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Journal of Mammary Gland Biology and Neoplasia

Erschienen in:

01.04.2006

Probing the Microenvironment of Mammary Tumors Using Multiphoton Microscopy

verfasst von: Mazen Sidani, Jeffrey Wyckoff, Chengsen Xue, Jeffrey E. Segall, John Condeelis

Erschienen in: Journal of Mammary Gland Biology and Neoplasia | Ausgabe 2/2006

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Abstract

Advances in optical imaging technologies that allow the subcellular resolution of undissected tissue have begun to offer new clues into the biology of development and disease. For cancer, such advances mean that the primary tumor is no longer a black box and that the disease can be studied throughout the metastatic cascade and not just as an endpoint. In this review we examine the advances in multiphoton imaging technology that have been used to define the microenvironment and its role in delineating the invasion and intravasation steps of metastasis inside living mammary tumors. Results show that the tumor microenvironment is a dynamic place where interactions between tumor cells, macrophages, blood vessels, and extracellular matrix fibers define the metastatic phenotype.

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Titel: Probing the Microenvironment of Mammary Tumors Using Multiphoton Microscopy
verfasst von: Mazen Sidani
Jeffrey Wyckoff
Chengsen Xue
Jeffrey E. Segall
John Condeelis
Publikationsdatum: 01.04.2006
Verlag: Kluwer Academic Publishers-Plenum Publishers
Erschienen in: Journal of Mammary Gland Biology and Neoplasia / Ausgabe 2/2006
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-006-9021-5

Springer Medizin

Probing the Microenvironment of Mammary Tumors Using Multiphoton Microscopy

Abstract

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Springer Medizin

Abstract

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