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01.05.2008 | Clinical Trial

No evidence of Human papillomavirus DNA sequences in invasive breast carcinoma

verfasst von: Patricia de Cremoux, Martine Thioux, Ingrid Lebigot, Brigitte Sigal-Zafrani, Rémy Salmon, Xavier Sastre-Garau, For the Institut Curie Breast Group

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 1/2008

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Abstract

Breast cancer is one of the most frequently diagnosed cancers in women in France, but its aetiology remains unknown. Viruses including Epstein-Barr virus (EBV), a human equivalent of murine mammary tumour virus (MMTV) and human papillomavirus (HPV) have been detected in benign breast tissues and breast tumours and are considered to be involved in the aetiology of breast cancer. The aim of this study was to determine the prevalence of high-risk oncogenic HPVs in breast carcinoma from French patients. Fifty unselected DNA samples extracted from invasive breast carcinoma tissues were analysed. Polymerase chain reaction (PCR) was performed to amplify both consensus GP5 + /GP6 + HPV sequences and specific sequences for HPV types 16, 18, 33, 45 and 6-11. No HPV-DNA sequences were detected in our series of 50 samples. These data argue against the role of oncogenic HPV in the pathogenesis of breast cancer.

Magrath I, Bhatia K (1999) Breast cancer: a new Epstein-Barr virus-associated disease? J Natl Cancer Inst 91:1349–1350PubMedCrossRef

Wong M, Pagano JS, Schiller JT, Tevethia SS, Raab-Traub N, Gruber J (2002) New associations of human papillomavirus, Simian virus 40, and Epstein-Barr virus with human cancer. J Natl Cancer Inst 94:1832–1836PubMed

Arbach H, Viglasky V, Lefeu F, Guinebretiere JM, Ramirez V, Bride N, Boualaga N, Bauchet T, Peyrat JP, Mathieu MC, Mourah S, Podgorniak MP, Seignerin JM, Takada K, Joab I (2006) Epstein-Barr virus (EBV) genome and expression in breast cancer tissue: effect of EBV infection of breast cancer cells on resistance to paclitaxel (Taxol). J Virol 80:845–853PubMedCrossRef

Wang Y, Pelisson I, Melana SM, Go V, Holland JF, Pogo BG (2001) MMTV-like env gene sequences in human breast cancer. Arch Virol 146:171–180PubMedCrossRef

Zammarchi F, Pistello M, Piersigilli A, Murr R, Di Cristofano C, Naccarato AG, Bevilacqua G (2006) MMTV-like sequences in human breast cancer: a fluorescent PCR/laser microdissection approach. J Pathol 209:436–444PubMedCrossRef

Zangen R, Harden S, Cohen D, Parrella P, Sidransky D (2002) Mouse mammary tumor-like env gene as a molecular marker for breast cancer? Int J Cancer 102:304–307PubMedCrossRef

Witt A, Hartmann B, Marton E, Zeillinger R, Schreiber M, Kubista E (2003) The mouse mammary tumor virus-like env gene sequence is not detectable in breast cancer tissue of Austrian patients. Oncol Rep 10:1025–1029PubMed

Kan CY, Iacopetta BJ, Lawson JS, Whitaker NJ (2005) Identification of human papillomavirus DNA gene sequences in human breast cancer. Br J Cancer 93:946–948PubMedCrossRef

Di Lonardo A, Venuti A, Marcante ML (1992) Human papillomavirus in breast cancer. Breast Cancer Res Treat 21:95–100PubMedCrossRef

10.

Hennig EM, Nesland JM, Di Lonardo A, Venuti A (1999) Multiple primary cancers and HPV infection: are they related? J Exp Clin Cancer Res 18:53–54PubMed

11.

Hennig EM, Suo Z, Thoresen S, Holm R, Kvinnsland S, Nesland JM (1999) Human papillomavirus 16 in breast cancer of women treated for high grade cervical intraepithelial neoplasia (CIN III). Breast Cancer Res Treat 53:121–135PubMedCrossRef

12.

Yu Y, Morimoto T, Sasa M, Okazaki K, Harada Y, Fujiwara T, Irie Y, Takahashi E, Tanigami A, Izumi K (2000) Human papillomavirus type 33 DNA in breast cancer in Chinese. Breast Cancer 7:33–36PubMedCrossRef

13.

Li T, Lu ZM, Guo M, Wu QJ, Chen KN, Xing HP, Mei Q, Ke Y (2002) p53 codon 72 polymorphism (C/G) and the risk of human papillomavirus-associated carcinomas in China. Cancer 95:2571–2576PubMedCrossRef

14.

de Villiers EM, Sandstrom RE, zur Hausen H, Buck CE (2005) Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast. Breast Cancer Res 7:R1–R11PubMedCrossRef

15.

Damin AP, Karam R, Zettler CG, Caleffi M, Alexandre CO (2004) Evidence for an association of human papillomavirus and breast carcinomas. Breast Cancer Res Treat 84:131–137PubMedCrossRef

16.

Wrede D, Luqmani YA, Coombes RC, Vousden KH (1992) Absence of HPV 16 and 18 DNA in breast cancer. Br J Cancer 65:891–894PubMed

17.

Gopalkrishna V, Singh UR, Sodhani P, Sharma JK, Hedau ST, Mandal AK, Das BC (1996) Absence of human papillomavirus DNA in breast cancer as revealed by polymerase chain reaction. Breast Cancer Res Treat 39:197–202PubMedCrossRef

18.

Bratthauer GL, Tavassoli FA, O’Leary TJ (1992) Etiology of breast carcinoma: no apparent role for papillomavirus types 6/11/16/18. Pathol Res Pract 188:384–386PubMed

19.

Ridolfi RL, Rosen PP, Port A, Kinne D, Mike V (1977) Medullary carcinoma of the breast: a clinicopathologic study with 10 year follow-up. Cancer 40:1365–1385PubMedCrossRef

20.

Lombard I, Vincent-Salomon A, Validire P, Zafrani B, de la Rochefordiere A, Clough K, Favre M, Pouillart P, Sastre-Garau X (1998) Human papillomavirus genotype as a major determinant of the course of cervical cancer. J Clin Oncol 16:2613–2619PubMed

21.

de Cremoux P, Thioux M, Peter M, Vielh P, Michon J, Delattre O, Magdelenat H (1997) Polymerase chain reaction compared with dot blotting for the determination of N-myc gene amplification in neuroblastoma. Int J Cancer 72:518–521PubMedCrossRef

22.

de Roda Husman AM, Walboomers JM, van den Brule AJ, Meijer CJ, Snijders PJ (1995) The use of general primers GP5 and GP6 elongated at their 3′ ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol 76(Pt 4):1057–1062PubMedCrossRef

23.

Kroupis C, Markou A, Vourlidis N, Dionyssiou-Asteriou A, Lianidou ES (2006) Presence of high-risk human papillomavirus sequences in breast cancer tissues and association with histopathological characteristics. Clin Biochem 39:727–731PubMed

24.

Widschwendter A, Brunhuber T, Wiedemair A, Mueller-Holzner E, Marth C (2004) Detection of human papillomavirus DNA in breast cancer of patients with cervical cancer history. J Clin Virol 31:292–297PubMedCrossRef

25.

Liu Y, Klimberg VS, Andrews NR, Hicks CR, Peng H, Chiriva-Internati M, Henry-Tillman R, Hermonat PL (2001) Human papillomavirus DNA is present in a subset of unselected breast cancers. J Hum Virol 4:329–334PubMed

Titel: No evidence of Human papillomavirus DNA sequences in invasive breast carcinoma
verfasst von: Patricia de Cremoux
Martine Thioux
Ingrid Lebigot
Brigitte Sigal-Zafrani
Rémy Salmon
Xavier Sastre-Garau
For the Institut Curie Breast Group
Publikationsdatum: 01.05.2008
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 1/2008
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-007-9626-4

Springer Medizin

No evidence of Human papillomavirus DNA sequences in invasive breast carcinoma

Abstract

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Springer Medizin

Abstract

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