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01.06.2010 | Nephrology - Original Paper

Sertraline treatment is associated with an improvement in depression and health-related quality of life in chronic peritoneal dialysis patients

verfasst von: Huseyin Atalay, Yalcin Solak, Murat Biyik, Zeynep Biyik, Mehdi Yeksan, Faruk Uguz, Ibrahim Guney, Halil Zeki Tonbul, Suleyman Turk

Erschienen in: International Urology and Nephrology | Ausgabe 2/2010

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Abstract

Objectives

There is scarce data about effects of treatment of clinical depression in peritoneal dialysis (PD) population. We aimed to determine prevalence of depression, its association with health-related quality of life (HRQoL) and effects of sertraline treatment in PD patients.

Materials and methods

We included 124 PD patients who had been on PD at least for 6 months. Short Form of Medical Outcomes Study was used to evaluate HRQoL. Depression was screened by Beck Depression Inventory (BDI). Patients with a BDI score ≥17 were deemed to have depression and were referred to a psychiatrist for evaluation via Diagnostic and Statistical Manual for Mental Disorders (DSM-IV) of diagnosis of clinical depression. About 25 patients diagnosed with clinical depression agreed to receive antidepressant treatment (Sertraline hydrochloride, 50 mg/day) for a 12-week period. After the treatment, biochemical analyses and questionnaires were repeated.

Results

Thirty-two patients (25.8%) had depression. BDI score of patients were lower compared to those without depressive symptoms (23 ± 6.7 and 9.8 ± 3.0, respectively P < 0.001). Physical component scale (PCS) and mental component scale (MCS) domains of HRQoL were significantly decreased in patients with depression than in patients without depression (P < 0.001 for PCS and MCS). In bivariate analysis the BDI score was correlated inversely with the PCS and MCS (P < 0.001). Sertraline treatment improved BDI score of patients with depression (P < 0.001). HRQoL parameters also improved. No adverse effects requiring drug cessation was seen in the study group.

Conclusions

Treatment of depression with sertraline is associated with improvement of the HRQoL and symptoms related to depression.

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Titel: Sertraline treatment is associated with an improvement in depression and health-related quality of life in chronic peritoneal dialysis patients
verfasst von: Huseyin Atalay
Yalcin Solak
Murat Biyik
Zeynep Biyik
Mehdi Yeksan
Faruk Uguz
Ibrahim Guney
Halil Zeki Tonbul
Suleyman Turk
Publikationsdatum: 01.06.2010
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 2/2010
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-009-9686-y

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Abstract

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Materials and methods

Results

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