Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Reviews in Endocrine and Metabolic Disorders
Erschienen in: Reviews in Endocrine and Metabolic Disorders 4/2009

01.12.2009

Role of biological rhythms in gastrointestinal health and disease

verfasst von: Willemijntje A. Hoogerwerf

Erschienen in: Reviews in Endocrine and Metabolic Disorders | Ausgabe 4/2009

Einloggen, um Zugang zu erhalten

Abstract

The molecular basis for biological rhythms is formed by clock genes. Clock genes are functional in the liver, within gastrointestinal epithelial cells and neurons of the enteric nervous system. These observations suggest a possible role for clock genes in various circadian functions of the liver and the gastrointestinal tract through the modulation of organ specific clock-controlled genes. Consequently, disruptions in circadian rhythmicity may lead to adverse health consequences. This review will focus on the current understanding of the role of circadian rhythms in the pathogenesis of gastrointestinal- and hepatic disease such as obesity, non-alcoholic fatty liver disease, alcoholic fatty liver disease and alterations in colonic motility.
Literatur
1.
Brown SA, Schibler U. The ins and outs of circadian timekeeping. Curr Opin Genet Dev. 1999;9:588–94.CrossRefPubMed
2.
Bell-Pedersen D, Cassone VM, Earnest DJ, Golden SS, Hardin PE, Thomas TL, et al. Circadian rhythms from multiple oscillators: lessons from diverse organisms. Nat Rev Genet. 2005;6:544–56.CrossRefPubMed
3.
Lowrey PL, Takahashi JS. Mammalian circadian biology: elucidating genome-wide levels of temporal organization. Annu Rev Genomics Hum Genet. 2004;5:407–41.CrossRefPubMed
4.
Siepka SM, Yoo SH, Park J, Lee C, Takahashi JS. Genetics and neurobiology of circadian clocks in mammals. Cold Spring Harb Symp Quant Biol. 2007;72:251–9.CrossRefPubMed
5.
6.
Halberg F, Haus E, Cornelissen G. From Biologic rhythms to chronomes relevant for nutrition. In: Marriott B, editor. Not eating enough: Overcoming underconsumption of military operational rations. Washington, DC: National Academy; 1995. p. 361–72.
7.
Hirsch E, Halberg E, Halberg F, Goetz FC, Cressey D, Wendt H, et al. Body weight change during 1 week on a single daily 2, 000-calorie meal consumed as breakfast (B) or dinner (D). Chronobiologia. 1975;2:31–2.
8.
Karlsson B, Knutsson A, Lindahl B. Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27,485 people. Occup Environ Med. 2001;58:747–52.CrossRefPubMed
9.
Morikawa Y, Nakagawa H, Miura K, Soyama Y, Ishizaki M, Kido T, et al. Effect of shift work on body mass index and metabolic parameters. Scand J Work Environ Health. 2007;33:45–50.PubMed
10.
Dallman MF, Engeland WC, Rose JC, Wilkinson CW, Shinsako J, Siedenburg F. Nycthemeral rhythm in adrenal responsiveness to ACTH. Am J Physiol. 1978;235:R210–8.PubMed
11.
Dallman MF, Strack AM, Akana SF, Bradbury MJ, Hanson ES, Scribner KA, et al. Feast and famine: critical role of glucocorticoids with insulin in daily energy flow. Front Neuroendocrinol. 1993;14:303–47.CrossRefPubMed
12.
Jasper MS, Engeland WC. Splanchnic neural activity modulates ultradian and circadian rhythms in adrenocortical secretion in awake rats. Neuroendocrinology. 1994;59:97–109.CrossRefPubMed
13.
Moore RY, Eichler VB. Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat. Brain Res. 1972;42:201–6.CrossRefPubMed
14.
Nagai K, Nishio T, Nakagawa H, Nakamura S, Fukuda Y. Effect of bilateral lesions of the suprachiasmatic nuclei on the circadian rhythm of food-intake. Brain Res. 1978;142:384–9.CrossRefPubMed
15.
Tataranni PA, Larson DE, Snitker S, Young JB, Flatt JP, Ravussin E. Effects of glucocorticoids on energy metabolism and food intake in humans. Am J Physiol. 1996;271:E317–25.PubMed
16.
17.
Koska J, de Courten B, Wake DJ, Nair S, Walker BR, Bunt JC, et al. 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue and prospective changes in body weight and insulin resistance. Obesity (Silver Spring). 2006;14:1515–22.CrossRef
18.
Livingstone DE, Jones GC, Smith K, Jamieson PM, Andrew R, Kenyon CJ, et al. Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology. 2000;141:560–3.CrossRefPubMed
19.
Livingstone DE, Kenyon CJ, Walker BR. Mechanisms of dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in obese Zucker rats. J Endocrinol. 2000;167:533–9.CrossRefPubMed
20.
Dallman MF, Pecoraro N, Akana SF, La Fleur SE, Gomez F, Houshyar H, et al. Chronic stress and obesity: a new view of “comfort food”. Proc Natl Acad Sci USA. 2003;100:11696–701.CrossRefPubMed
21.
Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci USA. 2009;106:4453–8.CrossRefPubMed
22.
Byrne CD, Olufadi R, Bruce KD, Cagampang FR, Ahmed MH. Metabolic disturbances in non-alcoholic fatty liver disease. Clin Sci (Lond). 2009;116:539–64.CrossRef
23.
Vuppalanchi R, Chalasani N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. Hepatology. 2009;49:306–17.CrossRefPubMed
24.
Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest. 2008;118:829–38.CrossRefPubMed
25.
Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, et al. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 2002;109:307–20.CrossRefPubMed
26.
Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, Wong WH, et al. Extensive and divergent circadian gene expression in liver and heart. Nature. 2002;417:78–83.CrossRefPubMed
27.
Yang X, Downes M, Yu RT, Bookout AL, He W, Straume M, et al. Nuclear receptor expression links the circadian clock to metabolism. Cell. 2006;126:801–10.CrossRefPubMed
28.
Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, McDearmon E, et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science. 2005;308:1043–5.CrossRefPubMed
29.
Ando H, Yanagihara H, Hayashi Y, Obi Y, Tsuruoka S, Takamura T, et al. Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue. Endocrinology. 2005;146:5631–6.CrossRefPubMed
30.
Fontaine C, Dubois G, Duguay Y, Helledie T, Vu-Dac N, Gervois P, et al. The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation. J Biol Chem. 2003;278:37672–80.CrossRefPubMed
31.
Ando H, Takamura T, Matsuzawa-Nagata N, Shima KR, Nakamura S, Kumazaki M, et al. The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis. Biochem Biophys Res Commun. 2009;380:684–8.CrossRefPubMed
32.
Sookoian S, Castano G, Gemma C, Gianotti TF, Pirola CJ. Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver disease. World J Gastroenterol. 2007;13:4242–8.PubMed
33.
Kudo T, Tamagawa T, Shibata S. Effect of chronic ethanol exposure on the liver of Clock-mutant mice. J Circadian Rhythms. 2009;7:4.PubMed
34.
Deimling MJ, Schnell RC. Circadian rhythms in the biological response and disposition of ethanol in the mouse. J Pharmacol Exp Ther. 1980;213:1–8.PubMed
35.
Salsano F, Maly IP, Sasse D. The circadian rhythm of intra-acinar profiles of alcohol dehydrogenase activity in rat liver: a microquantitative study. Histochem J. 1990;22:395–400.CrossRefPubMed
36.
Stearns AT, Balakrishnan A, Rhoads DB, Ashley SW, Tavakkolizadeh A. Diurnal expression of the rat intestinal sodium-glucose cotransporter 1 (SGLT1) is independent of local luminal factors. Surgery. 2009;145:294–302.CrossRefPubMed
37.
Saito H, Terada T, Shimakura J, Katsura T, Inui K. Regulatory mechanism governing the diurnal rhythm of intestinal H+/peptide cotransporter 1 (PEPT1). Am J Physiol.: Gastrointest Liver Physiol. 2008;295:G395–402.CrossRef
38.
Pan X, Terada T, Okuda M, Inui K. Altered diurnal rhythm of intestinal peptide transporter by fasting and its effects on the pharmacokinetics of ceftibuten. J Pharmacol Exp Ther. 2003;307:626–32.CrossRefPubMed
39.
Tavakkolizadeh A, Ramsanahie A, Levitsky LL, Zinner MJ, Whang EE, Ashley SW, et al. Differential role of vagus nerve in maintaining diurnal gene expression rhythms in the proximal small intestine. J Surg Res. 2005;129:73–8.CrossRefPubMed
40.
Hoogerwerf WA, Hellmich HL, Cornelissen G, Halberg F, Shahinian VB, Bostwick J, et al. Clock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimen. Gastroenterology. 2007;133:1250–60.CrossRefPubMed
41.
Auwerda JJ, Bac DJ, Schouten WR. Circadian rhythm of rectal motor complexes. Dis Colon Rectum. 2001;44:1328–32.CrossRefPubMed
42.
Bassotti G, Iantorno G, Fiorella S, Bustos-Fernandez L, Bilder CR. Colonic motility in man: features in normal subjects and in patients with chronic idiopathic constipation. Am J Gastroenterol. 1999;94:1760–70.CrossRefPubMed
43.
Frexinos J, Bueno L, Fioramonti J. Diurnal changes in myoelectric spiking activity of the human colon. Gastroenterology. 1985;88:1104–10.PubMed
44.
Rao SS, Sadeghi P, Beaty J, Kavlock R, Ackerson K. Ambulatory 24-h colonic manometry in healthy humans. Am J Physiol: Gastrointest Liver Physiol. 2001;280:G629–39.
45.
Caruso CC, Lusk SL, Gillespie BW. Relationship of work schedules to gastrointestinal diagnoses, symptoms, and medication use in auto factory workers. Am J Ind Med. 2004;46:586–98.CrossRefPubMed
46.
Cassone VM, Stephan FK. Central and peripheral regulation of feeding and nutrition by the mammalian circadian clock: implications for nutrition during manned space flight. Nutrition. 2002;18:814–9.CrossRefPubMed
47.
48.
Knutsson A. Health disorders of shift workers. Occup Med (Lond). 2003;53:103–8.CrossRef
49.
Vener KJ, Szabo S, Moore JG. The effect of shift work on gastrointestinal (GI) function: a review. Chronobiologia. 1989;16:421–39.PubMed
50.
Sladek M, Rybova M, Jindrakova Z, Zemanova Z, Polidarova L, Mrnka L, et al. Insight into the circadian clock within rat colonic epithelial cells. Gastroenterology. 2007;133:1240–9.CrossRefPubMed
51.
Hoogerwerf WA, Sinha M, Conesa A, Luxon BA, Shahinian VB, Cornelissen G, et al. Transcriptional Profiling of mRNA Expression in the Mouse Distal Colon. Gastroenterology 2008.
52.
Lu WZ, Gwee KA, Ho KY. Functional bowel disorders in rotating shift nurses may be related to sleep disturbances. Eur J Gastroenterol Hepatol. 2006;18:623–7.CrossRef
53.
Nojkov BR, J. Hoogerwerf, S. Chey, WD. The Effect of Shift Work on the Prevalence and Clinical Impact of Functional Bowel Disorders in Nurses. Am J Gastroenterol 2008.
54.
Gwee KA. Irritable bowel syndrome in developing countries—a disorder of civilization or colonization? Neurogastroenterol Motil. 2005;17:317–24.CrossRefPubMed
55.
Corney RH, Stanton R. Physical symptom severity, psychological and social dysfunction in a series of outpatients with irritable bowel syndrome. J Psychosom Res. 1990;34:483–91.CrossRefPubMed
56.
Fass R, Fullerton S, Tung S, Mayer EA. Sleep disturbances in clinic patients with functional bowel disorders. Am J Gastroenterol. 2000;95:1195–2000.CrossRefPubMed
57.
Nyhlin H, Ford MJ, Eastwood J, Smith JH, Nicol EF, Elton RA, et al. Non-alimentary aspects of the irritable bowel syndrome. J Psychosom Res. 1993;37:155–62.CrossRefPubMed
58.
Goldsmith G, Levin JS. Effect of sleep quality on symptoms of irritable bowel syndrome. Dig Dis Sci. 1993;38:1809–14.CrossRefPubMed
59.
Jarrett M, Heitkemper M, Cain KC, Burr RL, Hertig V. Sleep disturbance influences gastrointestinal symptoms in women with irritable bowel syndrome. Dig Dis Sci. 2000;45:952–9.CrossRefPubMed
60.
Burioka N, Koyanagi S, Endo M, Takata M, Fukuoka Y, Miyata M, et al. Clock gene dysfunction in patients with obstructive sleep apnoea syndrome. Eur Respir J. 2008;32:105–12.CrossRefPubMed
61.
Mistlberger RE. Circadian regulation of sleep in mammals: role of the suprachiasmatic nucleus. Brain Res Brain Res Rev. 2005;49:429–54.CrossRefPubMed
62.
Lu WZ, Gwee KA, Moochhalla S, Ho KY. Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study. Aliment Pharmacol Ther. 2005;22:927–34.CrossRefPubMed
63.
Enck P, Kaiser C, Felber M, Riepl RL, Klauser A, Klosterhalfen S, et al. Circadian variation of rectal sensitivity and gastrointestinal peptides in healthy volunteers. Neurogastroenterol Motil 2008.
64.
Chang L, Sundaresh S, Elliott J, Anton PA, Baldi P, Licudine A, et al. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome. Neurogastroenterol Motil. 2009;21:149–59.CrossRefPubMed
65.
Tebbe JJ, Pasat IR, Monnikes H, Ritter M, Kobelt P, Schafer MK. Excitatory stimulation of neurons in the arcuate nucleus initiates central CRF-dependent stimulation of colonic propulsion in rats. Brain Res. 2005;1036:130–8.CrossRefPubMed
66.
Stengel A, Tache Y. Neuroendocrine control of the gut during stress: corticotropin-releasing factor signaling pathways in the spotlight. Annu Rev Physiol 2008.
67.
Gue M, Junien JL, Bueno L. Conditioned emotional response in rats enhances colonic motility through the central release of corticotropin-releasing factor. Gastroenterology. 1991;100:964–70.PubMed
68.
Chatzaki E, Crowe PD, Wang L, Million M, Tache Y, Grigoriadis DE. CRF receptor type 1 and 2 expression and anatomical distribution in the rat colon. J Neurochem. 2004;90:309–16.CrossRefPubMed
69.
Yuan PQ, Million M, Wu SV, Rivier J, Tache Y. Peripheral corticotropin releasing factor (CRF) and a novel CRF1 receptor agonist, stressin1-A activate CRF1 receptor expressing cholinergic and nitrergic myenteric neurons selectively in the colon of conscious rats. Neurogastroenterol Motil. 2007;19:923–36.CrossRefPubMed
Metadaten
Titel
Role of biological rhythms in gastrointestinal health and disease
verfasst von
Willemijntje A. Hoogerwerf
Publikationsdatum
01.12.2009
Verlag
Springer US
Erschienen in
Reviews in Endocrine and Metabolic Disorders / Ausgabe 4/2009
Print ISSN: 1389-9155
Elektronische ISSN: 1573-2606
DOI
https://doi.org/10.1007/s11154-009-9119-3

Weitere Artikel der Ausgabe 4/2009

Reviews in Endocrine and Metabolic Disorders 4/2009 Zur Ausgabe

OriginalPaper

Physiological responses of the circadian clock to acute light exposure at night

OriginalPaper

Effects of circadian disruption on the cardiometabolic system

OriginalPaper

Melatonin formation in mammals: In vivo perspectives

OriginalPaper

Role of melatonin in metabolic regulation

OriginalPaper

The role of retinal photoreceptors in the regulation of circadian rhythms

OriginalPaper

Expression of clock genes in the suprachiasmatic nucleus: Effect of environmental lighting conditions

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypotonie | Nachrichten

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 | Hypertonie | Nachrichten

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 | Nierenkarzinom | Nachrichten

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 | NSCLC | Nachrichten

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC
weitere anzeigen

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise