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Journal of Neuro-Oncology

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01.01.2011 | Case Report

Malignant ganglioglioma: case report and review of literature

verfasst von: Ryan DeMarchi, Suzy Abu-Abed, David Munoz, R. Loch Macdonald

Erschienen in: Journal of Neuro-Oncology | Ausgabe 2/2011

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Abstract

We report a case of de novo malignant ganglioglioma. A 61-year-old male presented with a 12-day history of headaches and general malaise. Pre-operative magnetic resonance imaging revealed an irregular enhancing mass in the left temporal lobe with associated dural enhancement and subacute subdural hematoma. The findings at surgery were of a vascular tumor intimately involving the surrounding white matter, with central necrosis. Histological and immunohistochemical studies showed an anaplastic ganglioglioma with World Health Organization grade IV characteristics. Gangliogliomas of the central nervous system are rare and are typified by a pediatric predilection and indolent behavior. A review of the de novo anaplastic and malignant gangliogliomas is presented.

Rumana CS, Valadka AB (1998) Radiation therapy and malignant degeneration of benign supratentorial gangliogliomas. Neurosurgery 42:1038–1043PubMedCrossRef

Luyken C, Blumcke I, Fimmers R, Urbach H, Wiestler OD, Schramm J (2004) Supratentorial gangliogliomas: histopathologic grading and tumor recurrence in 184 patients with a median follow-up of 8 years. Cancer 101:146–155PubMedCrossRef

Mclendon RE, Enterline DS, Tien RD, Thorstad WL, Bruner JM (1998) Tumors of central neuroepithelial origin. In: Bigner DD, Mclendon RE, Bruner JM (eds) Russell and Rubinstein’s pathology of tumors of the nervous system. Arnold Publishing, London, pp 308–309

Zentner J, Wolf HK, Ostertun B, Hufnagel A, Campos MG, Solymosi L, Schramm J (1994) Gangliogliomas: clinical, radiological, and histopathological findings in 51 patients. J Neurol Neurosurg Psychiatry 57:1497–1502PubMedCrossRef

Lang FF, Epstein FJ, Ransohoff J, Allen JC, Wisoff J, Abbott IR, Miller DC (1993) Central nervous system gangliogliomas. Part 2. Clinical outcome. J Neurosurg 79:867–873PubMedCrossRef

Nelson JS, Burger JM, Wiestler OD, VandenBerg SR (2000) Ganglioglioma and gangliocytoma. In: Kleihues P, Cavenee WK (eds) World Health Organization Classification of Tumours. Pathology and genetics of tumours of the nervous system. IARC Press, Lyon, pp 96–98

Blumcke I, Wiestler OD (2002) Gangliogliomas: an intriguing tumor entity associated with focal epilepsies. J Neuropathol Exp Neurol 61:575–584PubMed

Karremann M, Pietsch T, Janssen G, Kramm CM, Wolff JE (2009) Anaplastic ganglioglioma in children. J Neurooncol 92:157–163PubMedCrossRef

Kitano M, Takayama S, Nagao T, Yoshimura O (1987) Malignant ganglioglioma of the spinal cord. Acta Pathol Jpn 37:1009–1018PubMed

10.

Kawataki T, Sato E, Sato T, Kinouchi H (2010) Anaplastic ganglioglioma with malignant features in both neuronal and glial components—case report. Neurol Med Chir (Tokyo) 50:228–231CrossRef

11.

Mittelbronn M, Schittenhelm J, Lemke D, Ritz R, Nagele T, Weller M, Meyermann R, Beschorner R (2007) Low grade ganglioglioma rapidly progressing to a WHO grade IV tumor showing malignant transformation in both astroglial and neuronal cell components. Neuropathology 27:463–467PubMedCrossRef

12.

Hirose T, Kannuki S, Nishida K, Matsumoto K, Sano T, Hizawa K (1992) Anaplastic ganglioglioma of the brain stem demonstrating active neurosecretory features of neoplastic neuronal cells. Acta Neuropathol 83:365–370PubMedCrossRef

13.

Nakajima M, Kidooka M, Nakasu S (1998) Anaplastic ganglioglioma with dissemination to the spinal cord: a case report. Surg Neurol 49:445–448PubMedCrossRef

14.

Allegranza A, Pileri S, Frank G, Ferracini R (1990) Cerebral ganglioglioma with anaplastic oligodendroglial component. Histopathology 17:439–441PubMedCrossRef

15.

Chau HL, Chan CM, Pong WM, Tan TC, Cheung JY, Chan SC (2001) Coexistence of malignant meningioma and anaplastic ganglioglioma. J Hong Kong Coll Radiol 4:297–301

16.

Suzuki H, Otsuki T, Iwasaki Y, Katakura R, Asano H, Tadokoro M, Suzuki Y, Tezuka F, Takei H (2002) Anaplastic ganglioglioma with sarcomatous component: an immunohistochemical study and molecular analysis of p53 tumor suppressor gene. Neuropathology 22:40–47PubMedCrossRef

17.

David KM, de Sanctis S, Lewis PD, Noury AM, Edwards JM (2000) Neuroblastomatous recurrence of ganglioglioma. Case report. J Neurosurg 93:698–700PubMedCrossRef

18.

Wolf HK, Muller MB, Spanle M, Zentner J, Schramm J, Wiestler OD (1994) Ganglioglioma: a detailed histopathological and immunohistochemical analysis of 61 cases. Acta Neuropathol 88:166–173PubMedCrossRef

19.

Isimbaldi G, Sironi M, Tonnarelli GP, Roncoroni M, Declich P, Galli C (1996) Ganglioglioma: a clinical and pathological study of 12 cases. Clin Neuropathol 15:192–199PubMed

20.

Haddad SF, Moore SA, Menezes AH, VanGilder JC (1992) Ganglioglioma: 13 years of experience. Neurosurgery 31:171–178PubMedCrossRef

21.

Prayson RA, Khajavi K, Comair YG (1995) Cortical architectural abnormalities and MIB1 immunoreactivity in gangliogliomas: a study of 60 patients with intracranial tumors. J Neuropathol Exp Neurol 54:513–520PubMedCrossRef

22.

Hakim R, Loeffler JS, Anthony DC, Black PM (1997) Gangliogliomas in adults. Cancer 79:127–131PubMedCrossRef

23.

Rodewald L, Miller DC, Sciorra L, Barabas G, Lee ML (1987) Central nervous system neoplasm in a young man with Martin-Bell syndrome—fra(X)-XLMR. Am J Med Genet 26:7–12PubMedCrossRef

24.

Araki M, Fan J, Haraoka S, Moritake T, Yoshii Y, Watanabe T (1999) Extracranial metastasis of anaplastic ganglioglioma through a ventriculoperitoneal shunt: a case report. Pathol Int 49:258–263PubMedCrossRef

25.

Campos MG, Zentner J, Ostertun B, Wolf HK, Schramm J (1994) Anaplastic ganglioglioma: case report and review of the literature. Neurol Res 16:317–320PubMed

26.

Danjoux M, Sabatier J, Uro-Coste E, Roche H, Delisle MB (2001) Anaplastic temporal ganglioglioma with spinal metastasis. Ann Pathol 21:55–58PubMed

27.

Dash RC, Provenzale JM, McComb RD, Perry DA, Longee DC, Mclendon RE (1999) Malignant supratentorial ganglioglioma (ganglion cell-giant cell glioblastoma): a case report and review of the literature. Arch Pathol Lab Med 123:342–345PubMed

28.

Hall WA, Yunis EJ, Albright AL (1986) Anaplastic ganglioglioma in an infant: case report and review of the literature. Neurosurgery 19:1016–1020PubMedCrossRef

29.

Mekni A, Chelly I, Haouet S, Zitouna M, Kchir N (2006) Malignant cerebellar ganglioglioma. A case report and review of the literature. Neurochirurgie 52:119–122PubMedCrossRef

30.

Karabekir HS, Balci C, Tokyol C (2006) Primary spinal anaplastic ganglioglioma. Pediatr Neurosurg 42:374–378PubMedCrossRef

31.

Kang DH, Lee CH, Hwang SH, Park IS, Han JW, Jung JM (2007) Anaplastic ganglioglioma in a middle-aged woman: a case report with a review of the literature. J Korean Med Sci 22(Suppl):S139–S144PubMedCrossRef

32.

Matsuzaki K, Uno M, Kageji T, Hirose T, Nagahiro S (2005) Anaplastic ganglioglioma of the cerebellopontine angle. Case report. Neurol Med Chir (Tokyo) 45:591–595CrossRef

33.

Nair V, Suri VS, Tatke M, Saran RK, Malhotra V, Singh D (2004) Gangliogliomas: a report of five cases. Indian J Cancer 41:41–46PubMed

34.

Schittenhelm J, Reifenberger G, Ritz R, Nagele T, Weller M, Pantazis G, Capper D, Beschorner R, Meyermann R, Mittelbronn M (2008) Primary anaplastic ganglioglioma with a small-cell glioblastoma component. Clin Neuropathol 27:91–95PubMed

35.

Rogojan L, Olinici CD (2008) Ganglioglioma with glioblastoma component. Rom J Morphol Embryol 49:403–406PubMed

36.

Wacker MR, Cogen PH, Etzell JE, Daneshvar L, Davis RL, Prados MD (1992) Diffuse leptomeningeal involvement by a ganglioglioma in a child. case report. J Neurosurg 77:302–306PubMedCrossRef

37.

Kernohan JW, Learmonth JR, Doyle JB (1932) Neuroblastomas and gangliocytomas of the central nervous system. Brain 55:287–310CrossRef

38.

Hirose T, Scheithauer BW, Lopes MB, Gerber HA, Altermatt HJ, VandenBerg SR (1997) Ganglioglioma: an ultrastructural and immunohistochemical study. Cancer 79:989–1003PubMedCrossRef

39.

Jay V, Squire J, Becker LE, Humphreys R (1994) Malignant transformation in a ganglioglioma with anaplastic neuronal and astrocytic components. Report of a case with flow cytometric and cytogenetic analysis. Cancer 73:2862–2868PubMedCrossRef

40.

Im SH, Chung CK, Cho BK, Wang KC, Yu IK, Song IC, Cheon GJ, Lee DS, Kim NR, Chi JG (2002) Intracranial ganglioglioma: preoperative characteristics and oncologic outcome after surgery. J Neurooncol 59:173–183PubMedCrossRef

41.

Siddique K, Zagardo M, Gujrati M, Olivero W (2002) Ganglioglioma presenting as a meningioma: case report and review of the literature. Neurosurgery 50:1133–1135PubMedCrossRef

42.

Selch MT, Goy BW, Lee SP, El-Sadin S, Kincaid P, Park SH, Withers HR (1998) Gangliogliomas: experience with 34 patients and review of the literature. Am J Clin Oncol 21:557–564PubMedCrossRef

43.

Liauw SL, Byer JE, Yachnis AT, Amdur RJ, Mendenhall WM (2007) Radiotherapy after subtotally resected or recurrent ganglioglioma. Int J Radiat Oncol Biol Phys 67:244–247PubMedCrossRef

Titel: Malignant ganglioglioma: case report and review of literature
verfasst von: Ryan DeMarchi
Suzy Abu-Abed
David Munoz
R. Loch Macdonald
Publikationsdatum: 01.01.2011
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 2/2011
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-010-0248-z

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Malignant ganglioglioma: case report and review of literature

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