2002) Racial and ethnic disparities in the receipt of cancer treatment. J Natl Cancer Inst 94:334–357PubMed

37.

Shavers VL, Harlan LC, Stevens JL (2003) Racial/ethnic variation in clinical presentation, treatment, and survival among breast cancer patients under age 35. Cancer 97:134–147PubMedCrossRef

38.

Giedzinska AS, Meyerowitz BE, Ganz PA et al (2004) Health-related quality of life in a multiethnic sample of breast cancer survivors. Ann Behav Med 28(1):39–51PubMedCrossRef

39.

Avis NE, Stellato R, Crawford S et al (2001) Is there a menopausal syndrome? Menopausal status and symptoms across racial/ethnic groups. Soc Sci Med 52(3):345–356PubMedCrossRef

40.

Johnson TP, O’Rourke D, Chavez N, Sudman S (1996) Cultural variations in the interpretation of health survey questions. In: Warnecke RB (ed) Health Survey Research Methods, National Center for Health Statistics, Hyattsville, MD, pp 57–62

41.

Hayes RP, Baker DW (1998) Methodological problems in comparing English-speaking and Spanish-speaking patients’ satisfaction with interpersonal aspects of care. Med Care 36:230–236PubMedCrossRef

42.

Aday LA, Chiu GY, Andersen R (1980) Methodological issues in health care surveys of the Spanish heritage population. Am J Public Health 70:367PubMed

Titel: Symptoms after breast cancer treatment: are they influenced by patient characteristics?
verfasst von: Jean Yoon
Jennifer L. Malin
May Lin Tao
Diana M. Tisnado
John L. Adams
Martha J. Timmer
Patricia A. Ganz
Katherine L. Kahn
Publikationsdatum: 01.03.2008
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 2/2008
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-007-9599-3

Springer Medizin

Symptoms after breast cancer treatment: are they influenced by patient characteristics?

Abstract

Purpose

Methods

Results

Conclusion

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie