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01.10.2013 | Original paper

The protective effect of coffee consumption on cutaneous melanoma risk and the role of GSTM1 and GSTT1 polymorphisms

verfasst von: Cristina Fortes, Simona Mastroeni, Paolo Boffetta, Gianluca Antonelli, Maria Antonietta Pilla, Giordano Bottà, Patrizia Anzidei, Federica Venanzetti

Erschienen in: Cancer Causes & Control | Ausgabe 10/2013

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Abstract

Purposes

The authors examined the association between coffee consumption and cutaneous melanoma and the implication of GSTM1 and GSTT1 polymorphisms.

Methods

A hospital-based case–control study was conducted in the inpatient wards of IDI-San Carlo Rome, Italy, including 304 incident cases of cutaneous melanoma and 305 controls. Information on socio-demographic characteristics, medical history, smoking, sun exposure, pigmentary characteristics and diet was collected for all subjects. Within the study, individual patterns at two polymorphic genes (GSTM1 and GSTT1) belonging to glutathione S-transferases family were investigated in 188 cases of cutaneous melanoma and 152 controls. Logistic regression was the method used to estimate odds ratio and 95 % confidence intervals.

Results

High frequency of coffee drinking (>once daily), compared with low-frequency consumption of coffee (≤7 times weekly) was associated with a protective effect for cutaneous melanoma (OR 0.46; 95 % CI 0.31–0.68) after adjusting for sex, age, education, hair colour, common nevi, skin phototype, and sunburn episodes in childhood. When stratified by GSTM1 and GSTT1 genotype, the protective effect of coffee was extremely high for subjects with both GSTM1 and GSTT1 null polymorphisms (OR 0.01; 95 % CI 0.0003–0.54).

Conclusions

Our results show a protective effect of coffee consumption for cutaneous melanoma, in particular for those with homozygous deletion for GSTM1 and GSTT1.

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Titel: The protective effect of coffee consumption on cutaneous melanoma risk and the role of GSTM1 and GSTT1 polymorphisms
verfasst von: Cristina Fortes
Simona Mastroeni
Paolo Boffetta
Gianluca Antonelli
Maria Antonietta Pilla
Giordano Bottà
Patrizia Anzidei
Federica Venanzetti
Publikationsdatum: 01.10.2013
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 10/2013
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-013-0255-4

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The protective effect of coffee consumption on cutaneous melanoma risk and the role of GSTM1 and GSTT1 polymorphisms