nach oben

The International Journal of Cardiovascular Imaging

Erschienen in:

01.02.2008 | Original paper

Obesity is associated with aortic enlargement and increased stiffness: an echocardiographic study

verfasst von: Attila Nemes, Henriette Gavallér, Éva Csajbók, Tamás Forster, Miklós Csanády

Erschienen in: The International Journal of Cardiovascular Imaging | Ausgabe 2/2008

Einloggen, um Zugang zu erhalten

Abstract

Background

Obesity may be associated with early vascular changes. The current study was designed to assess the relationship between obesity and aortic stiffness in two populations, one aged 18–40 years and one aged 41–64 years.

Methods

The study complied 121 subjects, all of them underwent a physical examination, transthoracic echocardiography and blood pressure measurement. Aortic stiffness index (β) was evaluated from aortic diameter and blood pressure data.

Results

β was higher in obese subjects both in the young (4.26 ± 1.57 vs. 6.88 ± 5.96, P < 0.05) and old patient populations (7.13 ± 4.99 vs. 14.89 ± 14.64, P < 0.05). Systolic (SD) aortic diameters (in mm) were enlarged in obese young patients (25.7 ± 2.8 vs. 27.1 ± 2.5, P < 0.05) and obese old subjects (28.0 ± 3.0 vs. 30.3 ± 3.3, P < 0.05). Diastolic (DD) aortic diameter (in mm) showed similar tendency in youngs (22.8 ± 2.9 vs. 24.9 ± 2.5, P < 0.05) and old subjects (25.9 ± 2.7 vs. 28.0 ± 3.1, P < 0.05).

Conclusions

Aortic stiffness is higher in young obese patients and similar to older subjects without obesity. Both SD and DD are increasing with age, but subjects within similar age group have larger SD and DD suggesting early vascular remodelling in obesity.

Kurth T, Gaziano JM, Berger K et al (2002) Body mass index and the risk of stroke in men. Arch Intern Med 162:2557–2562PubMedCrossRef

Wilson PW, D’Agostino RB, Sullivan L et al (2002) Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med 162:1867–1872PubMedCrossRef

Sutton-Tyrrell K, Newman A, Simonsick EM et al (2001) Aortic stiffness is associated with visceral adiposity in older adults enrolled in the study of health, aging, and body composition. Hypertension 38:429–433PubMed

Stefanadis C, Stratos C, Boudoulas H, Kourouklis C, Toutouzas P (1990) Distensibility of the ascending aorta: comparison of invasive and non-invasive techniques in healthy men and in men with coronary artery disease. Eur Heart J 11:990–996PubMed

Nemes A, Caliskan K, Geleijnse ML et al (2007) Alterations in aortic elasticity in noncompaction cardiomyopathy. Int J Cardiovasc Imag (in press)

WHO. (1998) Obesity: preventing and managing the global epidemic: report of a WHO consultation of obesity, Geneva, 1997, World Health Organisation. Obes Res 6:51S–210S

Lakka HM, Laaksonen DE, Lakka TA et al (2002) The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 288:2709–2716PubMedCrossRef

Nemes A, Galema TW, Geleijnse ML et al (2007) Aortic valve replacement for aortic stenosis is associated with improved aortic distensibility at long-term follow-up. Am Heart J 153:147–151PubMedCrossRef

Henry WL, DeMaria A, Gramiak R et al (1980) Report of the American Society of Echocardiography Committee on Nomenclature and Standards in Two-dimensional Echocardiography. Circulation 62:212–217PubMed

10.

Pannier B, Guerin AP, Marchais SJ et al (2005) Stiffness of capacitive and conduit arteries: prognostic significance for end-stage renal disease patients. Hypertension 45:592–596PubMedCrossRef

11.

Blacher J, Safar ME, Pannier B et al (2002) Prognostic significance of arterial stiffness measurements in end-stage renal disease patients. Curr Opin Nephrol Hypertens 11:629–634PubMedCrossRef

12.

Nemes A, Forster T, Csanady M, (2007) Impaired coronary flow velocity reserve and aortic distensibility in patients with untreated hypercholesterolemia—an echocardiographic study. Int J Cardiovasc Imaging 23:15–23PubMedCrossRef

13.

Nemes A, Forster T, Csanady M et al (2004) Indices of aortic distensibility and coronary flow velocity reserve in patients with different grades of aortic atherosclerosis. Int J Cardiovasc Imaging 20:271–277PubMedCrossRef

14.

Danias PG, Tritos NA, Stuber M et al (2003) Comparison of aortic elasticity determined by cardiovascular magnetic resonance imaging in obese versus lean adults. Am J Cardiol 91:195–199PubMedCrossRef

15.

Wildman RP, Mackey RH, Bostom A et al (2003) Measures of obesity are associated with vascular stiffness in young and older adults. Hypertension 42:468–473PubMedCrossRef

16.

Mackey RH, Sutton-Tyrrell K, Vaitkevicius PV et al (2002) Correlates of aortic stiffness in elderly individuals: a subgroup of the Cardiovascular Health Study. Am J Hypertens 15:16–23PubMedCrossRef

17.

Wildman RP, Farhat GN, Patel AS et al (2005) Weight change is associated with change in arterial stiffness among healthy young adults. Hypertension 45:187–192PubMedCrossRef

18.

Brunzell JD, Hokanson JE (1999) Dyslipidemia of central obesity and insulin resistance. Diabetes Care 22(Suppl 3):C10–C13PubMed

19.

Stenvinkel P, Bolinder J, Alvestrand A (1992) Effects of insulin on renal haemodynamics and the proximal and distal tubular sodium handling in healthy subjects. Diabetologia 35:1042–1048PubMedCrossRef

20.

Young JB (1988) Effect of experimental hyperinsulinemia on sympathetic nervous system activity in the rat. Life Sci 43:193–200PubMedCrossRef

21.

Ulrich P, Cerami A (2001) Protein glycation, diabetes, and aging. Recent Prog Horm Res 56:1–21PubMedCrossRef

22.

DeFronzo RA, Ferrannini E. (1991) Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173–194PubMedCrossRef

23.

Kahn BB, Flier JS (2000) Obesity and insulin resistance. J Clin Invest 106:473–481PubMedCrossRef

24.

Arcaro G, Cretti A, Balzano S et al (2002) Insulin causes endothelial dysfunction in humans: sites and mechanisms. Circulation 105:576–582PubMedCrossRef

25.

Egan BM, Lu G, Greene EL (1999) Vascular effects of non-esterified fatty acids: implications for the cardiovascular risk factor cluster. Prostaglandins Leukot Essent Fatty Acids 60:411–420PubMedCrossRef

26.

Weyer C, Yudkin JS, Stehouwer CD et al (2002) Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians. Atherosclerosis 161:233–242PubMedCrossRef

27.

Visser M, Bouter LM, McQuillan GM et al (1999) Elevated C-reactive protein levels in overweight and obese adults. JAMA 282:2131–2135PubMedCrossRef

28.

Schutte R, Huisman HW, Schutte AE et al (2005) Leptin is independently associated with systolic blood pressure, pulse pressure and arterial compliance in hypertensive African women with increased adiposity: the POWIRS study. J Hum Hypertens 19:535–541PubMedCrossRef

Titel: Obesity is associated with aortic enlargement and increased stiffness: an echocardiographic study
verfasst von: Attila Nemes
Henriette Gavallér
Éva Csajbók
Tamás Forster
Miklós Csanády
Publikationsdatum: 01.02.2008
Verlag: Springer Netherlands
Erschienen in: The International Journal of Cardiovascular Imaging / Ausgabe 2/2008
Print ISSN: 1569-5794
Elektronische ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-007-9248-2

Neu im Fachgebiet Kardiologie

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

26.04.2024 Mammografie Nachrichten

Routinemäßige Mammografien helfen, Brustkrebs frühzeitig zu erkennen. Anhand der Röntgenuntersuchung lassen sich aber auch kardiovaskuläre Risikopatientinnen identifizieren. Als zuverlässiger Anhaltspunkt gilt die Verkalkung der Brustarterien.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Adipositas-Medikament auch gegen Schlafapnoe wirksam

24.04.2024 Adipositas Nachrichten

Der als Antidiabetikum sowie zum Gewichtsmanagement zugelassene Wirkstoff Tirzepatid hat in Studien bei adipösen Patienten auch schlafbezogene Atmungsstörungen deutlich reduziert, informiert der Hersteller in einer Vorab-Meldung zum Studienausgang.

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2008

Diagnostic tools in the preoperative evaluation of children with anomalous pulmonary venous connections

Comparison of intravascular ultrasonic imaging with versus without incomplete stent apposition at follow-up after drug-eluting stent implantation

What is the best myocardial perfusion protocol in diabetic patients?

Adenosine stress first pass perfusion for the detection of coronary artery disease in patients with aortic stenosis: a feasibility study

Focal macroscopic fat deposition within the right ventricular wall in asymptomatic patients undergoing screening EBCT coronary calcium scoring examinations