nach oben

Digestive Diseases and Sciences

Erschienen in:

01.02.2008 | Original Paper

Decreased Histamine Catabolism in the Colonic Mucosa of Patients with Colonic Adenoma

verfasst von: Michael A. Kuefner, Hubert G. Schwelberger, Eckhart G. Hahn, Martin Raithel

Erschienen in: Digestive Diseases and Sciences | Ausgabe 2/2008

Einloggen, um Zugang zu erhalten

Abstract

Introduction

Alterations in mucosal histamine degradation play an important role in various gastrotinestinal diseases including colonic adenoma. In humans, histamine can be catabolized either by oxidative deamination by diamine oxidase (DAO) or by ring methylation by histamine N-methyltransferase (HNMT). The significance of HNMT in this context was investigated for the first time in this project.

Methods

About 94 colonic biopsies were endoscopically obtained from 23 patients suffering from colonic adenoma and 26 biopsies from six healthy individuals. Each sample was mechanically homogenized, homogenates were cleared by centrifugation and used for determination of protein and histamine concentrations and enzyme activities of DAO and HNMT by radiometric assay.

Results

In adenoma patients DAO activities were slightly and HNMT activities were significantly decreased in normal mucosa compared to controls. Activities of both enzymes were significantly lower in adenoma tissue than in healthy mucosa in the same patients. A significant correlation was found between HNMT and DAO in all investigated samples. Histamine concentrations were elevated in adenoma patients.

Conclusions

Histamine catabolism is decreased in the colonic mucosa of patients with colonic adenoma.

Markowitz SD, Dawson DM, Willis J, Willson JK (2002) Focus on colon cancer. Cancer Cell 1:233–236PubMedCrossRef

Burt RW (2000) Colon cancer screening. Gastroenterology 119:837–253PubMedCrossRef

Seitz HK, Simanowski UA, Homann N, Waldherr R (1998) Cell proliferation and its evaluation in the colorectal mucosa: effect of ethanol. Z Gastroenterol 36:645–655PubMed

Prichard PJ, Tjandra JJ (1998) Colorectal cancer. Med J Aust 169:493–498PubMed

Hardy RG, Meltzer SJ, Jankowski JA (2000) ABC of colorectal cancer. Molecular basis for risk factors. BMJ 321:886–889PubMedCrossRef

Leslie A, Carey FA, Pratt NR, Steele RJC (2002) The colorectal adenoma-carcinoma sequence. Br J Surg 89:845–860PubMedCrossRef

Villavicencio RT, Rex DK (2000) Colonic adenomas: prevalence and incidence rates, growth rates, and miss rates at colonoscopy. Semin Gatrointest Dis 11:185–193

Srivastava S, Verma M, Henson DE (2001) Biomarkers for early detection of colon cancer. Clin Cancer Res 7:1118–1126PubMed

Kusche J, Mennigen R, Leisten L (1989) Early alterations of rat intestinal diamine oxidase activity by azoxymethane, an intestinal carcinogen. Agents Actions 27:218–220PubMedCrossRef

10.

Raithel M, Ulrich P, Hochberger J, Hahn EG (1998) Measurement of gut diamine oxidase activity: diamine oxidase as a new biologic marker of colorectal proliferation? Ann NY Acad Sci 859:262–266PubMedCrossRef

11.

Pearce FL (1991) Biological effects of histamine: an overview. Agents Actions 33:4–7PubMedCrossRef

12.

Norrby K (1985) Evidence of mast-cell histamine being mitogenic in intact tissue. Agents Actions 16:287–290PubMedCrossRef

13.

Argento-Cerú MP, Autouri F (1985) Localization of diamine oxidase in animal tissues. In: Mondovi B (ed) Structure and functions of amine oxidases. CRC Press, Boca Raton pp 89–104

14.

Kusche J, Mennigen R, Erpenbach K (1988) The intestinal diamine oxidase activity under the influence of adaptive proliferation of the intestinal mucosa – a proliferation terminating principle? Agents Actions 23:354–356PubMedCrossRef

15.

Code CF (1985) Histamine – whither now? Can J Physiol Pharmacol 63:746–750PubMed

16.

Kusche J, Mennigen R, Leisten L, Krakamp B (1988) Large bowel tumour promotion by diamine oxidase inhibition: animal model and clinical aspects. Adv Exp Med Biol 250:745–752PubMed

17.

Pacifici GM, Donatelli P, Giuliani L (1992) Histamine N-methyltransferase: inhibition by drugs. Br J Clin Pharmac 34:322–327

18.

Sattler J, Hesterberg R, Lorenz W, Schmidt U, Crombach M (1985) Inhibition of human and canine diamine oxidase by drugs used in an intensive care unit: relevance for clinical side effects? Agents Actions 16:91–94PubMedCrossRef

19.

Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150(1):15076–15085CrossRef

20.

Kusche J, Richter H, Hesterberg R, Schmidt J, Lorenz W (1973) Comparison of the ¹⁴C-Putrescine assay with the NADH test for the determination of diamine oxidase: description of a standard procedure with a high precision and an improved accuracy. Agents Actions 3:148–156PubMedCrossRef

21.

Schwelberger HG, Klocker J, Sattler J, Bodner E (1995) Determination of the activity of diamine oxidase in extremely small tissue samples. Inflamm Res 44:94–95CrossRef

22.

Brown DD, Tomchick R, Axelrod J (1959) The distribution and properties of a histamine-methylating enzyme. J Biol Chem 234:2948–2950PubMed

23.

Barth H, Lorenz W, Niemeyer I (1973) Inhibition and activation of histamine methyltransferase by methylated histamines. Hoppe Seylers Z Physiol Chem 354:1021–1026PubMed

24.

Beaven MA, Robinson-White A, Roderick NB, Kauffmann GL (1982) The demonstration of histamine release in clinical conditions: a review of past and present assay procedures. Klin Wochenschr 60:873–881PubMedCrossRef

25.

Verburg KM, Bowsher RR, Henry DP (1983) A new radioenzymatic assay for histamine using purified histamine N-methyltransferase. Life Sci 32:2855–2867PubMedCrossRef

26.

Kufner MA, Ulrich P, Raithel M, Schwelberger HG (2001) Determination of the histamine degradation capacity in extremely small human colon samples. Inflamm Res 50(Suppl 2):96–97

27.

Hesterberg R, Sattler J, Lorenz W, Stahlknecht CD, Barth H, Crombach M (1984) Histamine content, diamine oxidase activity and histamine methyltransferase activity in human tissues: fact or fictions? Agents Actions 14:325–334PubMedCrossRef

28.

Schwelberger HG, Bodner E (1997) Purification and characterization of diamine oxidase from porcine kidney and intestine. Biochim Biophys Acta 1340:152–164PubMed

29.

Brown DD, Tomchick R, Axelrod J (1959) The distribution and properties of a histamine-methylating enzyme. J Biol Chem 234:2948–2950PubMed

30.

Raithel M, Horauf AM, Matek M, Baenkler HW (1989) Kinetics of histamine released from rectal mucosa. Agents Actions 28:164–167PubMedCrossRef

31.

Backhaus B, Weidenhiller M, Bijlsma P, Hahn EG, Raithel M (2004) Evaluation of spontaneous histamine release from colorectal mucosa in patients with colorectal adenoma, patients with gastrointestinally mediated allergy and in a healthy control group. Inflamm Res 53(Suppl 1):87–88CrossRef

32.

Petersen J, Raithel M, Schwelberger HG (2002) Histamine N-methyltransferase and diamine oxidase gene polymorphisms in patients with inflammatory and neoplasitc intstinal dieases. Inflamm Res 51(Suppl 1):91–92

33.

Adams WJ, Lawson JA, Morris DL (1994) Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth. Gut 35:1632–1636PubMedCrossRef

34.

Watson SA, Wilkinson LJ, Robertson JFR, Hardcastle JD (1993) Effect of histamine on the growth of human gastrointestinal tumour: reversal by cimetidine. Gut 34:1091–1096PubMedCrossRef

35.

Bodmer S, Imark C, Kneubühl M (1999) Biogenic amines in food: histamine and food processing. Inflamm res 48:296–300PubMedCrossRef

36.

Wantke F, Jarisch J, Götz M (1993) Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronic headaches. Clin Exp Allergy 23:982–985PubMedCrossRef

37.

Raithel M, Kufner M, Ulrich P, Hahn EG (1999) The involvement of the histamine degradation pathway by diamine oxidase in manifest gastrointestinal allergies. Inflamm Res 48(Suppl 1):75–76CrossRef

38.

Weidenhiller M, Raithel M, Winterkamp S, Otte P, Stolper J, Hahn EG (2000) Methylhistamine in Crohn´s disease (CD): increased production and elevated urine excretion correlates with disease activity. Inflamm Res 49(Suppl 1):35–36CrossRef

Titel: Decreased Histamine Catabolism in the Colonic Mucosa of Patients with Colonic Adenoma
verfasst von: Michael A. Kuefner
Hubert G. Schwelberger
Eckhart G. Hahn
Martin Raithel
Publikationsdatum: 01.02.2008
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 2/2008
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-007-9861-x

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypotonie | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Decreased Histamine Catabolism in the Colonic Mucosa of Patients with Colonic Adenoma

Abstract

Introduction

Methods

Results

Conclusions

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Viel Bewegung in der Parkinsonforschung

Adjuvante Immuntherapie verlängert Leben bei RCC

Update Innere Medizin

Springer Medizin

Abstract

Introduction

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2008

Spontaneous and Bolus-induced Motility in the Chronically Obstructed Guinea-Pig Small Intestine In vitro

Nizatidine and Gastric Emptying in Functional Dyspepsia

Phase-II Study of Gemcitabine and Cisplatin in Patients with Metastatic Biliary and Gallbladder Cancer

Functional Expression of μ-Opioid Receptors in the Human Colon Cancer Cell Line, HT-29, and their Localization in Human Colon

Clinical Outcomes of Patients with Liver Cirrhosis Who Underwent Curative Surgery for Gastric Cancer: A Retrospective Multi-center Study

Clinical Features and Outcome of Chronic Viral Hepatitis with Acute Exacerbation in Patients with Concurrent Infections of Hepatitis B and C Virus

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Viel Bewegung in der Parkinsonforschung

Adjuvante Immuntherapie verlängert Leben bei RCC

Update Innere Medizin