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01.02.2009 | Original Paper

Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis

verfasst von: Katriina Heikkilä, Ross Harris, Gordon Lowe, Ann Rumley, John Yarnell, John Gallacher, Yoav Ben-Shlomo, Shah Ebrahim, Debbie A. Lawlor

Erschienen in: Cancer Causes & Control | Ausgabe 1/2009

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Abstract

Objective

We investigated the associations of circulating C-reactive protein (CRP) and interleukin-6 (IL-6) with cancer risk.

Methods

We examined the associations of CRP and IL-6 with incident cancer in two prospective cohorts, the British Women’s Heart and Health Study (4,286 women aged 60–80) and the Caerphilly Cohort (2,398 men aged 45–59) using Cox regression and pooled our findings with previous prospective studies’ in fixed and random effects meta-analyses.

Results

CRP and IL-6 were associated with some incident cancers in our cohorts, but the numbers of cancer cases were small. In our meta-analyses elevated CRP was associated with an increased overall risk of cancer (random effects estimate (RE): 1.10, 95% CI: 1.02, 1.18) and lung cancer (RE: 1.32, 95% CI: 1.08, 1.61). Its associations with colorectal (RE: 1.09, 95% CI: 0.98, 1.21) and breast cancer risks (RE: 1.10, 95% CI: 0.97, 1.26) were weaker. CRP appeared unrelated to prostate cancer risk (RE: 1.00 0.88, 1.13). IL-6 was associated with increased lung and breast cancer risks and decreased prostate cancer risk, and was unrelated to colorectal cancer risk.

Conclusions

Our findings suggest an etiological role for CRP and IL-6 in some cancers. Further large prospective and genetic studies would help to better understand this role.

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Titel: Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis
verfasst von: Katriina Heikkilä
Ross Harris
Gordon Lowe
Ann Rumley
John Yarnell
John Gallacher
Yoav Ben-Shlomo
Shah Ebrahim
Debbie A. Lawlor
Publikationsdatum: 01.02.2009
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 1/2009
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-008-9212-z

Springer Medizin

Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis