Skip to main content

24.01.2019 | Original Article

Evaluation of osseous changes in dental panoramic radiography of thalassemia patients using mandibular indexes and fractal size analysis

verfasst von: Seval Bayrak, Duygu Göller Bulut, Kaan Orhan, Enver Alper Sinanoğlu, Emine Şebnem Kurşun Çakmak, Melis Mısırlı, Handan Ankaralı

Erschienen in: Oral Radiology

Einloggen, um Zugang zu erhalten

Abstract

Objective

This study aimed to evaluate the radiomorphometric indexes and fractal dimension (FD) on dental panoramic radiography (DPR) of Thalassemia Major (TM) patients.

Methods

In 59 TM patients and in 59 healthy control subjects, mandibular cortical index (MCI), mandibular cortical width (MCW), panoramic mandibular index (PMI), and FD of four different regions (FD1-4) were evaluated and compared using DPRs.

Results

The distribution of MCI in TM patients was similar to control subjects (p > 0.05). The mean MCW was significantly lower in TM patients (p = 0.001). There was no significant difference in PMI between TM patients and control subjects. The mean of FD measured in the supracortical area above the angle of mandible (FD2), in the anterior to the mental foramen (FD4) and mean FD of four different regions was significantly lower in TM patients (p = 0.003, p = 0.001, and p = 0.014, respectively).

Conclusions

The radiomorphometric indices and fractal dimensions evaluated in the panoramic radiograph are capable of identifying thalassemia patients’ jaw bone, and the results of DPR scanning can be used to refer these patients to appropriate medical investigation.
Literatur
1.
Zurück zum Zitat Toman HA, Nasir A, Hassan R, Hassan R. Skeletal, dentoalveolar, and soft tissue cephalometric measurements of Malay transfusion-dependent thalassaemia patients. Eur J Orthod. 2011;33:700–4.CrossRef Toman HA, Nasir A, Hassan R, Hassan R. Skeletal, dentoalveolar, and soft tissue cephalometric measurements of Malay transfusion-dependent thalassaemia patients. Eur J Orthod. 2011;33:700–4.CrossRef
2.
Zurück zum Zitat Morabito N, Lasco A, Gaudio A, Crisafulli A, Di Pietro C, Meo A, et al. Bisphosphonates in the treatment of thalassemia-induced osteoporosis. Osteoporos Int. 2002;13:644–9.CrossRef Morabito N, Lasco A, Gaudio A, Crisafulli A, Di Pietro C, Meo A, et al. Bisphosphonates in the treatment of thalassemia-induced osteoporosis. Osteoporos Int. 2002;13:644–9.CrossRef
3.
Zurück zum Zitat Voskaridou E, Anagnostopoulos A, Konstantopoulos K, Stoupa E, Spyropoulou E, Kiamouris C, et al. Zoledronic acid for the treatment of osteoporosis in patients with beta-thalassemia: results from a single-center, randomized, placebo-controlled trial. Haematologica. 2006;91:1193–202.PubMed Voskaridou E, Anagnostopoulos A, Konstantopoulos K, Stoupa E, Spyropoulou E, Kiamouris C, et al. Zoledronic acid for the treatment of osteoporosis in patients with beta-thalassemia: results from a single-center, randomized, placebo-controlled trial. Haematologica. 2006;91:1193–202.PubMed
4.
Zurück zum Zitat Mamtani M, Kulkarni H. Bone recovery after zoledronate therapy in thalassemia-induced osteoporosis: a meta-analysis and systematic review. Osteoporos Int. 2010;21:183–7.CrossRef Mamtani M, Kulkarni H. Bone recovery after zoledronate therapy in thalassemia-induced osteoporosis: a meta-analysis and systematic review. Osteoporos Int. 2010;21:183–7.CrossRef
5.
Zurück zum Zitat Pennisi P, Pizzarelli G, Spina M, Riccobene S, Fiore CE. Quantitative ultrasound of bone and clodronate effects in thalassemia-induced osteoporosis. J Bone Miner Metab. 2003;21:402–8.CrossRef Pennisi P, Pizzarelli G, Spina M, Riccobene S, Fiore CE. Quantitative ultrasound of bone and clodronate effects in thalassemia-induced osteoporosis. J Bone Miner Metab. 2003;21:402–8.CrossRef
6.
Zurück zum Zitat Dagistan S, Bilge OM. Comparison of antegonial index, mental index, panoramic mandibular index and mandibular cortical index values in the panoramic radiographs of normal males and male patients with osteoporosis. Dentomaxillofac Radiol. 2010;39:290–4.CrossRef Dagistan S, Bilge OM. Comparison of antegonial index, mental index, panoramic mandibular index and mandibular cortical index values in the panoramic radiographs of normal males and male patients with osteoporosis. Dentomaxillofac Radiol. 2010;39:290–4.CrossRef
7.
Zurück zum Zitat Ferreira Leite A, de Souza Figueiredo PT, Ramos Barra F, Santos de Melo N, de Paula AP. Relationships between mandibular cortical indexes, bone mineral density, and osteoporotic fractures in Brazilian men over 60 years old. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112:648–56.CrossRef Ferreira Leite A, de Souza Figueiredo PT, Ramos Barra F, Santos de Melo N, de Paula AP. Relationships between mandibular cortical indexes, bone mineral density, and osteoporotic fractures in Brazilian men over 60 years old. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112:648–56.CrossRef
8.
Zurück zum Zitat Demiralp K, Kurşun-Çakmak E, Bayrak S, Akbulut N, Atakan C, Orhan K. Trabecular structure designation using fractal analysis technique on panoramic radiographs of patients with bisphosphonate intake: a preliminary study. Oral Radiol. 2019;35:23–8.CrossRef Demiralp K, Kurşun-Çakmak E, Bayrak S, Akbulut N, Atakan C, Orhan K. Trabecular structure designation using fractal analysis technique on panoramic radiographs of patients with bisphosphonate intake: a preliminary study. Oral Radiol. 2019;35:23–8.CrossRef
10.
Zurück zum Zitat Klemetti E, Kolmakow S. Morphology of the mandibular cortex on panoramic radiographs as an indicator of bone quality. Dentomaxillofac Radiol. 1997;26:22–5.CrossRef Klemetti E, Kolmakow S. Morphology of the mandibular cortex on panoramic radiographs as an indicator of bone quality. Dentomaxillofac Radiol. 1997;26:22–5.CrossRef
11.
Zurück zum Zitat White SC, Rudolph DJ. Alterations of the trabecular pattern of the jaws in patients with osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88:628–35.CrossRef White SC, Rudolph DJ. Alterations of the trabecular pattern of the jaws in patients with osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88:628–35.CrossRef
12.
Zurück zum Zitat Arsan B, Kose TE, Cene E, Ozcan I. Assessment of the trabecular structure of mandibular condyles in patients with temporomandibular disorders using fractal analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123:382–91.CrossRef Arsan B, Kose TE, Cene E, Ozcan I. Assessment of the trabecular structure of mandibular condyles in patients with temporomandibular disorders using fractal analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123:382–91.CrossRef
13.
Zurück zum Zitat Apolinario AC, Sindeaux R, de Souza Figueiredo PT, Guimaraes AT, Acevedo AC, Castro LC, et al. Dental panoramic indices and fractal dimension measurements in osteogenesis imperfecta children under pamidronate treatment. Dentomaxillofac Radiol. 2016;45:20150400.CrossRef Apolinario AC, Sindeaux R, de Souza Figueiredo PT, Guimaraes AT, Acevedo AC, Castro LC, et al. Dental panoramic indices and fractal dimension measurements in osteogenesis imperfecta children under pamidronate treatment. Dentomaxillofac Radiol. 2016;45:20150400.CrossRef
14.
Zurück zum Zitat Gumussoy I, Miloglu O, Cankaya E, Bayrakdar IS. Fractal properties of the trabecular pattern of the mandible in chronic renal failure. Dentomaxillofac Radiol. 2016;45:20150389.CrossRef Gumussoy I, Miloglu O, Cankaya E, Bayrakdar IS. Fractal properties of the trabecular pattern of the mandible in chronic renal failure. Dentomaxillofac Radiol. 2016;45:20150389.CrossRef
15.
Zurück zum Zitat Sindeaux R, Figueiredo PT, de Melo NS, Guimaraes AT, Lazarte L, Pereira FB, et al. Fractal dimension and mandibular cortical width in normal and osteoporotic men and women. Maturitas. 2014;77:142–8.CrossRef Sindeaux R, Figueiredo PT, de Melo NS, Guimaraes AT, Lazarte L, Pereira FB, et al. Fractal dimension and mandibular cortical width in normal and osteoporotic men and women. Maturitas. 2014;77:142–8.CrossRef
16.
Zurück zum Zitat Ledgerton D, Horner K, Devlin H, Worthington H. Panoramic mandibular index as a radiomorphometric tool: an assessment of precision. Dentomaxillofac Radiol. 1997;26:95–100.CrossRef Ledgerton D, Horner K, Devlin H, Worthington H. Panoramic mandibular index as a radiomorphometric tool: an assessment of precision. Dentomaxillofac Radiol. 1997;26:95–100.CrossRef
17.
Zurück zum Zitat Benson BW, Prihoda TJ, Glass BJ. Variations in adult cortical bone mass as measured by a panoramic mandibular index. Oral Surg Oral Med Oral Pathol. 1991;71:349–56.CrossRef Benson BW, Prihoda TJ, Glass BJ. Variations in adult cortical bone mass as measured by a panoramic mandibular index. Oral Surg Oral Med Oral Pathol. 1991;71:349–56.CrossRef
18.
Zurück zum Zitat Carmo JZB, Medeiros SF. Mandibular inferior cortex erosion on dental panoramic radiograph as a sign of low bone mineral density in postmenopausal women. Rev Bras Ginecol Obstet. 2017;39:663–9.CrossRef Carmo JZB, Medeiros SF. Mandibular inferior cortex erosion on dental panoramic radiograph as a sign of low bone mineral density in postmenopausal women. Rev Bras Ginecol Obstet. 2017;39:663–9.CrossRef
19.
Zurück zum Zitat Morabito N, Gaudio A, Lasco A, Atteritano M, Pizzoleo MA, Cincotta M, et al. Osteoprotegerin and RANKL in the pathogenesis of thalassemia-induced osteoporosis: new pieces of the puzzle. J Bone Miner Res. 2004;19:722–7.CrossRef Morabito N, Gaudio A, Lasco A, Atteritano M, Pizzoleo MA, Cincotta M, et al. Osteoprotegerin and RANKL in the pathogenesis of thalassemia-induced osteoporosis: new pieces of the puzzle. J Bone Miner Res. 2004;19:722–7.CrossRef
20.
Zurück zum Zitat Voskaridou E, Kyrtsonis MC, Terpos E, Skordili M, Theodoropoulos I, Bergele A, et al. Bone resorption is increased in young adults with thalassaemia major. Br J Haematol. 2001;112:36–41.CrossRef Voskaridou E, Kyrtsonis MC, Terpos E, Skordili M, Theodoropoulos I, Bergele A, et al. Bone resorption is increased in young adults with thalassaemia major. Br J Haematol. 2001;112:36–41.CrossRef
21.
Zurück zum Zitat Lasco A, Morabito N, Gaudio A, Buemi M, Wasniewska M, Frisina N. Effects of hormonal replacement therapy on bone metabolism in young adults with beta-thalassemia major. Osteoporos Int. 2001;12:570–5.CrossRef Lasco A, Morabito N, Gaudio A, Buemi M, Wasniewska M, Frisina N. Effects of hormonal replacement therapy on bone metabolism in young adults with beta-thalassemia major. Osteoporos Int. 2001;12:570–5.CrossRef
22.
Zurück zum Zitat Mostafa RA, Arnout EA, Abo El-Fotouh MM. Feasibility of cone beam computed tomography radiomorphometric analysis and fractal dimension in assessment of postmenopausal osteoporosis in correlation with dual X-ray absorptiometry. Dentomaxillofac Radiol. 2016;45:20160212.CrossRef Mostafa RA, Arnout EA, Abo El-Fotouh MM. Feasibility of cone beam computed tomography radiomorphometric analysis and fractal dimension in assessment of postmenopausal osteoporosis in correlation with dual X-ray absorptiometry. Dentomaxillofac Radiol. 2016;45:20160212.CrossRef
23.
Zurück zum Zitat Southard TE, Southard KA, Krizan KE, Hillis SL, Haller JW, Keller J, et al. Mandibular bone density and fractal dimension in rabbits with induced osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2000;89:244–9. Southard TE, Southard KA, Krizan KE, Hillis SL, Haller JW, Keller J, et al. Mandibular bone density and fractal dimension in rabbits with induced osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2000;89:244–9.
24.
Zurück zum Zitat Alonso MBC, Cortes AR, Camargo AJ, Arita ES, Haiter-Neto F, Watanabe PCA. Assessment of panoramic radiomorphometric indices of the mandible in a brazilian population. ISRN Rheumatol. 2011;2011:854287.PubMedPubMedCentral Alonso MBC, Cortes AR, Camargo AJ, Arita ES, Haiter-Neto F, Watanabe PCA. Assessment of panoramic radiomorphometric indices of the mandible in a brazilian population. ISRN Rheumatol. 2011;2011:854287.PubMedPubMedCentral
25.
Zurück zum Zitat Lee K, Taguchi A, Ishii K, Suei Y, Fujita M, Nakamoto T, et al. Visual assessment of the mandibular cortex on panoramic radiographs to identify postmenopausal women with low bone mineral densities. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100:226–31.CrossRef Lee K, Taguchi A, Ishii K, Suei Y, Fujita M, Nakamoto T, et al. Visual assessment of the mandibular cortex on panoramic radiographs to identify postmenopausal women with low bone mineral densities. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100:226–31.CrossRef
26.
Zurück zum Zitat Gulsahi A, Yuzugullu B, Imirzalioglu P, Genc Y. Assessment of panoramic radiomorphometric indices in Turkish patients of different age groups, gender and dental status. Dentomaxillofac Radiol. 2008;37:288–92.CrossRef Gulsahi A, Yuzugullu B, Imirzalioglu P, Genc Y. Assessment of panoramic radiomorphometric indices in Turkish patients of different age groups, gender and dental status. Dentomaxillofac Radiol. 2008;37:288–92.CrossRef
27.
Zurück zum Zitat Ledgerton D, Horner K, Devlin H, Worthington H. Radiomorphometric indices of the mandible in a British female population. Dentomaxillofac Radiol. 1999;28:173–81.CrossRef Ledgerton D, Horner K, Devlin H, Worthington H. Radiomorphometric indices of the mandible in a British female population. Dentomaxillofac Radiol. 1999;28:173–81.CrossRef
28.
Zurück zum Zitat Amorim MA, Takayama L, Jorgetti V, Pereira RM. Comparative study of axial and femoral bone mineral density and parameters of mandibular bone quality in patients receiving dental implants. Osteoporos Int. 2007;18:703–9.CrossRef Amorim MA, Takayama L, Jorgetti V, Pereira RM. Comparative study of axial and femoral bone mineral density and parameters of mandibular bone quality in patients receiving dental implants. Osteoporos Int. 2007;18:703–9.CrossRef
29.
Zurück zum Zitat Demirbas AK, Ergun S, Guneri P, Aktener BO, Boyacioglu H. Mandibular bone changes in sickle cell anemia: fractal analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:e41-8.CrossRef Demirbas AK, Ergun S, Guneri P, Aktener BO, Boyacioglu H. Mandibular bone changes in sickle cell anemia: fractal analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:e41-8.CrossRef
30.
Zurück zum Zitat Updike SX, Nowzari H. Fractal analysis of dental radiographs to detect periodontitis-induced trabecular changes. J Periodontal Res. 2008;43:658–64.CrossRef Updike SX, Nowzari H. Fractal analysis of dental radiographs to detect periodontitis-induced trabecular changes. J Periodontal Res. 2008;43:658–64.CrossRef
31.
Zurück zum Zitat Chen SK, Oviir T, Lin CH, Leu LJ, Cho BH, Hollender L. Digital imaging analysis with mathematical morphology and fractal dimension for evaluation of periapical lesions following endodontic treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100:467–72.CrossRef Chen SK, Oviir T, Lin CH, Leu LJ, Cho BH, Hollender L. Digital imaging analysis with mathematical morphology and fractal dimension for evaluation of periapical lesions following endodontic treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100:467–72.CrossRef
32.
Zurück zum Zitat Orhan K, Delilbasi C, Paksoy C. Magnetic resonance imaging evaluation of mandibular condyle bone marrow and temporomandibular joint disc signal intensity in anaemia patients. Dentomaxillofac Radiol. 2009;38(5):247–54.CrossRef Orhan K, Delilbasi C, Paksoy C. Magnetic resonance imaging evaluation of mandibular condyle bone marrow and temporomandibular joint disc signal intensity in anaemia patients. Dentomaxillofac Radiol. 2009;38(5):247–54.CrossRef
33.
Zurück zum Zitat Baykul T, Aydin MA, Nasir S. Avascular necrosis of the mandibular condyle causing fibrous ankylosis of the temporomandibular joint in sickle cell anemia. J Craniofac Surg. 2004;15:1052–6.CrossRef Baykul T, Aydin MA, Nasir S. Avascular necrosis of the mandibular condyle causing fibrous ankylosis of the temporomandibular joint in sickle cell anemia. J Craniofac Surg. 2004;15:1052–6.CrossRef
34.
Zurück zum Zitat el-Sabbagh AM, Kamel M. Avascular necrosis of temporomandibular joint in sickle cell disease. Clin Rheumatol. 1989;8:393–7.CrossRef el-Sabbagh AM, Kamel M. Avascular necrosis of temporomandibular joint in sickle cell disease. Clin Rheumatol. 1989;8:393–7.CrossRef
Metadaten
Titel
Evaluation of osseous changes in dental panoramic radiography of thalassemia patients using mandibular indexes and fractal size analysis
verfasst von
Seval Bayrak
Duygu Göller Bulut
Kaan Orhan
Enver Alper Sinanoğlu
Emine Şebnem Kurşun Çakmak
Melis Mısırlı
Handan Ankaralı
Publikationsdatum
24.01.2019
Verlag
Springer Singapore
Erschienen in
Oral Radiology
Print ISSN: 0911-6028
Elektronische ISSN: 1613-9674
DOI
https://doi.org/10.1007/s11282-019-00372-7

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Klinik aktuell Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärztinnen und Psychotherapeuten.

Parodontalbehandlung verbessert Prognose bei Katheterablation

19.04.2024 Vorhofflimmern Nachrichten

Werden Personen mit Vorhofflimmern in der Blanking-Periode nach einer Katheterablation gegen eine bestehende Parodontitis behandelt, verbessert dies die Erfolgsaussichten. Dafür sprechen die Resultate einer prospektiven Untersuchung.

Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Zahnmedizin und bleiben Sie gut informiert – ganz bequem per eMail.