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Journal of Community Health
Erschienen in: Journal of Community Health 6/2020

12.09.2020 | COVID-19 | Original Paper Zur Zeit gratis

Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis

verfasst von: Farha Musharrat Noor, Md. Momin Islam

Erschienen in: Journal of Community Health | Ausgabe 6/2020

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Abstract

Objectives

The main aim of this study was to find the prevalence of mortality among hospitalized COVID-19 infected patients and associated risk factors for death.

Methods

Three electronic databases including PubMed, Science Direct and Google Scholar were searched to identify relevant cohort studies of COVID-19 disease from January 1, 2020, to August 11, 2020. A random-effects model was used to calculate pooled prevalence rate (PR), risk ratio (RR) and 95% confidence interval (CI) for both effect measures. Cochrane chi-square test statistic Q, \({I}^{2}\), and \({\tau }^{2}\) tests were used to measure the presence of heterogeneity. Publication bias and sensitivity of the included studies were also tested.

Results

In this meta-analysis, a total of 58 studies with 122,191 patients were analyzed. The pooled prevalence rate of mortality among the hospitalized COVID-19 patients was 18.88%, 95% CI (16.46–21.30), p < 0.001. Highest mortality was found in Europe [PR 26.85%, 95% CI (19.41–34.29), p < 0.001] followed by North America [PR 21.47%, 95% CI (16.27–26.68), p < 0.001] and Asia [PR 14.83%, 95% CI (12.46- 17.21), p < 0.001]. An significant association were found between mortality among COVID-19 infected patients and older age (> 65 years vs. < 65 years) [RR 3.59, 95% CI (1.87–6.90), p < 0.001], gender (male vs. female) [RR 1.63, 95% CI (1.43–1.87), p < 0.001], ICU admitted patients [RR 3.72, 95% CI (2.70–5.13), p < 0.001], obesity [RR 2.18, 95% CI (1.10–4.34), p < 0.05], hypertension [RR 2.08,95% CI (1.79–2.43) p < 0.001], diabetes [RR 1.87, 95% CI (1.23–2.84), p < 0.001], cardiovascular disease [RR 2.51, 95% CI (1.20–5.26), p < 0.05], and cancer [RR 2.31, 95% CI (1.80–2.97), p < 0.001]. In addition, significant association for high risk of mortality were also found for cerebrovascular disease, COPD, coronary heart disease, chronic renal disease, chronic liver disease, chronic lung disease and chronic kidney disease.

Conclusion

This meta-analysis revealed that the mortality rate among COVID-19 patients was highest in the European region and older age, gender, ICU patients, patients with comorbidity had a high risk for case fatality. Those findings would help the health care providers to reduce the mortality rate and combat this pandemic to save lives using limited resources.
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Metadaten
Titel
Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis
verfasst von
Farha Musharrat Noor
Md. Momin Islam
Publikationsdatum
12.09.2020
Verlag
Springer US
Schlagwort
COVID-19
Erschienen in
Journal of Community Health / Ausgabe 6/2020
Print ISSN: 0094-5145
Elektronische ISSN: 1573-3610
DOI
https://doi.org/10.1007/s10900-020-00920-x

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