nach oben

Breast Cancer Research and Treatment

Erschienen in:

01.06.2010 | Epidemiology

Meta-analysis of vitamin D, calcium and the prevention of breast cancer

verfasst von: Peizhan Chen, Pingting Hu, Dong Xie, Ying Qin, Fudi Wang, Hui Wang

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2010

Einloggen, um Zugang zu erhalten

Abstract

Vitamin D and calcium intake have been suggested to have protective effects against breast cancer; however, the data have been inconclusive. The present meta-analysis examined the overall effects of vitamin D intake, circulating 25(OH)D and 1α,25(OH)₂D levels, and calcium intake on breast cancer risk. Data from 11 studies on vitamin D intake, 7 studies on circulating 25(OH)D levels, 3 studies of circulating 1α,25(OH)₂D levels, and 15 studies on calcium intake and breast cancer risk were included in this analysis. From the meta-analysis, there was a significant inverse relationship between vitamin D intake and breast cancer risk, with an overall relative risk (RR) of high versus low vitamin D intake for breast cancer of 0.91 (95% CI = 0.85–0.97). The highest quantile of circulating 25(OH)D was found to be associated with a 45% (OR = 0.55, 95% CI = 0.38–0.80) decrease in breast cancer when compared with the lowest quantile. No significant association for the circulating 1α,25(OH)₂D level and breast cancer was found (OR = 0.99, 95% CI = 0.68–1.44). For calcium, a 19% (RR = 0.81, 95% CI = 0.72–0.90) decrease in breast cancer risk was found for those with highest quantile of calcium intake compared to the lowest quantile. These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.

Nur mit Berechtigung zugänglich

Garland CF, Garland FC, Gorham ED et al (2006) The role of vitamin D in cancer prevention. Am J Public Health 96:252–261. doi:10.2105/AJPH.2004.045260 CrossRefPubMed

Chen TC, Holick MF (2003) Vitamin D and prostate cancer prevention and treatment. Trends Endocrinol Metab 14:423–430. doi:10.1016/j.tem.2003.09.004 CrossRefPubMed

Cui Y, Rohan TE (2006) Vitamin D, calcium, and breast cancer risk: a review. Cancer Epidemiol Biomarkers Prev 15:1427–1437CrossRefPubMed

Wei MY, Garland CF, Gorham ED, Mohr SB, Giovannucci E (2008) Vitamin D and prevention of colorectal adenoma: a meta-analysis. Cancer Epidemiol Biomarkers Prev 17:2958–2969. doi:10.1158/1055-9965.EPI-08-0402 CrossRefPubMed

Bertone-Johnson ER (2009) Vitamin D and breast cancer. Ann Epidemiol 19:462–467. doi:10.1016/j.annepidem.2009.01.003 CrossRefPubMed

Garland FC, Garland CF, Gorham ED, Young JF (1990) Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prev Med 19:614–622CrossRefPubMed

Gorham ED, Garland FC, Garland CF (1990) Sunlight and breast cancer incidence in the USSR. Int J Epidemiol 19:820–824CrossRefPubMed

Grant WB (2002) An ecologic study of dietary and solar ultraviolet-B links to breast carcinoma mortality rates. Cancer 94:272–281. doi:10.1002/cncr.10196 CrossRefPubMed

Deeb KK, Trump DL, Johnson CS (2007) Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer 7:684–700. doi:10.1038/nrc2196 CrossRefPubMed

10.

Tang C, Chen N, Wu M, Yuan H, Du Y (2009) Fok1 polymorphism of vitamin D receptor gene contributes to breast cancer susceptibility: a meta-analysis. Breast Cancer Res Treat 117:391–399. doi:10.1007/s10549-008-0262-4 CrossRefPubMed

11.

Raimondi S, Johansson H, Maisonneuve P, Gandini S (2009) Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Carcinogenesis 30:1170–1180. doi:10.1093/carcin/bgp103 CrossRefPubMed

12.

Mathiasen IS, Sergeev IN, Bastholm L, Elling F, Norman AW, Jaattela M (2002) Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells. J Biol Chem 277:30738–30745CrossRefPubMed

13.

Sergeev IN (2004) Calcium as a mediator of 1,25-dihydroxyvitamin D3-induced apoptosis. J Steroid Biochem Mol Biol 89–90:419–425. doi:10.1016/j.jsbmb.2004.03.010 CrossRefPubMed

14.

Ishimi Y, Russell J, Sherwood LM (1990) Regulation by calcium and 1,25-(OH)2D3 of cell proliferation and function of bovine parathyroid cells in culture. J Bone Miner Res 5:755–760CrossRefPubMed

15.

Chopra DP, Sullivan JK, Reece-Kooyer S (1990) Regulation by calcium of proliferation and morphology of normal human tracheobronchial epithelial cell cultures. J Cell Sci 96:509–517PubMed

16.

Whitfield JF, Boynton AL, MacManus JP, Sikorska M, Tsang BK (1979) The regulation of cell proliferation by calcium and cyclic AMP. Mol Cell Biochem 27:155–179. doi:10.1007/BF00215364 CrossRefPubMed

17.

Xue L, Lipkin M, Newmark H, Wang J (1999) Influence of dietary calcium and vitamin D on diet-induced epithelial cell hyperproliferation in mice. J Natl Cancer Inst 91:176–181. doi:10.1093/jnci/91.2.176 CrossRefPubMed

18.

Jacobson EA, James KA, Newmark HL, Carroll KK (1989) Effects of dietary fat, calcium, and vitamin D on growth and mammary tumorigenesis induced by 7,12-dimethylbenz(a)anthracene in female Sprague-Dawley rats. Cancer Res 49:6300–6303PubMed

19.

Kesse-Guyot E, Bertrais S, Duperray B et al (2007) Dairy products, calcium and the risk of breast cancer: results of the French SU.VI.MAX prospective study. Ann Nutr Metab 51:139–145. doi:10.1159/000103274 CrossRefPubMed

20.

Knekt P, Jarvinen R, Seppanen R, Pukkala E, Aromaa A (1996) Intake of dairy products and the risk of breast cancer. Br J Cancer 73:687–691PubMed

21.

Landa MC, Frago N, Tres A (1994) Diet and the risk of breast cancer in Spain. Eur J Cancer Prev 3:313–320CrossRefPubMed

22.

Abbas S, Linseisen J, Chang-Claude J (2007) Dietary vitamin D and calcium intake and premenopausal breast cancer risk in a German case-control study. Nutr Cancer 59:54–61. doi:10.1080/01635580701390223 PubMed

23.

Shin MH, Holmes MD, Hankinson SE, Wu K, Colditz GA, Willett WC (2002) Intake of dairy products, calcium, and vitamin D and risk of breast cancer. J Natl Cancer Inst 94:1301–1311. doi:10.1093/jnci/94.17.1301 PubMed

24.

Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634PubMed

25.

Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L (2007) Performance of the trim and fill method in the presence of publication bias and between-study heterogeneity. Stat Med 26:4544–4562. doi:10.1002/sim.2889 CrossRefPubMed

26.

Duval S, Tweedie R (2000) Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56:455–463. doi:10.1111/j.0006-341X.2000.00455.x CrossRefPubMed

27.

Simard A, Vobecky J, Vobecky JS (1991) Vitamin D deficiency and cancer of the breast: an unprovocative ecological hypothesis. Can J Public Health 82:300–303PubMed

28.

Potischman N, Swanson CA, Coates RJ et al (1999) Intake of food groups and associated micronutrients in relation to risk of early-stage breast cancer. Int J Cancer 82:315–321. doi:10.1002/(SICI)1097-0215(19990730)82:3<315:AID-IJC1>3.0.CO;2-N CrossRefPubMed

29.

Levi F, Pasche C, Lucchini F, La Vecchia C (2001) Dietary intake of selected micronutrients and breast-cancer risk. Int J Cancer 91:260–263. doi:10.1002/1097-0215(200002)9999:9999<:AID-IJC1041>3.0.CO;2-# CrossRefPubMed

30.

Rossi M, McLaughlin JK, Lagiou P et al (2009) Vitamin D intake and breast cancer risk: a case-control study in Italy. Ann Oncol 20:374–378. doi:10.1093/annonc/mdn550 CrossRefPubMed

31.

John EM, Schwartz GG, Dreon DM, Koo J (1999) Vitamin D and breast cancer risk: the NHANES I Epidemiologic follow-up study, 1971–1975 to 1992. National Health and Nutrition Examination Survey. Cancer Epidemiol Biomarkers Prev 8:399–406PubMed

32.

Frazier AL, Li L, Cho E, Willett WC, Colditz GA (2004) Adolescent diet and risk of breast cancer. Cancer Causes Control 15:73–82. doi:10.1023/B:CACO.0000016617.57120.df CrossRefPubMed

33.

McCullough ML, Rodriguez C, Diver WR et al (2005) Dairy, calcium, and vitamin D intake and postmenopausal breast cancer risk in the Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev 14:2898–2904CrossRefPubMed

34.

Lin J, Manson JE, Lee IM, Cook NR, Buring JE, Zhang SM (2007) Intakes of calcium and vitamin D and breast cancer risk in women. Arch Intern Med 167:1050–1059CrossRefPubMed

35.

Robien K, Cutler GJ, Lazovich D (2007) Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women’s Health Study. Cancer Causes Control 18:775–782. doi:10.1007/s10552-007-9020-x CrossRefPubMed

36.

Lowe LC, Guy M, Mansi JL et al (2005) Plasma 25-hydroxy vitamin D concentrations, vitamin D receptor genotype and breast cancer risk in a UK Caucasian population. Eur J Cancer 41:1164–1169. doi:10.1016/j.ejca.2005.01.017 CrossRefPubMed

37.

Abbas S, Linseisen J, Slanger T et al (2008) Serum 25-hydroxyvitamin D and risk of post-menopausal breast cancer—results of a large case-control study. Carcinogenesis 29:93–99. doi:10.1093/carcin/bgm240 CrossRefPubMed

38.

Abbas S, Chang-Claude J, Linseisen J (2009) Plasma 25-hydroxyvitamin D and premenopausal breast cancer risk in a German case-control study. Int J Cancer 124:250–255. doi:10.1002/ijc.23904 CrossRefPubMed

39.

Crew KD, Gammon MD, Steck SE et al (2009) Association between plasma 25-hydroxyvitamin D and breast cancer risk. Cancer Prev Res 2:598–604. doi:10.1158/1940-6207.CAPR-08-0138 CrossRef

40.

Bertone-Johnson ER, Chen WY, Holick MF et al (2005) Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 14:1991–1997CrossRefPubMed

41.

Chlebowski RT, Johnson KC, Kooperberg C et al (2008) Calcium plus vitamin D supplementation and the risk of breast cancer. J Natl Cancer Inst 100:1581–1591. doi:10.1093/jnci/djn360 CrossRefPubMed

42.

Freedman DM, Chang SC, Falk RT et al (2008) Serum levels of vitamin D metabolites and breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev 17:889–894. doi:10.1158/1055-9965.EPI-07-2594 CrossRefPubMed

43.

Hiatt RA, Krieger N, Lobaugh B, Drezner MK, Vogelman JH, Orentreich N (1998) Prediagnostic serum vitamin D and breast cancer. J Natl Cancer Inst 90:461–463CrossRefPubMed

44.

Janowsky EC, Lester GE, Weinberg CR et al (1999) Association between low levels of 1,25-dihydroxyvitamin D and breast cancer risk. Public Health Nutr 2:283–291. doi:10.1017/S1368980099000385 CrossRefPubMed

45.

Larsson SC, Bergkvist L, Wolk A (2009) Long-term dietary calcium intake and breast cancer risk in a prospective cohort of women. Am J Clin Nutr 89:277–282. doi:10.3945/ajcn.2008.26704 CrossRefPubMed

46.

Boyapati SM, Shu XO, Jin F et al (2003) Dietary calcium intake and breast cancer risk among Chinese women in Shanghai. Nutr Cancer 46:38–43. doi:10.1207/S15327914NC4601_05 CrossRefPubMed

47.

Adzersen KH, Jess P, Freivogel KW, Gerhard I, Bastert G (2003) Raw and cooked vegetables, fruits, selected micronutrients, and breast cancer risk: a case-control study in Germany. Nutr Cancer 46:131–137. doi:10.1207/S15327914NC4602_05 CrossRefPubMed

48.

Negri E, La Vecchia C, Franceschi S et al (1996) Intake of selected micronutrients and the risk of breast cancer. Int J Cancer 65:140–144CrossRefPubMed

49.

Zaridze D, Lifanova Y, Maximovitch D, Day NE, Duffy SW (1991) Diet, alcohol consumption and reproductive factors in a case-control study of breast cancer in Moscow. Int J Cancer 48:493–501CrossRefPubMed

50.

Katsouyanni K, Willett W, Trichopoulos D et al (1988) Risk of breast cancer among Greek women in relation to nutrient intake. Cancer 61:181–185CrossRefPubMed

51.

Gissel T, Rejnmark L, Mosekilde L, Vestergaard P (2008) Intake of vitamin D and risk of breast cancer—a meta-analysis. J Steroid Biochem Mol Biol 111:195–199. doi:10.1016/j.jsbmb.2008.06.002 CrossRefPubMed

52.

Garland CF, Gorham ED, Mohr SB et al (2007) Vitamin D and prevention of breast cancer: pooled analysis. J Steroid Biochem Mol Biol 103:708–711. doi:10.1016/j.jsbmb.2006.12.007 CrossRefPubMed

53.

Pérez-López FR, Chedraui P, Haya J (2009) Vitamin D acquisition and breast cancer risk. Reprod Sci 16:7–19. doi:10.1177/1933719108327595 CrossRefPubMed

54.

Brisson J, Berube S, Diorio C, Sinotte M, Pollak M, Masse B (2007) Synchronized seasonal variations of mammographic breast density and plasma 25-hydroxyvitamin D. Cancer Epidemiol Biomarkers Prev 16:929–933. doi:10.1158/1055-9965.EPI-06-0746 CrossRefPubMed

55.

Berube S, Diorio C, Masse B et al (2005) Vitamin D and calcium intakes from food or supplements and mammographic breast density. Cancer Epidemiol Biomarkers Prev 14:1653–1659CrossRefPubMed

56.

Rohan TE, Negassa A, Chlebowski RT et al (2009) A randomized controlled trial of calcium plus vitamin D supplementation and risk of benign proliferative breast disease. Breast Cancer Res Treat 116:339–350. doi:10.1007/s10549-008-0213-0 CrossRefPubMed

Titel: Meta-analysis of vitamin D, calcium and the prevention of breast cancer
verfasst von: Peizhan Chen
Pingting Hu
Dong Xie
Ying Qin
Fudi Wang
Hui Wang
Publikationsdatum: 01.06.2010
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 2/2010
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-009-0593-9

Springer Medizin

Meta-analysis of vitamin D, calcium and the prevention of breast cancer

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2010

Three versus six months of exercise training in breast cancer survivors

Learning to predict relapse in invasive ductal carcinomas based on the subcellular localization of junctional proteins

XRCC3 Thr241Met polymorphism and breast cancer risk: a meta-analysis

E-cadherin polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer Study

The association of metabolic syndrome with triple-negative breast cancer

ICG fluorescence-guided sentinel node biopsy for axillary nodal staging in breast cancer

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie