Skip to main content
Erschienen in: Cancer Causes & Control 4/2017

28.02.2017 | Original paper

Physical activity and lung cancer risk in men and women

verfasst von: Vikki Ho, Marie-Elise Parent, Javier Pintos, Michal Abrahamowicz, Coraline Danieli, Lesley Richardson, Robert Bourbonnais, Lise Gauvin, Jack Siemiatycki, Anita Koushik

Erschienen in: Cancer Causes & Control | Ausgabe 4/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Although evidence has accumulated that recreational physical activities (PA) may reduce lung cancer risk, there is little evidence concerning the possible role of a potentially more important source of PA, namely occupational PA. We investigated both recreational and lifetime occupational PA in relation to lung cancer risk in a population-based case–control study in Montreal, Canada (NCASES = 727; NCONTROLS = 1,351).

Methods

Unconditional logistic regression was used to estimate odds ratios (OR), separately for men and women, adjusting for smoking, exposure to occupational carcinogens, and sociodemographic and lifestyle factors.

Results

In both sexes, increasing recreational PA was associated with a lower lung cancer risk (ORMEN = 0.66, 95% confidence interval (CI) 0.47–0.92; ORWOMEN = 0.55, 95% CI 0.34–0.88, comparing the highest versus lowest tertiles). For occupational PA, no association was observed among women, while increasing occupational PA was associated with increased risk among men (ORMEN = 1.96, 95% CI 1.27–3.01). ORs were not modified by occupational lung carcinogen exposure, body mass index, and smoking level; results were similar across lung cancer histological types.

Conclusions

Our results support the previous findings for recreational PA and lung cancer risk. Unexpectedly, our findings suggest a positive association for occupational PA; this requires replication and more detailed investigation.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Parkin DM, Sasco AJ (1993) Lung cancer: worldwide variation in occurrence and proportion attributable to tobacco use. Lung Cancer 9:1–16CrossRef Parkin DM, Sasco AJ (1993) Lung cancer: worldwide variation in occurrence and proportion attributable to tobacco use. Lung Cancer 9:1–16CrossRef
2.
Zurück zum Zitat Abraham J, Gulley JL, Allegra CJ (2005) Bethesda handbook of clinical oncology. Lippincott Williams & Wilkins, Philadelphia Abraham J, Gulley JL, Allegra CJ (2005) Bethesda handbook of clinical oncology. Lippincott Williams & Wilkins, Philadelphia
3.
Zurück zum Zitat Friedenreich CM, MR Orenstein, (2002) Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr 132(11 Suppl):3456S-3464SPubMed Friedenreich CM, MR Orenstein, (2002) Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr 132(11 Suppl):3456S-3464SPubMed
4.
Zurück zum Zitat Lee IM (2003) Physical activity and cancer prevention–data from epidemiologic studies. Med Sci Sports Exerc 35(11):1823–1827CrossRefPubMed Lee IM (2003) Physical activity and cancer prevention–data from epidemiologic studies. Med Sci Sports Exerc 35(11):1823–1827CrossRefPubMed
5.
Zurück zum Zitat Kruk J, Aboul-Enein HY (2006) Physical activity in the prevention of cancer. Asian Pac J Cancer Prev 7(1):11–21PubMed Kruk J, Aboul-Enein HY (2006) Physical activity in the prevention of cancer. Asian Pac J Cancer Prev 7(1):11–21PubMed
6.
Zurück zum Zitat Brenner DR et al (2016) Leisure-time physical activity and lung cancer risk: A systematic review and meta-analysis. Lung Cancer 95:17–27CrossRefPubMed Brenner DR et al (2016) Leisure-time physical activity and lung cancer risk: A systematic review and meta-analysis. Lung Cancer 95:17–27CrossRefPubMed
7.
Zurück zum Zitat Quadrilatero J, Hoffman-Goetz L (2003) Physical activity and colon cancer. A systematic review of potential mechanisms. J Sports Med Phys Fit 43(2):121–138 Quadrilatero J, Hoffman-Goetz L (2003) Physical activity and colon cancer. A systematic review of potential mechanisms. J Sports Med Phys Fit 43(2):121–138
8.
Zurück zum Zitat Csizmadi I et al (2011) Hours spent and energy expended in physical activity domains: results from the tomorrow project cohort in Alberta, Canada. Int J Behav Nutr Phys Act 8:110CrossRefPubMedPubMedCentral Csizmadi I et al (2011) Hours spent and energy expended in physical activity domains: results from the tomorrow project cohort in Alberta, Canada. Int J Behav Nutr Phys Act 8:110CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Steindorf K et al (2006) Physical activity and lung cancer risk in the European prospective investigation into cancer and nutrition cohort. Int J Cancer 119(10):2389–2397CrossRefPubMed Steindorf K et al (2006) Physical activity and lung cancer risk in the European prospective investigation into cancer and nutrition cohort. Int J Cancer 119(10):2389–2397CrossRefPubMed
10.
Zurück zum Zitat Rundle A et al (2010) Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC. Biomarkers 15(1):20–30CrossRefPubMedPubMedCentral Rundle A et al (2010) Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC. Biomarkers 15(1):20–30CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Bak H et al (2005) Physical activity and risk for lung cancer in a Danish cohort. Int J Cancer 116(3):439–445CrossRefPubMed Bak H et al (2005) Physical activity and risk for lung cancer in a Danish cohort. Int J Cancer 116(3):439–445CrossRefPubMed
12.
Zurück zum Zitat Colbert LH et al (2002) Physical activity and lung cancer risk in male smokers. Int J Cancer 98(5):770–773CrossRefPubMed Colbert LH et al (2002) Physical activity and lung cancer risk in male smokers. Int J Cancer 98(5):770–773CrossRefPubMed
13.
Zurück zum Zitat Severson RK et al (1989) A prospective analysis of physical activity and cancer. Am J Epidemiol 130(3):522–529CrossRefPubMed Severson RK et al (1989) A prospective analysis of physical activity and cancer. Am J Epidemiol 130(3):522–529CrossRefPubMed
14.
Zurück zum Zitat Thune I, Lund E (1997) The influence of physical activity on lung-cancer risk: a prospective study of 81,516 men and women. Int J Cancer 70(1):57–62CrossRefPubMed Thune I, Lund E (1997) The influence of physical activity on lung-cancer risk: a prospective study of 81,516 men and women. Int J Cancer 70(1):57–62CrossRefPubMed
16.
Zurück zum Zitat Dosemeci M et al (1993) Occupational physical activity, socioeconomic status, and risks of 15 cancer sites in Turkey. Cancer Causes Control 4(4):313–321CrossRefPubMed Dosemeci M et al (1993) Occupational physical activity, socioeconomic status, and risks of 15 cancer sites in Turkey. Cancer Causes Control 4(4):313–321CrossRefPubMed
17.
Zurück zum Zitat Parent ME et al (2011) Occupational and recreational physical activity during adult life and the risk of cancer among men. Cancer Epidemiol 35(2):151–159CrossRefPubMed Parent ME et al (2011) Occupational and recreational physical activity during adult life and the risk of cancer among men. Cancer Epidemiol 35(2):151–159CrossRefPubMed
18.
Zurück zum Zitat Leitzmann MF et al (2009) Prospective study of physical activity and lung cancer by histologic type in current, former, and never smokers. Am J Epidemiol. doi:10.1093/aje/kwn371 Leitzmann MF et al (2009) Prospective study of physical activity and lung cancer by histologic type in current, former, and never smokers. Am J Epidemiol. doi:10.​1093/​aje/​kwn371
19.
Zurück zum Zitat Steenland K, Nowlin S, Palu S (1995) Cancer incidence in the National Health and Nutrition Survey I. Follow-up data: diabetes, cholesterol, pulse and physical activity. Cancer Epidemiol Biomark Prev 4(8):807–811 Steenland K, Nowlin S, Palu S (1995) Cancer incidence in the National Health and Nutrition Survey I. Follow-up data: diabetes, cholesterol, pulse and physical activity. Cancer Epidemiol Biomark Prev 4(8):807–811
20.
21.
Zurück zum Zitat Parent ME et al (2007) Exposure to diesel and gasoline engine emissions and the risk of lung cancer. Am J Epidemiol 165(1):53–62CrossRefPubMed Parent ME et al (2007) Exposure to diesel and gasoline engine emissions and the risk of lung cancer. Am J Epidemiol 165(1):53–62CrossRefPubMed
23.
Zurück zum Zitat Ainsworth BE et al (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32(9 Suppl):S498–S504CrossRefPubMed Ainsworth BE et al (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32(9 Suppl):S498–S504CrossRefPubMed
24.
Zurück zum Zitat Anshell M, Freedson P, Haywood K (1991) Dictionary of the sports and exercise sciences, ed. H.K. Books, Champaign Anshell M, Freedson P, Haywood K (1991) Dictionary of the sports and exercise sciences, ed. H.K. Books, Champaign
25.
Zurück zum Zitat Leffondre K et al (2006) Modelling smoking history using a comprehensive smoking index: application to lung cancer. Stat Med 25(24):4132–4146CrossRefPubMed Leffondre K et al (2006) Modelling smoking history using a comprehensive smoking index: application to lung cancer. Stat Med 25(24):4132–4146CrossRefPubMed
27.
Zurück zum Zitat Evans D et al (2012) Combining directed acyclic graphs and the change-in-estimate procedure as a novel approach to adjustment-variable selection in epidemiology. BMC Med Res Methodol 12:156CrossRefPubMedPubMedCentral Evans D et al (2012) Combining directed acyclic graphs and the change-in-estimate procedure as a novel approach to adjustment-variable selection in epidemiology. BMC Med Res Methodol 12:156CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Royston P, Sauerbrie W (2008) Multivariable model—building: a pragmatic approach to regression analysis based on fractional polynomials for modelling continuous variables. John Wiley & Sons, West SussexCrossRef Royston P, Sauerbrie W (2008) Multivariable model—building: a pragmatic approach to regression analysis based on fractional polynomials for modelling continuous variables. John Wiley & Sons, West SussexCrossRef
29.
Zurück zum Zitat Royston P, Altman DG (1994) Regression using fractional polynomials of continuous covariates: parsimonious parametric modelling. J Royal Stat Soc 43(3):429–467 Royston P, Altman DG (1994) Regression using fractional polynomials of continuous covariates: parsimonious parametric modelling. J Royal Stat Soc 43(3):429–467
30.
Zurück zum Zitat WHO (1995) Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee, WHO Technical Report Series 854. World Health Organization, Geneva WHO (1995) Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee, WHO Technical Report Series 854. World Health Organization, Geneva
31.
Zurück zum Zitat Kubik A et al (2008) A case–control study of lifestyle and lung cancer associations by histological types. Neoplasma 55(3):192–199PubMed Kubik A et al (2008) A case–control study of lifestyle and lung cancer associations by histological types. Neoplasma 55(3):192–199PubMed
32.
Zurück zum Zitat Mao Y et al (2003) Physical activity and the risk of lung cancer in Canada. Am J Epidemiol 158(6):564–575CrossRefPubMed Mao Y et al (2003) Physical activity and the risk of lung cancer in Canada. Am J Epidemiol 158(6):564–575CrossRefPubMed
33.
Zurück zum Zitat Sinner P et al (2006) The association of physical activity with lung cancer incidence in a cohort of older women: the Iowa Women’s Health Study. Cancer Epidemiol Biomark Prev 15(12):2359–2363CrossRef Sinner P et al (2006) The association of physical activity with lung cancer incidence in a cohort of older women: the Iowa Women’s Health Study. Cancer Epidemiol Biomark Prev 15(12):2359–2363CrossRef
34.
Zurück zum Zitat Kukkonen-Harjula K (2007) Physical activity and cardiovascular health—work and leisure differ. Scandinavian J Work Environ Health 33(6):401–404CrossRef Kukkonen-Harjula K (2007) Physical activity and cardiovascular health—work and leisure differ. Scandinavian J Work Environ Health 33(6):401–404CrossRef
35.
Zurück zum Zitat Karlqvist L, Leijon O, Harenstam A (2003) Physical demands in working life and individual physical capacity. Eur J Appl Physiol 89(6):536–547CrossRefPubMed Karlqvist L, Leijon O, Harenstam A (2003) Physical demands in working life and individual physical capacity. Eur J Appl Physiol 89(6):536–547CrossRefPubMed
37.
Zurück zum Zitat Pedersen BK, Rohde T, Ostrowski K (1998) Recovery of the immune system after exercise. Acta Physiol Scand 162(3):325–332CrossRefPubMed Pedersen BK, Rohde T, Ostrowski K (1998) Recovery of the immune system after exercise. Acta Physiol Scand 162(3):325–332CrossRefPubMed
39.
Zurück zum Zitat Schottenfeld DJF Fraumeni (2006) Cancer epidemiology and prevention 3rd ed. Oxford University Press, New YorkCrossRef Schottenfeld DJF Fraumeni (2006) Cancer epidemiology and prevention 3rd ed. Oxford University Press, New YorkCrossRef
40.
Zurück zum Zitat Shephard RJ, Shek PN (1998) Associations between physical activity and susceptibility to cancer: possible mechanisms. Sports Med 26(5):293–315CrossRefPubMed Shephard RJ, Shek PN (1998) Associations between physical activity and susceptibility to cancer: possible mechanisms. Sports Med 26(5):293–315CrossRefPubMed
41.
Zurück zum Zitat Steindorf K et al (2005) Case–control study of lifetime occupational and recreational physical activity and risks of colon and rectal cancer. Eur J Cancer Prev 14(4):363–371CrossRefPubMed Steindorf K et al (2005) Case–control study of lifetime occupational and recreational physical activity and risks of colon and rectal cancer. Eur J Cancer Prev 14(4):363–371CrossRefPubMed
42.
Zurück zum Zitat Friedenreich CM, Courneya KS, Bryant HE (2001) Influence of physical activity in different age and life periods on the risk of breast cancer. Epidemiology 12(6):604–612CrossRefPubMed Friedenreich CM, Courneya KS, Bryant HE (2001) Influence of physical activity in different age and life periods on the risk of breast cancer. Epidemiology 12(6):604–612CrossRefPubMed
Metadaten
Titel
Physical activity and lung cancer risk in men and women
verfasst von
Vikki Ho
Marie-Elise Parent
Javier Pintos
Michal Abrahamowicz
Coraline Danieli
Lesley Richardson
Robert Bourbonnais
Lise Gauvin
Jack Siemiatycki
Anita Koushik
Publikationsdatum
28.02.2017
Verlag
Springer International Publishing
Erschienen in
Cancer Causes & Control / Ausgabe 4/2017
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-017-0872-4

Weitere Artikel der Ausgabe 4/2017

Cancer Causes & Control 4/2017 Zur Ausgabe

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

25.04.2024 NSCLC Nachrichten

Das Risiko für Rezidiv oder Tod von Patienten und Patientinnen mit reseziertem ALK-positivem NSCLC ist unter einer adjuvanten Therapie mit dem Tyrosinkinase-Inhibitor Alectinib signifikant geringer als unter platinbasierter Chemotherapie.

Bei Senioren mit Prostatakarzinom auf Anämie achten!

24.04.2024 DGIM 2024 Nachrichten

Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.

ICI-Therapie in der Schwangerschaft wird gut toleriert

Müssen sich Schwangere einer Krebstherapie unterziehen, rufen Immuncheckpointinhibitoren offenbar nicht mehr unerwünschte Wirkungen hervor als andere Mittel gegen Krebs.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.