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Erschienen in: Journal of Assisted Reproduction and Genetics 6/2014

01.06.2014 | Fertility Preservation

Administration of DHEA augments progesterone production in a woman with low ovarian reserve being transplanted with cryopreserved ovarian tissue

verfasst von: Susanne Strauss, Tine Greve, Erik Ernst, Matthiaos Fraidakis, Jurgis Gedis Grudzinskas, Claus Yding Andersen

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 6/2014

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Excerpt

In recent years cryopreservation of ovarian tissue prior to potentially gonadotoxic treatment for malignant disease has proved to be an option for preservation of the reproductive function including fertility [1]. Following successful cancer treatment women have chosen to have transplantation of their frozen-thawed tissue if ovarian failure occurred as a consequence of cancer treatment. The autotransplanted tissue has in various centers resulted in the re-establishment of ovarian function leading to the return of fertility and the birth of healthy children [2, 3]. However, the ovarian reserve in the transplanted tissue typically is very low as currently only a limited number of follicles survive the entire procedure including freezing, thawing and transplantation [4]. This diminished reserve is reflected by persistent low levels of AMH [4], limiting the efficacy of controlled ovarian stimulation (COS) with exogenous FSH. …
Literatur
1.
Zurück zum Zitat Rosendahl M, Schmidt KT, Ernst E, Rasmussen PE, Loft A, Byskov AG, et al. Cryopreservation of ovarian tissue for a decade in Denmark—an overview of the technique. Reprod Med Online. 2011;22:162–71.CrossRef Rosendahl M, Schmidt KT, Ernst E, Rasmussen PE, Loft A, Byskov AG, et al. Cryopreservation of ovarian tissue for a decade in Denmark—an overview of the technique. Reprod Med Online. 2011;22:162–71.CrossRef
2.
Zurück zum Zitat Andersen CY, Silber SJ, Berghold SH, Jorgensen JS, Ernst E. Long-term duration of function of ovarian tissue transplants: case reports. Reprod Biomed Online. 2012;25:128–32.PubMedCrossRef Andersen CY, Silber SJ, Berghold SH, Jorgensen JS, Ernst E. Long-term duration of function of ovarian tissue transplants: case reports. Reprod Biomed Online. 2012;25:128–32.PubMedCrossRef
3.
Zurück zum Zitat Donnez J, Dolmans MM, Pellicer A, Diaz C, Sanchez M, Schmidt KT, et al. Restoration of ovarian activity and pregnancies after transplantation of cryopreserved ovarian tissue. A review. Fertil Steril. 2013;99:1503–13.PubMedCrossRef Donnez J, Dolmans MM, Pellicer A, Diaz C, Sanchez M, Schmidt KT, et al. Restoration of ovarian activity and pregnancies after transplantation of cryopreserved ovarian tissue. A review. Fertil Steril. 2013;99:1503–13.PubMedCrossRef
4.
Zurück zum Zitat Greve T, Schmidt KT, Kristensen SG, Ernst E, Andersen CY. Evaluation of the ovarian reserve in women transplanted with frozen and thawed ovarian cortical tissue. Fertil Steril. 2012;97:1394–8.PubMedCrossRef Greve T, Schmidt KT, Kristensen SG, Ernst E, Andersen CY. Evaluation of the ovarian reserve in women transplanted with frozen and thawed ovarian cortical tissue. Fertil Steril. 2012;97:1394–8.PubMedCrossRef
5.
Zurück zum Zitat Sönmezer M, Ozmen B, Cil AP, Ozkavukçu S, Taşçi T, Olmuş H, et al. Dehydroepiandrosterone supplementation improves ovarian response and cycle outcome in poor responders. Reprod Biomed Online. 2009;19:508–13.PubMedCrossRef Sönmezer M, Ozmen B, Cil AP, Ozkavukçu S, Taşçi T, Olmuş H, et al. Dehydroepiandrosterone supplementation improves ovarian response and cycle outcome in poor responders. Reprod Biomed Online. 2009;19:508–13.PubMedCrossRef
6.
Zurück zum Zitat Gleicher N, Kim A, Weghofer A, Shohat-Tal A, Lazzaroni E, Lee HJ, et al. Starting and resulting testosterone levels after androgen supplementation determine at all ages in vitro fertilization (IVF) pregnancy rates in women with diminished ovarian reserve (DOR). J Assist Reprod Genet. 2013;30:49–62.PubMedCentralPubMedCrossRef Gleicher N, Kim A, Weghofer A, Shohat-Tal A, Lazzaroni E, Lee HJ, et al. Starting and resulting testosterone levels after androgen supplementation determine at all ages in vitro fertilization (IVF) pregnancy rates in women with diminished ovarian reserve (DOR). J Assist Reprod Genet. 2013;30:49–62.PubMedCentralPubMedCrossRef
7.
8.
Zurück zum Zitat Nielsen ME, Rasmussen IA, Kristensen SG, Christensen ST, Møllgård K, Wreford Andersen E, et al. Expression of androgen-receptor mRNA in granulosa cells from human small antral follicles and the corresponding follicular fluid concentrations of androgens are positively correlated to granulosa cell FSH receptor mRNA expression. Mol Hum Reprod. 2011;17:63–70.PubMedCrossRef Nielsen ME, Rasmussen IA, Kristensen SG, Christensen ST, Møllgård K, Wreford Andersen E, et al. Expression of androgen-receptor mRNA in granulosa cells from human small antral follicles and the corresponding follicular fluid concentrations of androgens are positively correlated to granulosa cell FSH receptor mRNA expression. Mol Hum Reprod. 2011;17:63–70.PubMedCrossRef
9.
Zurück zum Zitat Panjari M, Davis SR. DHEA therapy for women: effect on sexual function and wellbeing. Hum Reprod Update. 2007;13:239–48.PubMedCrossRef Panjari M, Davis SR. DHEA therapy for women: effect on sexual function and wellbeing. Hum Reprod Update. 2007;13:239–48.PubMedCrossRef
10.
Zurück zum Zitat Schmidt KLT, Yding Andersen C, Starup J, Loft A, Byskov AG, Nyboe Andersen A. Orthotophic autotransplantation of cryopreserved ovarian tissue to a woman cured of cancer. Follicular growth, steroid production and oocyte retrieval. Reprod Biomed Online. 2004;8:448–53.CrossRef Schmidt KLT, Yding Andersen C, Starup J, Loft A, Byskov AG, Nyboe Andersen A. Orthotophic autotransplantation of cryopreserved ovarian tissue to a woman cured of cancer. Follicular growth, steroid production and oocyte retrieval. Reprod Biomed Online. 2004;8:448–53.CrossRef
11.
Zurück zum Zitat Genazzani AR, Pluchino N, Begliuomini S, Stomati M, Bernardi F, Pieri M, et al. Long-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal women. Gynecol Endocrinol. 2006;22:627–35.PubMedCrossRef Genazzani AR, Pluchino N, Begliuomini S, Stomati M, Bernardi F, Pieri M, et al. Long-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal women. Gynecol Endocrinol. 2006;22:627–35.PubMedCrossRef
12.
Zurück zum Zitat Rosendahl M, Loft A, Byskov AG, Ziebe S, Schmidt KT, Andersen AN, et al. Biochemical pregnancy after fertilization of an oocyte aspirated from a heterotopic autotransplant of cryopreserved ovarian tissue: case report. Hum Reprod. 2006;21:2006–9.PubMedCrossRef Rosendahl M, Loft A, Byskov AG, Ziebe S, Schmidt KT, Andersen AN, et al. Biochemical pregnancy after fertilization of an oocyte aspirated from a heterotopic autotransplant of cryopreserved ovarian tissue: case report. Hum Reprod. 2006;21:2006–9.PubMedCrossRef
13.
Zurück zum Zitat Genazzani AR, Inglese S, Lombardi I, Pieri M, Bernardi F, Genazzani AD, et al. Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency. Aging Male. 2004;7:133–43.PubMedCrossRef Genazzani AR, Inglese S, Lombardi I, Pieri M, Bernardi F, Genazzani AD, et al. Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency. Aging Male. 2004;7:133–43.PubMedCrossRef
14.
Zurück zum Zitat Labrie F, Labrie C. DHEA and intracrinology at menopause, a positive choice for evolution of the human species. Climacteric. 2013;16:205–13.PubMedCrossRef Labrie F, Labrie C. DHEA and intracrinology at menopause, a positive choice for evolution of the human species. Climacteric. 2013;16:205–13.PubMedCrossRef
15.
Zurück zum Zitat Mahesh VB. Hirsutism, virilism, polycystic ovarian disease, and the steroid-gonadotropin-feedback system: a career retrospective. Am J Physiol Endocrinol Metab. 2012;302:E4–18.PubMedCentralPubMedCrossRef Mahesh VB. Hirsutism, virilism, polycystic ovarian disease, and the steroid-gonadotropin-feedback system: a career retrospective. Am J Physiol Endocrinol Metab. 2012;302:E4–18.PubMedCentralPubMedCrossRef
16.
Zurück zum Zitat Bosch E, Labarta E, Crespo J, Simón C, Remohí J, Jenkins J, et al. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod. 2010;25:2092–100.PubMedCrossRef Bosch E, Labarta E, Crespo J, Simón C, Remohí J, Jenkins J, et al. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod. 2010;25:2092–100.PubMedCrossRef
17.
Zurück zum Zitat Yding Andersen C, Bungum L, Nyboe Andersen A, Humaidan P. Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate. Reprod Biomed Online. 2011;23:187–95.PubMedCrossRef Yding Andersen C, Bungum L, Nyboe Andersen A, Humaidan P. Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate. Reprod Biomed Online. 2011;23:187–95.PubMedCrossRef
Metadaten
Titel
Administration of DHEA augments progesterone production in a woman with low ovarian reserve being transplanted with cryopreserved ovarian tissue
verfasst von
Susanne Strauss
Tine Greve
Erik Ernst
Matthiaos Fraidakis
Jurgis Gedis Grudzinskas
Claus Yding Andersen
Publikationsdatum
01.06.2014
Verlag
Springer US
Erschienen in
Journal of Assisted Reproduction and Genetics / Ausgabe 6/2014
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-014-0214-3

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