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International Urology and Nephrology
Erschienen in: International Urology and Nephrology 4/2011

01.12.2011 | Nephrology – Original Paper

Significance of serum and urine neuraminidase activity and serum and urine level of sialic acid in diabetic nephropathy

verfasst von: Jamshid Roozbeh, Ahmad Merat, Farahnaz Bodagkhan, Raha Afshariani, Hooman Yarmohammadi

Erschienen in: International Urology and Nephrology | Ausgabe 4/2011

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Abstract

Background

Prospective studies have reported associations among various markers of inflammation and the incidence of diabetes, and it has been proposed that inflammation has a causal role in the development of diabetes. The objective of this study was to investigate the significance of serum and urine neuraminidase activity (NA) and serum and urine sialic acid (SA) level in patients with Diabetic nephropathy.

Methods

In a prospective study, 190 diabetic patients with established diabetic nephropathy, 30 type 2 diabetes patients without any diabetic related nephropathy, and 36 non-diabetic patients with diagnosed nephropathy were enrolled. Two hundred and forty healthy individuals without diabetes or kidney disease were also enrolled as control group. Fasting venous blood samples and urine samples were collected and checked for serum and urine NA and SA level.

Results

In the diabetic nephropathy group, the mean value of serum and urine NA was 64.6 ± 2.6 and 11.7 ± 1.2 mU/ml, respectively, and mean values of serum and urine SA were 93.2 ± 3.6 and 17.7 ± 1.4 mg/dl, respectively. Serum and urine NA and SA levels were significantly higher in patient with diabetic nephropathy when compared to the other groups (P < 0.001).

Conclusions

Our study suggests that there is a strong association between elevated serum and urine NA and serum and urine SA levels with the presence of diabetic nephropathy in type 2 diabetic patients. Further investigations are needed on the diagnostic and prognostic significance of these two inflammatory markers.
Literatur
1.
Nayak BS, Roberts L (2006) Relationship between inflammatory markers, metabolic and anthropometric variables in the Caribbean type 2 diabetic patients with and without microvascular complications. J Inflamm (Lond) 22(3):17CrossRef
2.
Berns G, O’Kennedy R (1990) A study of N-acetylneuraminic acid in relation to its potential as a marker of tumour development. Biochem Soc Trans 18(2):333–334PubMed
3.
Taniuchi K, Chifu K, Hayashi N, Nakamachi Y, Yamaguchi N, Miyamoto Y, Doi K, Baba S, Uchida Y, Tsukada Y, Sugimori T (1981) A new enzymatic method for the determination of sialic acid in serum and its application for a marker of acute phase reactants. Kobe J Med Sci 27(3):91–102PubMed
4.
Yokoyama H, Jensen JS, Jensen T, Deckert T (1995) Serum sialic acid concentration is elevated in IDDM especially in early diabetic nephropathy. J Intern Med 237(5):519–523PubMedCrossRef
5.
Seppala R, Renlund M, Bernardini I, Tietze F, Gahl WA (1990) Renal handling of free sialic acid in normal humans and patients with Salla disease or renal disease. Lab Invest 63(2):197–203PubMed
6.
Ozben T (1991) Elevated serum and urine sialic acid levels in renal diseases. Ann Clin Biochem 28(Pt 1):44–48PubMed
7.
Tomino Y, Inoue W, Yagame M, Nomoto Y, Sakai H, Ito K, Nagaoka K, Ikeda N (1988) Measurement of sialic acid and acute phase reactant proteins in sera of patients with diabetic nephropathy. J Diabet Complications 2(4):175–178PubMedCrossRef
8.
Bhide S, Parekh AJ, Desai MP (1998) Sialic acid levels in serum and CSF in infections and non-infections conditions. Biochem Med 18:99–101CrossRef
9.
Shamberger RJ (1984) Serum sialic acid in normals and in cancer patients. J Clin Chem Clin Biochem 22(10):647–651PubMed
10.
Van Pelt J, Van Bilsen DG, Kamerling JP, Vliegenthart JF (1988) Structural analysis of O-glycosidic type of sialyloligosaccharide-alditols derived from urinary glycopeptides of a sialidosis patient. Eur J Biochem 174(1):183–187PubMedCrossRef
11.
Lindberg G, Iso H, Råstam L, Lundblad A, Folsom AR (1997) Serum sialic acid and its correlates in community samples from Akita, Japan and Minneapolis, USA. Int J Epidemiol 26(1):58–63PubMedCrossRef
12.
Doğan H, Paşaoğlu H, Ekinciler OF, Tatlişen N (1992) A comparative study of total protein, total and lipid associated serum sialic acid levels in patients with Behçet’s disease and control groups. Acta Ophthalmol (Copenh) 70(6):790–794
13.
Sillanaukee P, Pönniö M, Jääskeläinen IP (1999) Occurrence of sialic acids in healthy humans and different disorders. Eur J Clin Invest 29(5):413–425PubMedCrossRef
14.
Rellier N, Ruggiero-Lopez D, Lecomte M, Lagarde M, Wiernsperger N (1999) In vitro and in vivo alterations of enzymatic glycosylation in diabetes. Life Sci 64(17):1571–1583PubMedCrossRef
15.
Mogensen CE (1984) Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med 310:356–360PubMedCrossRef
16.
Denny PC, Denny PA, Allerton SE (1983) Determination of sialic acid using 2-thiobarbituric acid in the absence of hazardous sodium arsenite. Clin Chim Acta 131(3):333–336PubMedCrossRef
17.
Ziegler D, Hutchinson H (1972) Coupled enzyme system for measuring viral neuraminidase activity. Appl Microb 23:1060
18.
Parkkinen J, Finne J (1983) Isolation and structural characterization of five major sialyloligosaccharides and a sialylglycopeptide from normal human urine. Eur J Biochem 136(2):355–361PubMedCrossRef
19.
Carter A, Martin NH (1962) Serum Sialic acid levels in health and disease. J Clin Pathol 15:69–72PubMedCrossRef
20.
Sonnez H, Ozturk ZG, Ulutin T, Domanc N, Kokoglu E (2000) Carbohydrate deficient transferring and sialidase level in coronary heart disease. Throm Res 99:311–315CrossRef
21.
Crook MA, Couchman S, Tutt P (1996) Plasma fibrinogen and its relationship to plasma sialic acid in non-insulin-dependent diabetes mellitus. Blood Coagul Fibrinolysis 7(6):586–589PubMedCrossRef
22.
Izumida Y, Seiyama A, Maeda N (1991) Erythrocyte aggregation: bridging by macromolecules and electrostatic repulsion by sialic acid. Biochem Biophys Acta 1067(2):221–226PubMedCrossRef
23.
Szkudelski T (2001) The mechanism of alloxan and streptozotocin action in β-cells of the rat pancreas. Physiol Res 50(6):537–546PubMed
24.
Ozen T, Nacitarhan S, Tuncer N (1995) Plasma and urine sialic acid in non-insulin dependent diabetes mellitus. Ann Clin Biochem 32(Pt 3):303–306
25.
Asami T, Tanaka A, Gunji T, Sakai K (1985) Elevated serum and urine sialic acid levels in renal disease of childhood. Clin Nephrol 23(3):112–119PubMed
26.
Ponnio M, Altho H, Nikkari ST, Olsson U, Rydberg U, Sillanaukee P (1999) Serum sialic acid in a random sample of the general population. Clin Chem 45(10):1842–1849PubMed
27.
Crook M, Collins D, Lumb P, Fogelman I, Treloar A (1998) The relationship between the female menopause and serum sialic acid, a known cardiovascular risk factor. Eur J Obstet and Gynecol Reprod Biol 76(2):185–187CrossRef
28.
Pickup JC, Mattock MB, Crook MA, Chusney GD, Burt D, Fitzgerald AP (1995) Serum sialic acid concentration and coronary heart disease in NIDDM. 1995. Diabetes Care 18(8):1100–1103PubMedCrossRef
29.
Giordano M, Ciarambino T, Gesuè L, Castellino P, De Simone M, Rinaldi G, D’Amora M, Zito G, Paolisso G, Coppola L (2009) The ratio between kidney volume and function increases with the progression of nephropathy in Type 2 diabetes. Clin Nephrol 72(4):247–251PubMed
Metadaten
Titel
Significance of serum and urine neuraminidase activity and serum and urine level of sialic acid in diabetic nephropathy
verfasst von
Jamshid Roozbeh
Ahmad Merat
Farahnaz Bodagkhan
Raha Afshariani
Hooman Yarmohammadi
Publikationsdatum
01.12.2011
Verlag
Springer Netherlands
Erschienen in
International Urology and Nephrology / Ausgabe 4/2011
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-010-9891-8

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