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01.09.2014 | Urology - Original Paper

Pathophysiology and animal modeling of underactive bladder

verfasst von: Pradeep Tyagi, Phillip P. Smith, George A. Kuchel, William C. de Groat, Lori A. Birder, Christopher J. Chermansky, Rosalyn M. Adam, Vincent Tse, Michael B. Chancellor, Naoki Yoshimura

Erschienen in: International Urology and Nephrology | Sonderheft 1/2014

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Abstract

While the symptomology of underactive bladder (UAB) may imply a primary dysfunction of the detrusor muscle, insights into pathophysiology indicate that both myogenic and neurogenic mechanisms need to be considered. Due to lack of proper animal models, the current understanding of the UAB pathophysiology is limited, and much of what is known about the clinical etiology of the condition has been derived from epidemiological data. We hereby review current state of the art in the understanding of the pathophysiology of and animal models used to study the UAB.

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Titel: Pathophysiology and animal modeling of underactive bladder
verfasst von: Pradeep Tyagi
Phillip P. Smith
George A. Kuchel
William C. de Groat
Lori A. Birder
Christopher J. Chermansky
Rosalyn M. Adam
Vincent Tse
Michael B. Chancellor
Naoki Yoshimura
Publikationsdatum: 01.09.2014
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe Sonderheft 1/2014
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-014-0808-9

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