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01.08.2013 | Review

Biological pathways and genetic mechanisms involved in social functioning

verfasst von: Juan R. Ordoñana, Meike Bartels, Dorret I. Boomsma, David Cella, Miriam Mosing, Joao R. Oliveira, Donald L. Patrick, Ruut Veenhoven, Gert G. Wagner, Mirjam A.G. Sprangers, The GENEQOL Consortium

Erschienen in: Quality of Life Research | Ausgabe 6/2013

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Abstract

Purpose

Methods

A search of Web of Science and PubMed databases was conducted using combinations of the following keywords: genetics, twins, heritability, social functioning, social adjustment, social interaction, and social dysfunction.

Results

Variability in the definitions and measures of social functioning was extensive. Moderate to high heritability was reported for social functioning and related concepts, including prosocial behavior, loneliness, and extraversion. Disorders characterized by impairments in social functioning also show substantial heritability. Genetic variants hypothesized to be involved in social functioning are related to the network of brain structures and processes that are known to affect social cognition and behavior.

Conclusions

Better knowledge and understanding about the impact of genetic factors on social functioning is needed to help us to attain a more comprehensive view of health-related quality-of-life (HRQOL) and will ultimately enhance our ability to identify those patients who are vulnerable to poor social functioning.

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Titel: Biological pathways and genetic mechanisms involved in social functioning
verfasst von: Juan R. Ordoñana
Meike Bartels
Dorret I. Boomsma
David Cella
Miriam Mosing
Joao R. Oliveira
Donald L. Patrick
Ruut Veenhoven
Gert G. Wagner
Mirjam A.G. Sprangers
The GENEQOL Consortium
Publikationsdatum: 01.08.2013
Verlag: Springer Netherlands
Erschienen in: Quality of Life Research / Ausgabe 6/2013
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-012-0277-5

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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