nach oben

Digestive Diseases and Sciences

Erschienen in:

01.09.2007 | Review Article

Oxidative Stress and Pathogenesis of Inflammatory Bowel Disease: An Epiphenomenon or the Cause?

verfasst von: Ali Rezaie, Robyn D. Parker, Mohammad Abdollahi

Erschienen in: Digestive Diseases and Sciences | Ausgabe 9/2007

Einloggen, um Zugang zu erhalten

Abstract

Crohn’s disease (CD) and ulcerative colitis (UC), known as inflammatory bowel disease (IBD), are fairly common chronic inflammatory conditions of the gastrointestinal tract. Although the exact etiology of IBD remains uncertain, dysfunctional immunoregulation of the gut is believed to be the main culprit. Amongst the immunoregulatory factors, reactive oxygen species are produced in abnormally high levels in IBD. Their destructive effects may contribute to the initiation and/or propagation of the disease. We provided an extensive overview on the evidences from animal and human literature linking oxidative stress to IBD and its activity. Moreover, the effects of antioxidant therapy on IBD patients in randomized, controlled trials were reviewed and the need for further studies elaborated. We also summarized the evidence in support for causality of oxidative stress in IBD.

Brandtzaeg P, Haraldsen G, Rugtveit J (1997) Immunopathology of human inflammatory bowel disease. Semin Immunopathol 18(4):555–589CrossRef

Spitz DR, et al. (2004) Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology. Cancer Metastasis Rev 23(3–4):311–322PubMedCrossRef

Mueller S (2000) Sensitive and nonenzymatic measurement of hydrogen peroxide in biological systems. Free Radic Biol Med 29(5):410–415PubMedCrossRef

Togashi H, et al. (2000) Analysis of hepatic oxidative stress status by electron spin resonance spectroscopy and imaging. Free Radic Biol Med 28(6):846–853PubMedCrossRef

Faulkner K, Fridovich I (1993) Luminol and lucigenin as detectors for O2. Free Radic Biol Med 15(4):447–451PubMedCrossRef

Briggs RT, et al. (1986) Superoxide production by polymorphonuclear leukocytes. A cytochemical approach. Histochemistry 84(4–6):371–378PubMedCrossRef

Pick E, Keisari Y (1980) A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J Immunol Methods 38(1–2):161–170PubMedCrossRef

Halliwell B, Whiteman M (2004) Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol 142(2):231–255PubMedCrossRef

Collins AR, Horvathova E (2001) Oxidative DNA damage, antioxidants and DNA repair: applications of the comet assay. Biochem Soc Trans 29(Pt 2):337–341PubMedCrossRef

10.

Dalle-Donne I, et al. (2003) Protein carbonylation in human diseases. Trends Mol Med 9(4):169–176PubMedCrossRef

11.

Hoffmann JC, et al. (2002) Animal models of inflammatory bowel disease: an overview. Pathobiology 70(3):121–130PubMedCrossRef

12.

Esworthy RS, et al. (2001) Mice with combined disruption of Gpx1 and Gpx2 genes have colitis. Am J Physiol Gastrointest Liver Physiol 281(3):G848–855PubMed

13.

Forrest CM, et al. (2003) Levels of purine, kynurenine and lipid peroxidation products in patients with inflammatory bowel disease. Adv Exp Med Biol 527:395–400PubMed

14.

Geerling BJ, et al. (1999) The relation between antioxidant status and alterations in fatty acid profile in patients with Crohn’s disease and controls. Scand J Gastroenterol 34(11):1108–1116PubMedCrossRef

15.

Genser D, et al. (1999) Status of lipidsoluble antioxidants and TRAP in patients with Crohn’s disease and healthy controls. Eur J Clin Nutr 53(9):675–679PubMedCrossRef

16.

Koutroubakis IE, et al. (2004) Decreased total and corrected antioxidant capacity in patients with inflammatory bowel disease. Dig Dis Sci 49(9):1433–1437PubMedCrossRef

17.

Wendland BE, et al. (2001) Lipid peroxidation and plasma antioxidant micronutrients in Crohn’s disease. Am J Clin Nutr 74(2):259–264PubMed

18.

Erichsen K, et al. (2003) Ferrous fumarate deteriorated plasma antioxidant status in patients with Crohn’s disease. Scand J Gastroenterol 38(5):543–548PubMedCrossRef

19.

Holmes EW, et al. (1998) Glutathione content of colonic mucosa: evidence for oxidative damage in active ulcerative colitis. Dig Dis Sci 43(5):1088–1095PubMedCrossRef

20.

Rezaie A, Eshghtork A, Zamani M, Dehghan G, Taghavi B, Nikfar S, Daryani N, Abdollahi M. Alterations in salivary antioxidants, nitric oxide, and transforming growth factor-beta1 in relation to disease activity in Crohn’s disease patients. Ann N Y Acad Sci (in press)

21.

Miles AM, Grisham MB (1994) Antioxidant properties of aminosalicylates. Methods Enzymol 234:555–572PubMedCrossRef

22.

Aghdassi E, et al. (2003) Antioxidant vitamin supplementation in Crohn’s disease decreases oxidative stress: a randomized controlled trial. Am J Gastroenterol 98(2):348–353PubMed

23.

Trebble TM, et al. (2005) High-dose fish oil and antioxidants in Crohn’s disease and the response of bone turnover: a randomised controlled trial. Br J Nutr 94(2): 253–261PubMedCrossRef

24.

Trebble TM, et al. (2004) Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease. Am J Clin Nutr 80(5):1137–1144PubMed

25.

Geerling BJ, et al. (2000) Nutritional supplementation with N-3 fatty acids and antioxidants in patients with Crohn’s disease in remission: effects on antioxidant status and fatty acid profile. Inflamm Bowel Dis 6(2):77–84PubMedCrossRef

26.

Seidner DL, et al. (2005) An oral supplement enriched with fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis: a randomized, controlled trial. Clin Gastroenterol Hepatol 3(4):358–369PubMedCrossRef

27.

Hendrickson BA, Gokhale R, Cho JH (2002) Clinical aspects and pathophysiology of inflammatory bowel disease. Clin Microbiol Rev 15(1):79–94PubMedCrossRef

28.

Meyer CT, et al. (1981) Hydrogen peroxide colitis: a report of three patients. J Clin Gastroenterol 3(1):31–35PubMedCrossRef

29.

Bilotta JJ, Waye JD (1989) Hydrogen peroxide enteritis: the “snow white” sign. Gastrointest Endosc 35(5):428–430PubMedCrossRef

30.

Riedle B, Kerjaschki D (1997) Reactive oxygen species cause direct damage of Engelbreth-Holm-Swarm matrix. Am J Pathol 151(1):215–231PubMed

31.

Rao RK, et al. (1997) Oxidant-induced disruption of intestinal epithelial barrier function: role of protein tyrosine phosphorylation. Am J Physiol 273(4 Pt 1):G812–G823PubMed

32.

Fries W, et al. (2005) Intestinal permeability and genetic determinants in patients, first-degree relatives, and controls in a high-incidence area of Crohn’s disease in Southern Italy. Am J Gastroenterol 100(12):2730–2736PubMedCrossRef

33.

Buhner S, et al. (2006) Genetic basis for increased intestinal permeability in families with Crohn’s disease: role of CARD15 3020insC mutation? Gut 55(3):342–347PubMedCrossRef

34.

Ding X, et al. (2005) Inducible nitric oxide synthase-dependent DNA damage in mouse model of inflammatory bowel disease. Cancer Sci 96(3):157–163PubMedCrossRef

35.

Tham DM, Whitin JC, Cohen HJ (2002) Increased expression of extracellular glutathione peroxidase in mice with dextran sodium sulfate-induced experimental colitis. Pediatr Res 51(5):641–646PubMed

36.

Ardite E, et al. (2000) Replenishment of glutathione levels improves mucosal function in experimental acute colitis. Lab Invest 80(5):735–744PubMed

37.

Nieto N, et al. (2000) Experimental ulcerative colitis impairs antioxidant defense system in rat intestine. Dig Dis Sci 45(9):1820–1827PubMedCrossRef

38.

Ghazanfari GMB, Yasa N, Ashtaral-Nakhai L, Mohammadirad A, Nikfar S, Dehghan G, Shetab-Boushehri V, Jamshidi H, Khorasani R, Salehnia A, Abdollahi M (2006) Biochemical and histopathological evidences for beneficial effects of Satureja khuzestanica jamzad essential oil on the mouse model of inflammatory bowel diseases. Toxicology Mechanisms Methods 16(7):365–372CrossRefPubMed

39.

Ghafari HYN, Mohammadirad A, Dehghan G, Zamani MJ, Nikfar S, Khorasani S, Minaie B, Abdollahi M (2006 Jun) Protection by Ziziphora clinopoides of acetic acid-induced toxic bowel inflammation through reduction of cellular lipid peroxidation and myeloperoxidase activity. Human Experimental Toxicol 25:325–332CrossRef

40.

Jahanshahi G, et al. (2004) Alterations in antioxidant power and levels of epidermal growth factor and nitric oxide in saliva of patients with inflammatory bowel diseases. Dig Dis Sci 49(11–12):1752–1757PubMedCrossRef

41.

Barbosa DS, et al. (2003) Decreased oxidative stress in patients with ulcerative colitis supplemented with fish oil omega-3 fatty acids. Nutrition 19(10):837–842PubMedCrossRef

42.

Kruidenier L, et al. (2003) Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants. J Pathol 201(1):28–36PubMedCrossRef

43.

Tuzun A, et al. (2002) Oxidative stress and antioxidant capacity in patients with inflammatory bowel disease. Clin Biochem 35(7):569–572PubMedCrossRef

44.

Sampietro GM, et al. (2002) Oxidative stress, vitamin A and vitamin E behaviour in patients submitted to conservative surgery for complicated Crohn’s disease. Dig Liver Dis 34(10):696–701PubMedCrossRef

45.

D’Odorico A, et al. (2001) Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease. Scand J Gastroenterol 36(12):1289–1294PubMedCrossRef

46.

Levy E, et al. (2000) Altered lipid profile, lipoprotein composition, and oxidant and antioxidant status in pediatric Crohn’s disease. Am J Clin Nutr 71(3):807–815PubMed

47.

Chiarpotto E, et al. (1997) Oxidative damage and transforming growth factor beta 1 expression in pretumoral and tumoral lesions of human intestine. Free Radic Biol Med 22(5):889–894PubMedCrossRef

48.

Lih-Brody L, et al. (1996) Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease. Dig Dis Sci 41(10):2078–2086PubMedCrossRef

49.

Cao W, et al. (2004) Hydrogen peroxide contributes to motor dysfunction in ulcerative colitis. Am J Physiol Gastrointest Liver Physiol 286(5):G833–G843PubMedCrossRef

50.

Pelli MA, et al. (1999) Breath alkanes determination in ulcerative colitis and Crohn’s disease. Dis Colon Rectum 42(1):71–76PubMedCrossRef

51.

Hatoum OA, et al. (2003) Acquired microvascular dysfunction in inflammatory bowel disease: loss of nitric oxide-mediated vasodilation. Gastroenterology 125(1):58–69PubMedCrossRef

52.

Koch TR, et al. (2000) Total antioxidant capacity of colon in patients with chronic ulcerative colitis. Dig Dis Sci 45(9):1814–1819PubMedCrossRef

53.

Tsunada S, et al. (2003) Redox imbalance in the colonic mucosa of ulcerative colitis. Scand J Gastroenterol 38(9):1002–1003PubMedCrossRef

54.

Kruidenier L, et al. (2003) Imbalanced secondary mucosal antioxidant response in inflammatory bowel disease. J Pathol 201(1):17–27PubMedCrossRef

55.

Szanto I, et al. (2005) Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease. J Pathol 207(2):164–176PubMedCrossRef

56.

Buffinton GD, Doe WF (1995) Depleted mucosal antioxidant defenses in inflammatory bowel disease. Free Radic Biol Med 19(6):911–918PubMedCrossRef

57.

Reimund JM, et al. (2000) Antioxidant and immune status in active Crohn’s disease: a possible relationship. Clin Nutr 19(1):43–48PubMedCrossRef

58.

Hoffenberg EJ, et al. (1997) Circulating antioxidant concentrations in children with inflammatory bowel disease. Am J Clin Nutr 65(5):1482–1488PubMed

59.

Fernandez-Banares F, et al. (1989) Vitamin status in patients with inflammatory bowel disease. Am J Gastroenterol 84(7):744–748PubMed

60.

Kuroki F, et al. (1993) Multiple vitamin status in Crohn’s disease. Correlation with disease activity. Dig Dis Sci 38(9):1614–1618PubMedCrossRef

61.

Hinks LJ, et al. (1988) Reduced concentrations of selenium in mild Crohn’s disease. J Clin Pathol 41(2):198–201PubMedCrossRef

Titel: Oxidative Stress and Pathogenesis of Inflammatory Bowel Disease: An Epiphenomenon or the Cause?
verfasst von: Ali Rezaie
Robyn D. Parker
Mohammad Abdollahi
Publikationsdatum: 01.09.2007
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 9/2007
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-006-9622-2

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Echinokokkose medikamentös behandeln oder operieren?

06.05.2024 DCK 2024 Kongressbericht

Die Therapie von Echinokokkosen sollte immer in spezialisierten Zentren erfolgen. Eine symptomlose Echinokokkose kann – egal ob von Hunde- oder Fuchsbandwurm ausgelöst – konservativ erfolgen. Wenn eine Op. nötig ist, kann es sinnvoll sein, vorher Zysten zu leeren und zu desinfizieren.

Aquatherapie bei Fibromyalgie wirksamer als Trockenübungen

03.05.2024 Fibromyalgiesyndrom Nachrichten

Bewegungs-, Dehnungs- und Entspannungsübungen im Wasser lindern die Beschwerden von Patientinnen mit Fibromyalgie besser als das Üben auf trockenem Land. Das geht aus einer spanisch-brasilianischen Vergleichsstudie hervor.

Wo hapert es noch bei der Umsetzung der POMGAT-Leitlinie?

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Das Risiko für Vorhofflimmern in der Bevölkerung steigt

02.05.2024 Vorhofflimmern Nachrichten

Das Risiko, im Lauf des Lebens an Vorhofflimmern zu erkranken, ist in den vergangenen 20 Jahren gestiegen: Laut dänischen Zahlen wird es drei von zehn Personen treffen. Das hat Folgen weit über die Schlaganfallgefährdung hinaus.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 9/2007

Colonic Manometry Catheter Placement with Primary Fluoroscopic Guidance

Leukocytapheresis (LCAP) in the Management of Chronic Active Ulcerative Colitis—Results of a Randomized Pilot Trial

Nimesulide Inhibits Crypt Epithelial Cell Proliferation at 6 Hours in the Small Intestine in CD-1 Mice

The Effects of Rosiglitazone, Metformin, and Diet with Exercise in Nonalcoholic Fatty Liver Disease

Development of Specific Antibodies to an ARF Protein in Treated Patients with Chronic HCV Infection