Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Inflammation
Erschienen in: Inflammation 3/2008

01.06.2008

Low Level Laser Therapy (LLLT) Decreases Pulmonary Microvascular Leakage, Neutrophil Influx and IL-1β Levels in Airway and Lung from Rat Subjected to LPS-Induced Inflammation

verfasst von: F. Aimbire, A. P. Ligeiro de Oliveira, R. Albertini, J. C. Corrêa, C. B. Ladeira de Campos, J. P. Lyon, J. A. Silva Jr., M. S. Costa

Erschienen in: Inflammation | Ausgabe 3/2008

Einloggen, um Zugang zu erhalten

Abstract

Background and Objective

Low level laser therapy (LLLT) is a known anti-inflammatory therapy. Herein we studied the effect of LLLT on lung permeability and the IL-1β level in LPS-induced pulmonary inflammation.

Study Design/Methodology

Rats were divided into 12 groups (n = 7 for each group). Lung permeability was measured by quantifying extravasated albumin concentration in lung homogenate, inflammatory cells influx was determined by myeloperoxidase activity, IL-1β in BAL was determined by ELISA and IL-1β mRNA expression in trachea was evaluated by RT-PCR. The rats were irradiated on the skin over the upper bronchus at the site of tracheotomy after LPS.

Results

LLLT attenuated lung permeability. In addition, there was reduced neutrophil influx, myeloperoxidase activity and both IL-1β in BAL and IL-1β mRNA expression in trachea obtained from animals subjected to LPS-induced inflammation.

Conclusion

LLLT reduced the lung permeability by a mechanism in which the IL-1β seems to have an important role.
Literatur
1.
Kips, J. C., J. Tavernier, and R. A. Pauwels. 1992. Tumor necrosis factor causes bronchial hyperresponsiveness in rats. Am. Rev. Respir. Dis. 145:332–336.PubMed
2.
Miller, D. L., K. Welty-Wolf, M. S. Carraway, M. Ezban, A. Ghio, H. Suliman, and C. A. Piantadosi. 2002. Extrinsic coagulation blockade attenuates lung injury and pro-inflammatory cytokine release after intratracheal lipopolysaccharide. Am. J. Respir. Cell Mol. Biol. 26(6):650–658.PubMed
3.
Jansson, A. H., C. Eriksson, and X. Wang. 2004. Lung inflammatory responses and hyperinflation induced by an intratracheal exposure to lipopolysaccharide in rats. Lung 182(3):163–171.PubMedCrossRef
4.
Lappalainen, U., J. A. Whitsett, S. E. Wert, J. W. Tichelaar, and K. Bry. 2005. Interleukin-1b causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. Am. J. Respir. Cell Mol. Biol. 32:311–318.
5.
Johnson, V. J., B. Yucesoy, and M. I. Luster. 2005. Prevention of IL-1 signaling attenuates airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma. J. Allergy Clin. Immunol. 116(4):851–858.PubMedCrossRef
6.
Wang, C. C., C. L. Fu, Y. H. Yang, Y. C. Lo, L. C. Wang, Y. H. Chuang, and D. M. Chiang. 2006. Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma. Gene Ther. 13(19):1414–1421.PubMedCrossRef
7.
Rose, C. E. Jr, C. A. Juliano, D. E. Tracey, T. Yoshimura, and S. M. Fu. 1994. Role of interleukin-1 in endotoxin-induced lung injury in the rat. Am. J. Respir. Cell Mol. Biol. 10(2):214–221.PubMed
8.
Warren, J. S. 1992. Relationship between interleukin-1 beta and platelet-activating factor in the pathogenesis of acute immune complex alveolitis in the rat. Am. J. Pathol. 141(3):551–560.PubMed
9.
Ware, L. B., and M. A. Matthay. 2000. The acute respiratory distress syndrome. N. Engl. J. Med. 342:1334–1349.PubMedCrossRef
10.
Bachofen, M., and E. R. Weibel. 1982. Structural alterations of lung parenchyma in the adult respiratory syndrome. Clin. Chest Med. 3:35–56.PubMed
11.
Dudek, S. M., and J. G. N. Garcia. 2001. Cytoskeleton regulation of pulmonary vascular permeability. J. Appl. Physiol. 91:1487–1500.PubMed
12.
Kao, S. J., D. D. Liu, C. F. Su, and H. I. Chen. 2007. Niacinamide abrogates the organ dysfunction and acute lung injury caused by endotoxin. J. Cardiovasc. Pharmacol. 50(3):333–342.PubMedCrossRef
13.
Frank, J. A., J. F. Pittet, C. Wray, and M. A. Matthay. 2008. Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Thorax. 63:147–153.PubMedCrossRef
14.
Cazzola, M., and R. Polosa. 2006. Anti-TNF-alpha and Th1 cytokine-directed therapies for the treatment of asthma. Curr. Opin. Allergy Clin. Immunol. 6(1):43–50.PubMedCrossRef
15.
Stirling, R. J., and K. F. Chung. 2000. Future treatments of allergic diseases and asthma. Br. Med. Bull. 56(4):1037–1053.PubMedCrossRef
16.
Bjordal, J. M., M. I. Johnson, V. Iversen, F. Aimbire, and R. A. B. Lopes-Martins. 2006. Low Level Laser Therapy (LLLT) and acute pain: A systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials. Photomed. Laser Surg. 24(2):160–170.CrossRef
17.
Milojevic, M., and V. Kuruc. 2004. The role of physical rehabilitation in the treatment of exudative pleurisy. Med. Pregl. 57(1–2):13–17.PubMedCrossRef
18.
Landyshev, I. U. S., N. V. Avdeeva, N. D. Goborov, N. P. Krasavina, G. A. Tikhonova, and S. I. Tkacheva. 2002. Efficacy of low intensity laser irradiation and sodium nedocromil in the complex treatment of patients with bronchial asthma. Ter. Arkh. 74(3):25–28.PubMed
19.
Aimbire, F., R. A. B. Lopes-Martins, R. Albertini, M. T. T. Pacheco, H. C. Castro-Faria-Neto, P. S. L. M. Leonardo, and J. M. Bjordal. 2007. Effect of Low-Level Laser therapy on hemorrhagic lesions by immune complex in rat lungs. Photomed. and Laser Surg. 25(2):112–117.CrossRef
20.
Aimbire, F., J. M. Bjordal, V. V. Iversen, R. Albertini, L. Frigo, M. T. Pacheco, H. C. Castro-Faria-Neto, M. C. Chavantes, R. M. Labat, and R. A. Lopes-Martins. 2006. Low level laser therapy partially restores trachea muscle relaxation response in rats with tumor necrosis factor alpha-mediated smooth airway muscle dysfunction. Lasers Surg. Med. 38(8):773–778.PubMedCrossRef
21.
Akeson, A. L., C. W. Woods, L. C. Hsieh, R. A. Bohnke, B. L. Ackermann, K. Y. Chan, J. L. Robinson, S. D. Yanofsky, J. W. Jacobs, R. W. Barrett, and T. L. Bowlin. 1996. AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J. Biol. Chem. 271(48):30517–30523.PubMedCrossRef
22.
Shimada, H., N. Hasegawa, H. Koh, S. Tasaka, M. Shimizu, W. Yamada, T. Nishimura, K. Amakawa, M. Kohno, M. Sawafuji, K. Nakamura, S. Fujishima, K. Yamaguchi, and A. Ishizaka. 2006. Effects of initial passage of endotoxin through the liver on the extent of acute lung injury in a rat model. Shock 26(3):311–315.PubMedCrossRef
23.
Wang, L. F., M. Patel, H. Razavi, S. Weicker, M. Joseph, D. McCormack, and S. Mehta. 2002. Role of inducible nitric oxide synthase in pulmonary microvascular protein leak in murine sepsis. Am. J. Respir. Crit. Care Med. 165:1634–1639.CrossRef
24.
Tavares de Lima, W., A. A. Steil, M. Russo, N. Starobinas, C. F. Teixeira, and S. Jancar. 1998. Lipid mediators, tumor necrosis factor and nitric oxide and their interactions in immune-complex-induced lung injury. Eur. J. Pharmacol. 358(1):69–75.PubMedCrossRef
25.
Goldblum, S. E., K. M. Wu, and M. Jay. 1985. Lung myeloperoxidase as a measure pf pulmonary leukostasis in rabbits. J. Appl. Physiol. 59:1978–1985.PubMed
26.
Dinarello, C. A. 1996. Biologic basis of interleukin-1 in disease. Blood 87(6):2095–2147.PubMed
27.
Borish, L., J. J. Mascali, J. Dishuck, W. R. Beam, R. J. Martin, and L. J. Rosenwasser. 1992. Detection of alveolar macrophage-derived IL-1b in asthma. Inhibition with corticosteroids. J. Immunol. 149:3340–3346.
28.
Peng, X., P. M. Hassoun, S. Sammani, B. J. McVerry, M. J. Burne, H. Rabb, D. Pearse, R. M. Tuder, and J. G. N. Garcia. 2004. Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. Am. J. Respir. Crit. Care Med. 169:1245–1251.PubMedCrossRef
29.
Gerlach, H., D. Keh, A. Semmerow, T. Busch, K. Lewandowski, D. M. Pappert, R. Rossaint, and K. J. Falke. 2003. Dose–response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: a prospective, randomized, controlled study. Am. J. Respir. Crit. Care Med. 167(7):1008–1015.PubMedCrossRef
30.
Pilkington, C. A., and L. R. Weddenburg. 2005. Pediatric idiopathic inflammatory muscle disease: recognition and management. Drugs 65(10):1355–1365.PubMedCrossRef
31.
Chung, F. 2001. Anti-inflammatory cytokines in asthma and allergy: interleukin-10, interleukin-12, interferon-g. Mediat. Inflamm. 10:51–59.CrossRef
32.
Alagappan, V. K., S. McKay, A. Widyastuti, I. M. Garrelds, A. J. Bogers, H. C. Hoogsteden, S. J. Hirst, and H. S. Sharma. 2005. Pro-inflammatory cytokines upregulate mRNA expression and secretion of vascular endothelial growth factor in cultured human airway smooth muscle cells. Cell Biochem. Biophys. 43(1):119–129.PubMedCrossRef
33.
Kupfner, J. G., J. J. Arcaroli, H. K. Yum, S. G. Nadler, K. Y. Yang, and E. Abraham. 2001. Role of NF-kappaB in endotoxemia-induced alterations of lung neutrophil apoptosis. J. Immunol. 167(12):7044–7051.PubMed
34.
Niwa, M., A. Hara, Y. Kanamori, D. Hatakeyama, M. Saio, T. Takami, H. Matsuno, O. Kozawa, and T. Uematsu. 2000. Nuclear factor-kappaB activates dual inhibition sites in the regulation of tumor necrosis factor-alpha-induced neutrophil apoptosis. Eur. J. Pharmacol. 407(3):211–219.PubMedCrossRef
35.
Coras, B., U. Hohenleutner, M. Landthaler, and S. Hohenleutner. 2005. Early recurrence of eruptive vellus hair cysts after Er:YAG laser therapy: case report and review of the literature. Dermatol. Surg. 31(12):1741–1744.PubMed
36.
Witman, P. M., A. M. Wagner, K. Scherer, M. Waner, and I. J. Frieden. 2006. Complications following pulsed dye laser treatment of superficial hemangiomas. Lasers Surg. Med. 38(2):116–123.PubMedCrossRef
37.
Lee, H. W., S. J. Ahn, M. W. Lee, J. H. Choi, K. C. Moon, and J. K. J. Koh. 2006. Pseudomelanoma following laser therapy. Eur. Acad. Dermatol. Venereol. 20(3):342–344.CrossRef
38.
Chan, H. H., C. H. Yang, J. C. Leung, W. I. Wei, and K. N. Lai. 2007. An animal study of the effects on p16 and PCNA expression of repeated treatment with high-energy laser and intense pulsed light exposure. Lasers Surg. Med. 39(1):8–13.PubMedCrossRef
39.
Dinarello, C. A. 2005. Interkeukin-1b. Crit. Care Med. 33(12):460–462.CrossRef
40.
Albertini, R., F. Aimbire, A. B. Villaverde, J. A. Silva Jr, and M. S. Costa. 2007. COX-2 mRNA expression decreases in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low level laser therapy. Inflamm. Res. 56:1–2.CrossRef
Metadaten
Titel
Low Level Laser Therapy (LLLT) Decreases Pulmonary Microvascular Leakage, Neutrophil Influx and IL-1β Levels in Airway and Lung from Rat Subjected to LPS-Induced Inflammation
verfasst von
F. Aimbire
A. P. Ligeiro de Oliveira
R. Albertini
J. C. Corrêa
C. B. Ladeira de Campos
J. P. Lyon
J. A. Silva Jr.
M. S. Costa
Publikationsdatum
01.06.2008
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 3/2008
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-008-9064-4

Weitere Artikel der Ausgabe 3/2008

Inflammation 3/2008 Zur Ausgabe

OriginalPaper

Dehydroepiandrosterone and Dehydroepiandrosterone Sulphate in Atopic Allergy and Chronic Urticaria

OriginalPaper

Anti-inflammatory Effects of Ethanol Extract from Kummerowia striata (Thunb.) Schindl on LPS-Stimulated RAW 264.7 Cell

OriginalPaper

C-Reactive Protein is Linked to Lower Cognitive Performance in Overweight and Obese Women

OriginalPaper

Spermine and Endothelial Damage During Endotoxemia

OriginalPaper

Serum Pro-hepcidin Levels in Rheumatoid Arthritis and Systemic Lupus Erythematosus

OriginalPaper

IL-17 Producing γδ T Cells are Required for a Controlled Inflammatory Response after Bleomycin-induced Lung Injury

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise