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Pituitary
Erschienen in: Pituitary 1/2013

01.03.2013

Mortality and morbidity in adult craniopharyngioma

verfasst von: Eva Marie Erfurth, Helene Holmer, Sigridur Bara Fjalldal

Erschienen in: Pituitary | Ausgabe 1/2013

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Abstract

A craniopharyngioma (CP) is an embryonic malformation of the sellar and parasellar region. The annual incidence is 0.5–2.0 cases/million/year and approximately 60 % of CP are seen in adulthood. Craniopharyngiomas have the highest mortality of all pituitary tumors. Typical initial manifestations at diagnosis in adults are visual disturbances, hypopituitarism and symptoms of elevated intracranial pressure. The long-term morbidity is substantial with hypopituitarism, increased cardiovascular risk, hypothalamic damage, visual and neurological deficits, reduced bone health, and reduction in quality of life and cognitive function. Therapy of choice is surgery, followed by cranial radiotherapy in about half of the patients. The standardised overall mortality rate varies 2.88–9.28 in cohort studies. Patients with CP have a 3–19 fold higher cardiovascular mortality in comparison to the general population. Women with CP have an even higher risk.
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Metadaten
Titel
Mortality and morbidity in adult craniopharyngioma
verfasst von
Eva Marie Erfurth
Helene Holmer
Sigridur Bara Fjalldal
Publikationsdatum
01.03.2013
Verlag
Springer US
Erschienen in
Pituitary / Ausgabe 1/2013
Print ISSN: 1386-341X
Elektronische ISSN: 1573-7403
DOI
https://doi.org/10.1007/s11102-012-0428-2

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