Skip to main content
Erschienen in: International Journal of Clinical Pharmacy 5/2014

01.10.2014 | Research Article

Drug-related problems and the clinical role of pharmacists in inpatient mental health: an insight into practice in Australia

verfasst von: Tom E. Richardson, Claire L. O’Reilly, Timothy F. Chen

Erschienen in: International Journal of Clinical Pharmacy | Ausgabe 5/2014

Einloggen, um Zugang zu erhalten

Abstract

Background Drug-related problems (DRPs) cause significant morbidity and mortality in healthcare. Clinical pharmacists have shown to reduce DRPs in the inpatient setting. In mental health the effects of clinical pharmacists on DRPs is relatively unknown. Objective To explore the clinical role of inpatient mental health pharmacists and the factors affecting their role. Setting Australian hospitals. Method Mixed methods. As the profile of the hospital mental health pharmacy workforce is unknown, surveys were distributed to all Australian hospitals with a pharmacy department. DRPs and recommendations were classified using an adaptation of the DOCUMENT system. In-depth semi-structured interviews were undertaken with members of the Society of Hospital Pharmacists Australia’s Mental Health Committee of Specialty Practice. Main outcome measures Types of DRPs identified by mental health pharmacists, the recommendations made to address them and the rate at which these recommendations were implemented. As well as mental health pharmacists’ views on the factors which affect their clinical role. Results 277 clinical interventions were reported by 47 mental health pharmacists, with 332 DRPs identified and 355 recommendations made. Drug interactions were the most commonly identified DRP (13.9 %). DRPs ranged in severity and likelihood of occurring. Changes to therapy accounted for the vast majority of recommendations (60.8 %), with the most common being change of drug (29.9 %). In total 91.8 % of recommendations were implemented. On average pharmacists estimated 56.1 % of their clinical interventions focused on psychotropic medication issues. Sixteen pharmacists were interviewed. Their relationship with the medical officers, time constraints and a gap in the evidence base to guide practice were identified as the major factors affecting their role. Conclusion Pharmacists play an important role in ensuring the quality use of medicines in inpatient mental health. However, significant factors need to be addressed to further expand clinical pharmacy services in inpatient mental healthcare in Australia.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Kohn LT, Corrigan JM, Donaldson MS. To err is human: building a safer health system. Washington, DC: The National Academies Press; 2000. Kohn LT, Corrigan JM, Donaldson MS. To err is human: building a safer health system. Washington, DC: The National Academies Press; 2000.
2.
Zurück zum Zitat Kongkaew C, Noyce PR, Ashcroft DM. Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies. Ann Pharmacother. 2008;42(7–8):1017–25.PubMedCrossRef Kongkaew C, Noyce PR, Ashcroft DM. Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies. Ann Pharmacother. 2008;42(7–8):1017–25.PubMedCrossRef
3.
Zurück zum Zitat Miguel A, Azevedo LF, Araujo M, Pereira AC. Frequency of adverse drug reactions in hospitalized patients: a systematic review and meta-analysis. Pharmacoepidemiol Drug Saf. 2012;21(11):1139–54.PubMedCrossRef Miguel A, Azevedo LF, Araujo M, Pereira AC. Frequency of adverse drug reactions in hospitalized patients: a systematic review and meta-analysis. Pharmacoepidemiol Drug Saf. 2012;21(11):1139–54.PubMedCrossRef
4.
Zurück zum Zitat de Vries EN, Ramrattan MA, Smorenburg SM, Gouma DJ, Boermeester MA. The incidence and nature of in-hospital adverse events: a systematic review. Qual Saf Health Care. 2008;17(3):216–23.PubMedPubMedCentralCrossRef de Vries EN, Ramrattan MA, Smorenburg SM, Gouma DJ, Boermeester MA. The incidence and nature of in-hospital adverse events: a systematic review. Qual Saf Health Care. 2008;17(3):216–23.PubMedPubMedCentralCrossRef
5.
Zurück zum Zitat Bates DW, Spell N, Cullen DJ, et al. The costs of adverse drug events in hospitalized patients. JAMA. 1997;277(4):307–11.PubMedCrossRef Bates DW, Spell N, Cullen DJ, et al. The costs of adverse drug events in hospitalized patients. JAMA. 1997;277(4):307–11.PubMedCrossRef
6.
Zurück zum Zitat Endicott J, Spitzer RL, Fleiss JL, Cohen J. The global assessment scale: a procedure for measuring overall severity of psychiatric disturbance. Arch Gen Psychiatry. 1976;33(6):766–71.PubMedCrossRef Endicott J, Spitzer RL, Fleiss JL, Cohen J. The global assessment scale: a procedure for measuring overall severity of psychiatric disturbance. Arch Gen Psychiatry. 1976;33(6):766–71.PubMedCrossRef
7.
Zurück zum Zitat Lawrence D, Hancock KJ, Kisely S. The gap in life expectancy from preventable physical illness in psychiatric patients in Western Australia: retrospective analysis of population based registers. BMJ. 2013;346:f2539. Lawrence D, Hancock KJ, Kisely S. The gap in life expectancy from preventable physical illness in psychiatric patients in Western Australia: retrospective analysis of population based registers. BMJ. 2013;346:f2539.
8.
Zurück zum Zitat Grohmann R, Hippius H, Helmchen H, Ruther E, Schmidt LG. The AMUP study for drug surveillance in psychiatry: a summary of inpatient data. Pharmacopsychiatry. 2004;37(1):S16–26.PubMed Grohmann R, Hippius H, Helmchen H, Ruther E, Schmidt LG. The AMUP study for drug surveillance in psychiatry: a summary of inpatient data. Pharmacopsychiatry. 2004;37(1):S16–26.PubMed
9.
Zurück zum Zitat Degner D, Grohmann R, Kropp S, Rüther E, Bender S, Engel RR, et al. Severe adverse drug reactions of antidepressants: results of the German Multicenter Drug Surveillance Program AMSP. Pharmacopsychiatry. 2004;37(1):39–45. Degner D, Grohmann R, Kropp S, Rüther E, Bender S, Engel RR, et al. Severe adverse drug reactions of antidepressants: results of the German Multicenter Drug Surveillance Program AMSP. Pharmacopsychiatry. 2004;37(1):39–45.
10.
Zurück zum Zitat Leape LL, Cullen DJ, Clapp M, et al. Pharmacist participation on physician rounds and adverse drug events in the intensive care unit. JAMA. 1999;282(3):267–70.PubMedCrossRef Leape LL, Cullen DJ, Clapp M, et al. Pharmacist participation on physician rounds and adverse drug events in the intensive care unit. JAMA. 1999;282(3):267–70.PubMedCrossRef
11.
Zurück zum Zitat Kaboli PJ, Hoth AB, McClimon BJ, Schnipper JL. Clinical pharmacists and inpatient medical care: a systematic review. Arch Intern Med. 2006;166(9):955–64.PubMedCrossRef Kaboli PJ, Hoth AB, McClimon BJ, Schnipper JL. Clinical pharmacists and inpatient medical care: a systematic review. Arch Intern Med. 2006;166(9):955–64.PubMedCrossRef
12.
Zurück zum Zitat Kucukarslan SN, Peters M, Mlynarek M, Nafziger DA. Pharmacists on rounding teams reduce preventable adverse drug events in hospital general medicine units. Arch Intern Med. 2003;163(17):2014–8.PubMedCrossRef Kucukarslan SN, Peters M, Mlynarek M, Nafziger DA. Pharmacists on rounding teams reduce preventable adverse drug events in hospital general medicine units. Arch Intern Med. 2003;163(17):2014–8.PubMedCrossRef
13.
Zurück zum Zitat Dooley MJ, Allen KM, Doecke CJ, Galbraith KJ, Taylor GR, Bright J, et al. A prospective multicentre study of pharmacist initiated changes to drug therapy and patient management in acute care government funded hospitals. Br J Clin Pharmacol. 2004;57(4):513–21.PubMedPubMedCentralCrossRef Dooley MJ, Allen KM, Doecke CJ, Galbraith KJ, Taylor GR, Bright J, et al. A prospective multicentre study of pharmacist initiated changes to drug therapy and patient management in acute care government funded hospitals. Br J Clin Pharmacol. 2004;57(4):513–21.PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Pickard AS, Hung S-Y. An update on evidence of clinical pharmacy services’ impact on health-related quality of life. Ann Pharmacother. 2006;40(9):1623–34.PubMedCrossRef Pickard AS, Hung S-Y. An update on evidence of clinical pharmacy services’ impact on health-related quality of life. Ann Pharmacother. 2006;40(9):1623–34.PubMedCrossRef
15.
Zurück zum Zitat Altowaijri A, Phillips CJ, Fitzsimmons D. A systematic review of the clinical and economic effectiveness of clinical pharmacist intervention in secondary prevention of cardiovascular disease. J Manag Care Pharm. 2013;19(5):408–16.PubMed Altowaijri A, Phillips CJ, Fitzsimmons D. A systematic review of the clinical and economic effectiveness of clinical pharmacist intervention in secondary prevention of cardiovascular disease. J Manag Care Pharm. 2013;19(5):408–16.PubMed
16.
Zurück zum Zitat Richardson TE, O’Reilly CL, Chen TF. A comprehensive review of the impact of clinical pharmacy services on patient outcomes in mental health. Int J Clin Pharm. 2014;36(2):222–32.PubMedCrossRef Richardson TE, O’Reilly CL, Chen TF. A comprehensive review of the impact of clinical pharmacy services on patient outcomes in mental health. Int J Clin Pharm. 2014;36(2):222–32.PubMedCrossRef
17.
Zurück zum Zitat Brown S, Barraclough B, Inskip H. Causes of the excess mortality of schizophrenia. Br J Psychiatry. 2000;177(3):212–7.PubMedCrossRef Brown S, Barraclough B, Inskip H. Causes of the excess mortality of schizophrenia. Br J Psychiatry. 2000;177(3):212–7.PubMedCrossRef
18.
Zurück zum Zitat Tiihonen J, Lönnqvist J, Wahlbeck K, Klaukka T, Niskanen L, Tanskanen A, et al. 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study). The Lancet. 2009;374(9690):620–7.CrossRef Tiihonen J, Lönnqvist J, Wahlbeck K, Klaukka T, Niskanen L, Tanskanen A, et al. 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study). The Lancet. 2009;374(9690):620–7.CrossRef
21.
Zurück zum Zitat SHPA Committee of Specialty Practice in Mental Health Pharmacy. Standards of practice for mental health pharmacy. J Pharm Pract Res. 2012;42(2):142–5. SHPA Committee of Specialty Practice in Mental Health Pharmacy. Standards of practice for mental health pharmacy. J Pharm Pract Res. 2012;42(2):142–5.
22.
Zurück zum Zitat Doessel DP, Scheurer RW, Chant DC, Whiteford HA. Australia’s national mental health strategy and deinstitutionalization: some empirical results. Aust N Z J Psychiatry. 2005;39(11–12):989–94.PubMedCrossRef Doessel DP, Scheurer RW, Chant DC, Whiteford HA. Australia’s national mental health strategy and deinstitutionalization: some empirical results. Aust N Z J Psychiatry. 2005;39(11–12):989–94.PubMedCrossRef
23.
Zurück zum Zitat Department of Health and Ageing. National mental health report 2010: summary of 15 years of reform in Australia’s mental health services under the National Mental Health Strategy 1993–2008. Canberra: Commonwealth of Australia; 2010. Department of Health and Ageing. National mental health report 2010: summary of 15 years of reform in Australia’s mental health services under the National Mental Health Strategy 1993–2008. Canberra: Commonwealth of Australia; 2010.
24.
Zurück zum Zitat Alderman CP. A prospective analysis of clinical pharmacy interventions on an acute psychiatric inpatient unit. J Clin Pharm Ther. 1997;22(1):27–31.PubMedCrossRef Alderman CP. A prospective analysis of clinical pharmacy interventions on an acute psychiatric inpatient unit. J Clin Pharm Ther. 1997;22(1):27–31.PubMedCrossRef
26.
Zurück zum Zitat Society of Hospital Pharmacists Australia. Directory of Hospital Pharmacy. Melbourne; 2011. Society of Hospital Pharmacists Australia. Directory of Hospital Pharmacy. Melbourne; 2011.
27.
Zurück zum Zitat SHPA Committee of Specialty Practice in Clinical Pharmacy. Standards of practice for clinical pharmacy services. J Pharm Pract Res. 2013;43(2)(suppl):44. SHPA Committee of Specialty Practice in Clinical Pharmacy. Standards of practice for clinical pharmacy services. J Pharm Pract Res. 2013;43(2)(suppl):44.
28.
Zurück zum Zitat Virani A, Crown N. The impact of a clinical pharmacist on patient and economic outcomes in a child and adolescent mental health unit. Can J Hosp Pharm. 2003;56(3):158–62. Virani A, Crown N. The impact of a clinical pharmacist on patient and economic outcomes in a child and adolescent mental health unit. Can J Hosp Pharm. 2003;56(3):158–62.
29.
Zurück zum Zitat Marino J, Caballero J, Llosent M, Hinkes R. Differences in pharmacy interventions at a psychiatric hospital: comparison of staff pharmacists, pharmacy faculty, and student pharmacists. Hosp Pharm. 2010;45(4):314–9.CrossRef Marino J, Caballero J, Llosent M, Hinkes R. Differences in pharmacy interventions at a psychiatric hospital: comparison of staff pharmacists, pharmacy faculty, and student pharmacists. Hosp Pharm. 2010;45(4):314–9.CrossRef
30.
Zurück zum Zitat Campbell AR, Nelson LA, Elliott E, Hieber R, Sommi RW. Analysis of cost avoidance from pharmacy students’ clinical interventions at a psychiatric hospital. Am J Pharm Educ. 2011;75(1):8. Campbell AR, Nelson LA, Elliott E, Hieber R, Sommi RW. Analysis of cost avoidance from pharmacy students’ clinical interventions at a psychiatric hospital. Am J Pharm Educ. 2011;75(1):8.
31.
Zurück zum Zitat Stoner SC, Worrel JA, Jones MT, Farrar CA, Ramlatchman LV. Pharmacist-designed and -implemented pharmaceutical care plan for antipsychotic-induced movement disorders. Pharmacotherapy. 2000;20(5):583–8.PubMedCrossRef Stoner SC, Worrel JA, Jones MT, Farrar CA, Ramlatchman LV. Pharmacist-designed and -implemented pharmaceutical care plan for antipsychotic-induced movement disorders. Pharmacotherapy. 2000;20(5):583–8.PubMedCrossRef
32.
Zurück zum Zitat Dorevitch A, Perl E. The impact of clinical pharmacy intervention in a psychiatric inpatient hospital. J Clin Pharm Ther. 1996;21:45–8.PubMedCrossRef Dorevitch A, Perl E. The impact of clinical pharmacy intervention in a psychiatric inpatient hospital. J Clin Pharm Ther. 1996;21:45–8.PubMedCrossRef
33.
Zurück zum Zitat Suehs BT, Mican LM, Campbell AH. Retrospective evaluation of an inpatient psychiatric pharmacist consultation service. J Am Pharm Assoc (2003). 2011;51(5):599–604. Suehs BT, Mican LM, Campbell AH. Retrospective evaluation of an inpatient psychiatric pharmacist consultation service. J Am Pharm Assoc (2003). 2011;51(5):599–604.
34.
Zurück zum Zitat Baker R, Camosso-Stefinovic J, Gillies C, Shaw EJ, Cheater F, Flottorp S, et al. Tailored interventions to overcome identified barriers to change: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2010;3(3):CD005470. Baker R, Camosso-Stefinovic J, Gillies C, Shaw EJ, Cheater F, Flottorp S, et al. Tailored interventions to overcome identified barriers to change: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2010;3(3):CD005470.
35.
Zurück zum Zitat Makowsky MJ, Schindel TJ, Rosenthal M, Campbell K, Tsuyuki RT, Madill HM. Collaboration between pharmacists, physicians and nurse practitioners: a qualitative investigation of working relationships in the inpatient medical setting. J Interprof Care. 2009;23(2):169–84.PubMedCrossRef Makowsky MJ, Schindel TJ, Rosenthal M, Campbell K, Tsuyuki RT, Madill HM. Collaboration between pharmacists, physicians and nurse practitioners: a qualitative investigation of working relationships in the inpatient medical setting. J Interprof Care. 2009;23(2):169–84.PubMedCrossRef
36.
Zurück zum Zitat Australian Institute of Health and Welfare. Medical workforce 2011. National Health Workforce series no. 3. Canberra; 2013. Australian Institute of Health and Welfare. Medical workforce 2011. National Health Workforce series no. 3. Canberra; 2013.
37.
Zurück zum Zitat Stratford J. How does Australia train its psychiatrists? Psychiatr Bull. 2002;26(2):73–4.CrossRef Stratford J. How does Australia train its psychiatrists? Psychiatr Bull. 2002;26(2):73–4.CrossRef
38.
Zurück zum Zitat De Hert M, Cohen D, Bobes J, Cetkovich-Bakmas M, Leucht S, Ndetei DM, et al. Physical illness in patients with severe mental disorders. II. Barriers to care, monitoring and treatment guidelines, plus recommendations at the system and individual level. World Psychiatry. 2011;10(2):138–51.PubMed De Hert M, Cohen D, Bobes J, Cetkovich-Bakmas M, Leucht S, Ndetei DM, et al. Physical illness in patients with severe mental disorders. II. Barriers to care, monitoring and treatment guidelines, plus recommendations at the system and individual level. World Psychiatry. 2011;10(2):138–51.PubMed
39.
Zurück zum Zitat Millar H. Management of physical health in schizophrenia: a stepping stone to treatment success. Eur Neuropsychopharmacol. 2008;18(2):121–8.CrossRef Millar H. Management of physical health in schizophrenia: a stepping stone to treatment success. Eur Neuropsychopharmacol. 2008;18(2):121–8.CrossRef
40.
Zurück zum Zitat Parks J, Svendsen D, Singer P, Foti ME, Mauer B. Morbidity and mortality in people with serious mental illness: National Association of State Mental Health Program Directors (NASMHPD) Medical Directors Council Alexandria, VA; 2006. Parks J, Svendsen D, Singer P, Foti ME, Mauer B. Morbidity and mortality in people with serious mental illness: National Association of State Mental Health Program Directors (NASMHPD) Medical Directors Council Alexandria, VA; 2006.
41.
Zurück zum Zitat Hetrick SE, Simmons M, Thompson A, Parker AG. What are specialist mental health clinician attitudes to guideline recommendations for the treatment of depression in young people? Aust N Z J Psychiatry. 2011;45(11):993–1001.PubMedCrossRef Hetrick SE, Simmons M, Thompson A, Parker AG. What are specialist mental health clinician attitudes to guideline recommendations for the treatment of depression in young people? Aust N Z J Psychiatry. 2011;45(11):993–1001.PubMedCrossRef
42.
Zurück zum Zitat Lehman AF, Steinwachs DM, Project TSC-IotP. Patterns of usual care for schizophrenia: initial results from the schizophrenia patient outcomes research team (PORT) client survey. Schizophr Bull. 1998;24(1):11–20.PubMedCrossRef Lehman AF, Steinwachs DM, Project TSC-IotP. Patterns of usual care for schizophrenia: initial results from the schizophrenia patient outcomes research team (PORT) client survey. Schizophr Bull. 1998;24(1):11–20.PubMedCrossRef
43.
Zurück zum Zitat Grimshaw JM, Thomas RE, MacLennan G, Fraser C, Ramsay CR, Vale L, et al. Effectiveness and efficiency of guideline dissemination and implementation strategies. Health Technol Assess. 2004;8(6):1–72. Grimshaw JM, Thomas RE, MacLennan G, Fraser C, Ramsay CR, Vale L, et al. Effectiveness and efficiency of guideline dissemination and implementation strategies. Health Technol Assess. 2004;8(6):1–72.
44.
Zurück zum Zitat Advanced Practice Framework Steering Committee. An advanced pharmacy practice framework for Australia—October 2012. Canberra; 2012. Advanced Practice Framework Steering Committee. An advanced pharmacy practice framework for Australia—October 2012. Canberra; 2012.
45.
Zurück zum Zitat Williams M, Peterson G, Tenni P, Bindoff I, Stafford A. DOCUMENT: a system for classifying drug-related problems in community pharmacy. Int J Clin Pharm. 2012;34(1):43–52.PubMedCrossRef Williams M, Peterson G, Tenni P, Bindoff I, Stafford A. DOCUMENT: a system for classifying drug-related problems in community pharmacy. Int J Clin Pharm. 2012;34(1):43–52.PubMedCrossRef
Metadaten
Titel
Drug-related problems and the clinical role of pharmacists in inpatient mental health: an insight into practice in Australia
verfasst von
Tom E. Richardson
Claire L. O’Reilly
Timothy F. Chen
Publikationsdatum
01.10.2014
Verlag
Springer Netherlands
Erschienen in
International Journal of Clinical Pharmacy / Ausgabe 5/2014
Print ISSN: 2210-7703
Elektronische ISSN: 2210-7711
DOI
https://doi.org/10.1007/s11096-014-9997-7

Weitere Artikel der Ausgabe 5/2014

International Journal of Clinical Pharmacy 5/2014 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.