nach oben

Erschienen in:

01.10.2006 | Original Paper

Usefulness of Serum Pepsinogens in Helicobacter pylori Chronic Gastritis: Relationship With Inflammation, Activity, and Density of the Bacterium

verfasst von: Francesco Di Mario, Lucas Giovanni Cavallaro, Ali Mahamat Moussa, Pietro Caruana, Roberta Merli, Andrea Maini, Simone Bertolini, Nadia Dal Bó, Massimo Rugge, Giulia Martina Cavestro, Giovanni Aragona, Mario Plebani, Angelo Franzé, Giorgio Nervi

Erschienen in: Digestive Diseases and Sciences | Ausgabe 10/2006

Einloggen, um Zugang zu erhalten

Abstract

We sought to study the relationship between serum pepsinogens and different histopathologic features of Helicobacter pylori-related chronic gastritis. One hundred forty-nine consecutive dyspeptic patients underwent endoscopy with biopsies; serum pepsinogens I and II were measured by immunoassay. Serum levels of pepsinogens (sPG) were significantly correlated with H. pylori density both of the corpus (sPGI: r = 0.32, P < .001; sPGII: r = 0.56, P < .001) and antrum (sPGI: r = 0.41, P < .001; sPGII: r = 0.43, P < .001) as well as with chronic inflammation (sPGI: r = 0.26, P < .001; sPGII: r = 0.49, P < .001) and activity (sPGI: r = 0.38, P < .001; sPGII: r = 0.50, P < .001) in the antrum. Only sPGII was correlated with chronic inflammation (r = 0.44, P < .001) and activity (r = 0.40, P < .001) in the corpus. SPGI was inversely correlated with atrophy (r = –0.33, P < .001) and intestinal metaplasia (r = –0.37, P < .001) in the corpus. sPGII levels could be considered as markers of gastric inflammation all over in the stomach. sPGI levels are inversely related to atrophic body gastritis.

Kudo M, Asaka M, Kato M, Katagiri M, Kagaya H, Nishikawa K, Koshiyama T, Hokari K, Meguro T, Takeda H, Yoshida J, Inoue K (1995) Role of Helicobacter pylori in chronic gastritis: a prospective study. J Clin Gastroenterol 2(Suppl 1):S174–S178

Yoshida N, Granger DN, Evans DJ Jr, Graham DY, Anderson DC, Wolf RE, Kvietys PR (1993) Mechanisms involved in Helicobacter pylori-induced inflammation. Gastroenterology 105:1431–1440PubMed

Rugge M, Correa P, Dixon MF, Fiocca R, Hattori T, Lechago J, Leandro G, Price AB, Sipponen P, Solcia E, Watabe H, Genta RM (2002) Gastric mucosal atrophy: interobserver consistency using new criteria for classification and grading. Aliment Pharmacol Ther 16:1249–1259PubMedCrossRef

Marshall BJ, Goodwin CS, Warren JR, Murray R, Blincow ED, Blackbourn SJ (1998) Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet 2:1437–1442

Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamagushi S, Yamakido M, Taniyama K, Sasaki N, Schlemper RJ (2001) Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 345:784–789PubMedCrossRef

Parsonnet J, Hansen S, Rodriguez L, Gelb AB, Warnke RA, Jellum E, Orentreich N, Vogelman JH, Friedman GD (1994) Helicobacter pylori infection and gastric lymphoma. N Engl J Med 330:1267–1271PubMedCrossRef

Carpenter HA, Talley N (1995) Gastroscopy is incomplete without biopsy: clinical relevance of distinguishing gastropathy from gastritis. Gastroenterology 108:917–924PubMedCrossRef

Samloff MI, Varis K, Ihamaki T, Siurala M, Rotter IJ (1982) Relationship among serum pepsinogen I, serum pepsinogen II and gastric mucosal histology. A study of relatives of patients with pernicious anemia. Gastroenterology 83:204–209

Di Mario F, Vianello F, Plebani M (1985) Peptic secretion, clinical and pathophysiological features. Padova, Piccin

10.

Westerveld BD, Pals G, Lamers CB, Defize J, Pronk JC, Frants RR, Ooms EC, Kreuning J, Kostanse PJ, Eriksson AW, et al (1987) Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels. Cancer 59:952–958PubMedCrossRef

11.

Kekki M, Samloff IM, Varis K, Ihamàki T (1991) Serum pepsinogens and serum gastrin in screening of severe atrophic corpus gastritis. Scand J Gastroenterol 186:109–116

12.

Wagner S, Haruma K, Gladziwa U, Soudah B, Gebel M, Bleck J, Schmidt H, Manns M (1994) Helicobacter pylori infection and serum pepsinogen A, pepsinogen A, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication. Am J Gastroenterol 89:211–218

13.

Kekki M, Samloff IM, Varis K, Ihamaki T (1991) Serum pepsinogen I and serum gastrin in the screening of severe atrophic corpus gastritis. Scand J Gastroenterol Suppl 186:109–116PubMed

14.

Price AB (1991) The Sydney system: histological division. J Gastronterol Hepatol 6:209–222

15.

Khulusi S, Mendall MA, Patel P, Levy J, Badva S, Northfield TC (1995) Helicobacter pylori infection density and gastric inflammation in duodenal ulcer and non-ulcer subjects. Gut 37:319–324PubMed

16.

Yamaoka Y, Kita M, Kodama T, Sowai N, Koshima K, Imanishi J (1997) Induction of various cytokines and development of severe mucosal inflammation by cag-A gene-positive Helicobacter pylori strains. Gut 41:442–451PubMedCrossRef

17.

Yamaoka Y, Kita M, Imanishi J, Kashima K, Graham DY (1999) Relation between clinical presentation, Helicobacter pylori density, interleukin 1β and 8 production, and cag-A status. Gut 45:804–811PubMedCrossRef

18.

Plebani M, Basso D, Cassaro M, Brigato L, Scrigner M, Toma A, Di Mario F, Rugge M (1996) Helicobacter pylori serology in patients with chronic gastritis. Am J Gastroenterol 91:954–958PubMed

19.

Plebani M, Basso D, Navaglia F, Di Mario F (1997) Helicobacter pylori genotypes influence serum pepsinogen C levels. Helicobacter 2:172–175PubMed

20.

Kaji T, Ishihara S, Ashizawa N, Hamamoto N, Endo H, Fukuda R, Adachi K, Watanabe M, Nakao M, Kinoshita Y (2002) Adherence of Helicobacter pylori to gastric epithelial cells and mucosal inflammation. J Lab Med 139:244–250CrossRef

21.

Plebani M, Basso D, Scrigner M, Toma A, Di Mario F, Dal Bò N, Samloff IM (1996) Serum pepsinogen C: an useful marker of Helicobacter pylori eradication? J Clin Lab Analysis 10:1–5CrossRef

22.

Chittajallu RS, Dorrian CA, Ardill JE, McColl KE (1992) Effect of Helicobacter pylori on serum pepsinogen I and plasma gastrin in duodenal ulcer patients. Scand J Gastroenterol 27:20–24PubMed

23.

Lorente S, Doiz O, Trinidad Serrano M, Castillo J, Lanas A (2002) Helicobacter pylori stimulates pepsinogen secretion from isolated human peptic cells. Gut 50:13–18PubMedCrossRef

24.

Bodger K, Wyatt JI, Heatley RV (2001) Variation in serum pepsinogens with severity and topography of helicobacter pylori-associated chronic gastritis in dyspeptic patients referred for endoscopy. Helicobacter 6:216–224PubMedCrossRef

25.

Graham DY, Go MF, Lew GM, Genta RM, Rehfeld JF (1993) Helicobacter pylori infection and exaggerated gastrin release: effects of inflammation and progastrin processing. Scand J Gastroenterol 28:690–694PubMed

26.

El Omar EM, Penman ID, Ardill JE, Chittajallu RS, Howie C, McColl KE (1995) Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease. Gastroenterology 109:681–691PubMedCrossRef

27.

Kuipers EJ, Uyterlinde AM, Pena AS, Roosendaal R, Pals G, Nelis GF, Festen HP, Meuwissen SG (1995) Long term sequelae of Helicobacter pylori gastritis. Lancet 345:1525–1528PubMedCrossRef

28.

Sanduleanu S, Bruine ADE, Biemond I, Stridsberg M, Jonkers D, Lundqvist G et al (2003) Ratio between serum IL-8 and pepsinogen A/C: a marker for atrophic body gastritis. Eur J Clin Invest 33:147–154PubMedCrossRef

29.

Rohrer GV, Welsh JD (1967) Correlative study: gastric secretion and histology. Gastroenterology 52:185–191PubMed

30.

El-Omar EM, Oien K, El-Nujumi A, Gillen D, Wirz A, Dahill S, Williams C, Ardill JE, McColl KE (1997) Helicobacter pylori infection and chronic gastritis hyposecretion. Gastroenterology 113:15–24PubMedCrossRef

31.

Gutierrez O, Melo M, Segura AM, Angel A, Genta RM, Graham DY (1997) Cure of Helicobacter pylori infection improves gastric acid secretion in patients with corpus gastritis. Scand J Gastroenterol 32:664–668PubMedCrossRef

32.

Wallace JL, Cucala M, Mugridge K, Parente L (1991) Secretagogue-specific effects of interleukin 1 on gastric secretion. Am J Physiol 261:G559–G564PubMed

33.

Furuta T, Baba S, Takashima M, Futami H, Arai H, Kajimura M, Hanai H, Kaneko E (1998) Effect of Helicobacter pylori infection on gastric Juice pH. Scand J Gastroenterol 33:357–363PubMedCrossRef

34.

Furuta T, El-Omar EM, Fang X, Shirai N, Takashima M, Sugimurra H (2002) Interleukin 1-β polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. Gastroenterology 123:92–105PubMedCrossRef

35.

Sipponen P, Ranta P, Helske T, Kaariainen I, Maki T, Linnala A, Suovaniemi O, Alanko A, Harkonen M (2002) Serum levels of Amidaded Gastrin-17 and pepsinogen I in atrophic gastritis: An observational case-control study. Scand J Gastroenterol 37:785–791PubMed

36.

Vaananen H, Vauhkonen M, Helske T, Kaariainen I, Rausmussen M, Tunturi-Hihnala H, Koskenpato J, Sotka M (2003) Non endoscopic diagnosis of atrophic gastritis with a blood test. Correlation between gastric histology and serum levels of gastrin-17 and pepsinogen I: a multicentre study. Scand J Gastroenterol 15:885–891

Titel: Usefulness of Serum Pepsinogens in Helicobacter pylori Chronic Gastritis: Relationship With Inflammation, Activity, and Density of the Bacterium
verfasst von: Francesco Di Mario
Lucas Giovanni Cavallaro
Ali Mahamat Moussa
Pietro Caruana
Roberta Merli
Andrea Maini
Simone Bertolini
Nadia Dal Bó
Massimo Rugge
Giulia Martina Cavestro
Giovanni Aragona
Mario Plebani
Angelo Franzé
Giorgio Nervi
Publikationsdatum: 01.10.2006
Verlag: Kluwer Academic Publishers-Plenum Publishers
Erschienen in: Digestive Diseases and Sciences / Ausgabe 10/2006
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-006-9206-1

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypotonie | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Usefulness of Serum Pepsinogens in Helicobacter pylori Chronic Gastritis: Relationship With Inflammation, Activity, and Density of the Bacterium

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Viel Bewegung in der Parkinsonforschung

Adjuvante Immuntherapie verlängert Leben bei RCC

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 10/2006

Bleeding Duodenal Varices Successfully Treated with TIPS

Increased Risk of Papillary Thyroid Cancer in Celiac Disease

Central Retinal Vein Thrombosis in a Patient with Ulcerative Colitis

Evaluation of α-Glutathione-S-Transferase as a Biomarker of Lamivudine Therapy for Chronic Hepatitis B

The Effect of Glutamine on Pancreatic Damage in TNBS-Induced Colitis

De Novo Hepatocellular Carcinoma Occurring in a Transplanted Liver: Case Report and Review of the Literature

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Viel Bewegung in der Parkinsonforschung

Adjuvante Immuntherapie verlängert Leben bei RCC

Update Innere Medizin