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01.08.2013 | Original paper

Dietary intake of B vitamins and methionine and breast cancer risk

verfasst von: Julie K. Bassett, Laura Baglietto, Allison M. Hodge, Gianluca Severi, John L. Hopper, Dallas R. English, Graham G. Giles

Erschienen in: Cancer Causes & Control | Ausgabe 8/2013

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Abstract

Purpose

We investigated prospectively the relationship between dietary intakes of methionine and B vitamins associated with one-carbon metabolism and breast cancer risk, including modification by age, hormone receptor status and alcohol consumption. Interactions between different B vitamins and methionine were also examined.

Methods

During follow-up of 20,756 women from the Melbourne Collaborative Cohort Study for an average of 16 years, we ascertained 936 incident breast cancers. Dietary intakes were estimated using a 121-item food frequency questionnaire. Hazard ratios (HR) and 95 % confidence intervals were estimated using Cox regression.

Results

We found weak evidence for an inverse association between breast cancer risk and riboflavin intake (fourth versus first quartile, HR_{Q4 vs. Q1} = 0.84 (0.69, 1.01); p _{linear trend} = 0.05) and a positive association for vitamin B12 (HR_{Q4 vs. Q1} = 1.21 (1.00, 1.46); p _{linear trend} = 0.06). We did not find any significant interactions between alcohol consumption and any of the B vitamins or methionine intake (all p _interaction > 0.17) or between methionine or folate intake and any other B vitamins (all p _interaction > 0.07). No association varied by tumor hormone receptor status (all p _homogeneity > 0.14).

Conclusions

We found weak evidence of an inverse association between breast cancer risk and riboflavin intake and a positive association with vitamin B12.

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Titel: Dietary intake of B vitamins and methionine and breast cancer risk
verfasst von: Julie K. Bassett
Laura Baglietto
Allison M. Hodge
Gianluca Severi
John L. Hopper
Dallas R. English
Graham G. Giles
Publikationsdatum: 01.08.2013
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 8/2013
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-013-0232-y

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Dietary intake of B vitamins and methionine and breast cancer risk

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Purpose

Methods

Results

Conclusions

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