Erschienen in:
01.03.2012
RETRACTED ARTICLE: Roles of MicroRNAs and Other Non-coding
RNAs in Breast Cancer Metastasis
verfasst von:
Scott Valastyan
Erschienen in:
Journal of Mammary Gland Biology and Neoplasia
|
Ausgabe 1/2012
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Abstract
Despite the fact that metastases are responsible for the overwhelming majority
of human cancer deaths, our comprehension of the molecular events that drive
metastatic progression remains woefully incomplete. Excitingly, the recent
appreciation that various species of non-coding RNAs—including microRNAs—play
pivotal roles in dictating the malignant behaviors of breast carcinoma cells
promises to afford new insights into the molecular circuitry that determines
metastatic propensity. Here, I summarize our current knowledge regarding these
still-emerging functions for non-coding RNAs in the pathogenesis of breast cancer
metastasis, with an emphasis placed upon the roles played by microRNAs in these
processes. Additionally, I discuss the potential translational opportunities
afforded by these research findings for the diagnosis and treatment of human breast
tumors. When assessed collectively, it is apparent that although this field of
research is still in its infancy, comprehension of the biological actions of
microRNAs and other non-coding RNAs will hold important consequences for our
understanding of the etiology of metastatic disease, as well as its clinical
management and treatment.