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Cancer and Metastasis Reviews
Erschienen in: Cancer and Metastasis Reviews 1-2/2009

01.06.2009

Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility

verfasst von: T. Y. Kim, D. Vigil, C. J. Der, R. L. Juliano

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 1-2/2009

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Abstract

DLC-1 was originally identified as a potential tumor suppressor. One of the key biochemical functions of DLC-1 is to serve as a GTPase activating protein (GAP) for members of the Rho family of GTPases, particularly Rho A-C and Cdc 42. Since these GTPases are critically involved in regulation of the cytoskeleton and cell migration, it seems clear that DLC-1 will also influence these processes. In this review we examine basic aspects of the actin cyoskeleton and how it relates to cell motility. We then delineate the characteristics of DLC-1 and other members of its family, and describe how they may have multiple effects on the regulation of cell polarity, actin organization, and cell migration.
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Metadaten
Titel
Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility
verfasst von
T. Y. Kim
D. Vigil
C. J. Der
R. L. Juliano
Publikationsdatum
01.06.2009
Verlag
Springer US
Erschienen in
Cancer and Metastasis Reviews / Ausgabe 1-2/2009
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-008-9167-2

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