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Cancer and Metastasis Reviews

Erschienen in:

01.12.2011

Autotaxin and LPA receptor signaling in cancer

verfasst von: Anna J. S. Houben, Wouter H. Moolenaar

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 3-4/2011

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Abstract

Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) is a lipid mediator that functions as a mitogen and motility factor for many cell types. LPA signals through six specific G protein-coupled receptors, named LPA_1–6, which trigger both overlapping and distinct signaling pathways. LPA is produced from extracellular lysophosphatidylcholine by a secreted lysophospholipase D, named autotaxin (ATX), originally identified as an “autocrine motility factor” for tumor cells. ATX–LPA signaling is vital for embryonic development and promotes tumor formation, angiogenesis, and experimental metastasis in mice. Elevated expression of ATX and/or aberrant expression of LPA receptors are found in several human malignancies, while loss of LPA₆ function has been implicated in bladder cancer. In this review, we summarize our present understanding of ATX and LPA receptor signaling in cancer.

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Titel: Autotaxin and LPA receptor signaling in cancer
verfasst von: Anna J. S. Houben
Wouter H. Moolenaar
Publikationsdatum: 01.12.2011
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 3-4/2011
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-011-9319-7

Springer Medizin

Autotaxin and LPA receptor signaling in cancer

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