Introduction
Materials and methods
Study population
Inclusion and exclusion criteria
Inclusion criteria
Exclusion criteria
Study evaluations
Statistical analysis
Results
BDI < 14 (n = 86) | BDI ≧ 14 (n = 43) |
P value | |
---|---|---|---|
Age (years) | 60.8 ± 13.9 | 66.7 ± 10.1 | 0.007* |
Male (%) | 50 (58.1%) | 25 (58.1%) | 1.000 |
Dialysis duration (years) | 4.8 ± 3.9 | 5.0 ± 4.3 | 0.721 |
Body mass index (kg/m2) | 23.1 ± 4.0 | 22.9 ± 3.1 | 0.775 |
Systolic blood pressure (mmHg) | 139.9 ± 19.6 | 136.3 ± 14.8 | 0.289 |
Diastolic blood pressure (mmHg) | 75.9 ± 8.4 | 75.4 ± 6.0 | 0.719 |
Hepatitis C infection (%) | 34 (39.5%) | 25 (58.1%) | 0.046* |
Diabetes (%) | 34 (39.5%) | 32 (74.4%) | <0.001* |
Albumin (g/dl) | 4.0 ± 0.4 | 3.7 ± 0.3 | <0.001* |
Hemoglobulin (gm/dl) | 10.4 ± 1.5 | 10.4 ± 1.7 | 1.000 |
ALT (U/L) | 18.8 ± 12.8 | 29.4 ± 56.3 | 0.231 |
Fasting blood glucose (mg/dl) | 113.5 ± 63.2 | 131.8 ± 71.6 | 0.141 |
Insulin (μIU/ml) | 23.5 ± 33.3 | 25.8 ± 37.2 | 0.726 |
C-peptide (ng/mL) | 13.6 ± 10.3 | 10.6 ± 6.5 | 0.044* |
HOMA-IR (μU/mL × mmol/L) | 6.2 ± 7.3 | 8.6 ± 10.9 | 0.140 |
iPTH (pg/mL) | 187.2 ± 171.5 | 165.1 ± 169.1 | 0.490 |
Ca × P (mg2/dL2) | 42.6 ± 13.9 | 42.2 ± 14.3 | 0.871 |
Total cholesterol (mg/dl) | 170.9 ± 38.3 | 157.9 ± 36.7 | 0.067 |
Triglyceride (mg/dl) | 167.4 ± 119.2 | 153.2 ± 123.1 | 0.528 |
HDL cholesterol (mg/dl) | 44.5 ± 13.6 | 44.2 ± 16.3 | 0.911 |
LDL cholesterol (mg/dl) | 97.8 ± 27.2 | 91.4 ± 23.7 | 0.196 |
Ln_hsCRP (mg/dL) | 1.33 ± 1.28 | 1.34 ± 1.30 | 0.991 |
Ln_Adiponectin (pg/mL) | 5.6 ± 0.3 | 5.7 ± 0.3 | 0.063 |
Ln_IL-6 (pg/mL) | 2.8 ± 1.0 | 3.0 ± 0.8 | 0.488 |
Ln_TNF-α (pg/mL) | 0.84 ± 0.96 | 0.82 ± 0.96 | 0.941 |
CCI | 2.5 ± 2.2 | 4.0 ± 2.3 | <0.001* |
ABI | 1.04 ± 0.20 | 0.96 ± 0.20 | 0.028* |
PWV (m/s) | 17.9 ± 5.7 | 18.4 ± 5.1 | 0.661 |
r
|
P value | |
---|---|---|
Age | 0.348 | <0.001* |
Body mass index (kg/m2) | −0.044 | 0.619 |
CCI | 0.387 | <0.001* |
Blood pressure
| ||
Systolic | −0.078 | 0.380 |
Diastolic | −0.064 | 0.474 |
Albumin (g/dl) | −0.399 | <0.001* |
Glucose | 0.090 | 0.311 |
Plasma lipids
| ||
LDL | −0.115 | 0.193 |
HDL | −0.050 | 0.575 |
Triglycerides | −0.121 | 0.172 |
Insulin (μIU/ml) | 0.044 | 0.626 |
C-peptide (ng/mL) | −0.175 | 0.047* |
HOMA-IR (μU/mL × mmol/L) | 0.076 | 0.391 |
ABI | −0.325 | <0.001* |
PWV (m/s) | 0.098 | 0.271 |
Ln_hsCRP (mg/dL) | 0.015 | 0.869 |
Ln_TNF-α (pg/mL) | −0.063 | 0.480 |
Ln_IL-6 (pg/mL) | 0.143 | 0.105 |
Ln_Adiponectin (pg/mL) | 0.160 | 0.069 |
Variables | Multivariate | |
---|---|---|
Coefficient (β) |
P value | |
Male gender | −0.849 | 0.593 |
Age (years) | 0.011 | 0.874 |
Diabetes | 3.594 | 0.040* |
Hepatitis C infection | 4.057 | 0.008* |
Albumin (g/dl) | −5.656 | 0.024* |
C-peptide | −0.292 | 0.002* |
ABI | −9.041 | 0.031* |
HOMA-IR | −0.015 | 0.914 |
Ln_hsCRP | −1.391 | 0.044* |
Insulin | 0.032 | 0.331 |
Ln_IL-6 | 1.126 | 0.231 |
Ln_TNF-α | −0.843 | 0.306 |