Erschienen in:
01.06.2014 | Fertility Preservation
Administration of DHEA augments progesterone production in a woman with low ovarian reserve being transplanted with cryopreserved ovarian tissue
verfasst von:
Susanne Strauss, Tine Greve, Erik Ernst, Matthiaos Fraidakis, Jurgis Gedis Grudzinskas, Claus Yding Andersen
Erschienen in:
Journal of Assisted Reproduction and Genetics
|
Ausgabe 6/2014
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Excerpt
In recent years cryopreservation of ovarian tissue prior to potentially gonadotoxic treatment for malignant disease has proved to be an option for preservation of the reproductive function including fertility [
1]. Following successful cancer treatment women have chosen to have transplantation of their frozen-thawed tissue if ovarian failure occurred as a consequence of cancer treatment. The autotransplanted tissue has in various centers resulted in the re-establishment of ovarian function leading to the return of fertility and the birth of healthy children [
2,
3]. However, the ovarian reserve in the transplanted tissue typically is very low as currently only a limited number of follicles survive the entire procedure including freezing, thawing and transplantation [
4]. This diminished reserve is reflected by persistent low levels of AMH [
4], limiting the efficacy of controlled ovarian stimulation (COS) with exogenous FSH. …