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01.10.2015 | SHORT REPORT

BRAF-mutated clear cell sarcoma is sensitive to vemurafenib treatment

verfasst von: Svetlana A. Protsenko, Anna I. Semionova, Yuri I. Komarov, Svetlana N. Aleksakhina, Alexandr O. Ivantsov, Aglaya G. Iyevleva, Evgeny N. Imyanitov

Erschienen in: Investigational New Drugs | Ausgabe 5/2015

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Summary

We report a patient with a metastatic relapse of clear cell sarcoma, whose tumor harbored BRAF V600E mutation. Standard chemotherapy with doxorubicin and ifosfamide failed to slow the disease progression. Subsequent administration of vemurafenib (960 mg twice a day) resulted in complete tumor response after 8 weeks of treatment. Literature data on the use of vemurafenib and dabrafenib in non-melanoma BRAF-mutated tumors are reviewed.

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Titel: BRAF-mutated clear cell sarcoma is sensitive to vemurafenib treatment
verfasst von: Svetlana A. Protsenko
Anna I. Semionova
Yuri I. Komarov
Svetlana N. Aleksakhina
Alexandr O. Ivantsov
Aglaya G. Iyevleva
Evgeny N. Imyanitov
Publikationsdatum: 01.10.2015
Verlag: Springer US
Erschienen in: Investigational New Drugs / Ausgabe 5/2015
Print ISSN: 0167-6997
Elektronische ISSN: 1573-0646
DOI: https://doi.org/10.1007/s10637-015-0280-0

Neu im Fachgebiet Onkologie

25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

BRAF-mutated clear cell sarcoma is sensitive to vemurafenib treatment

Summary

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Springer Medizin

Summary

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