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Journal of Clinical Immunology

Erschienen in:

01.10.2011

Altered Peripheral Invariant Natural Killer T Cells in Atopic Dermatitis

verfasst von: Edit Gyimesi, Georgina Nagy, Éva Remenyik, Sándor Sipka, Margit Zeher, Tamás Bíró, Andrea Szegedi

Erschienen in: Journal of Clinical Immunology | Ausgabe 5/2011

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Abstract

Background

Conflicting data exist on the number of invariant NKT (iNKT) cells in atopic dermatitis (AD); furthermore, no data have been published on their functional capacity.

Methods

The frequency and number of circulating CD3+6B11+ iNKT cells and their CD4+ and CD4− subpopulations were evaluated in peripheral blood obtained from 41 patients with AD by four-color flow cytometry. Likewise, functional properties of iNKT cells were measured by five-color intracellular cytokine staining.

Results

The number and percentage of total iNKT cells and their CD4/CD8 subpopulations were significantly lower than the controls. Of further importance, the CD4−CD8− (double negative, DN) iNKT subgroup showed the strongest positive correlation with total iNKT cells. In addition, the DN subgroup exhibited the most pronounced functional alteration with significantly decreased levels of intracellular IFNγ and significantly increased levels of intracellular IL-4 in AD patients compared with the controls.

Conclusion

The significantly altered number and cytokine production of iNKT cells from AD patients suggests that these cells may play an important role in the pathogenesis of AD.

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Titel: Altered Peripheral Invariant Natural Killer T Cells in Atopic Dermatitis
verfasst von: Edit Gyimesi
Georgina Nagy
Éva Remenyik
Sándor Sipka
Margit Zeher
Tamás Bíró
Andrea Szegedi
Publikationsdatum: 01.10.2011
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 5/2011
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-011-9551-5

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Abstract

Background

Methods

Results

Conclusion

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