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01.07.2012 | Original Paper

Anti-hyperlipidemic constituents from the bark of Shorea roxburghii

verfasst von: Toshio Morikawa, Saowanee Chaipech, Hisashi Matsuda, Makoto Hamao, Yohei Umeda, Hiroki Sato, Haruka Tamura, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2012

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Abstract

The methanol extract from the bark of Shorea roxburghii (Dipterocarpaceae, “Phayom” in Thai) was found to suppress plasma triglyceride elevation in olive oil-treated mice, and also to inhibit pancreatic lipase activity (IC₅₀ = 31.6 μg/ml). From the extract, two new 3-acetyl-4-phenyl-3,4-dihydroisocoumarins, phayomphenols A₁ (1) and A₂ (2) were isolated, together with 22 known compounds. The structures of 1 and 2 were elucidated on the basis of chemical and spectroscopic evidence, including X-ray crystallographic analysis. Among the isolates, several oligostilbenoids, including (−)-hopeaphenol (3) and (+)-isohopeaphenol (4), showed inhibitory effects on plasma triglyceride elevation at a dose of 200 mg/kg p.o. and pancreatic lipase inhibitory activity (IC₅₀ = 32.9 and 26.5 μM, respectively).

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Titel: Anti-hyperlipidemic constituents from the bark of Shorea roxburghii
verfasst von: Toshio Morikawa
Saowanee Chaipech
Hisashi Matsuda
Makoto Hamao
Yohei Umeda
Hiroki Sato
Haruka Tamura
Kiyofumi Ninomiya
Masayuki Yoshikawa
Yutana Pongpiriyadacha
Takao Hayakawa
Osamu Muraoka
Publikationsdatum: 01.07.2012
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 3/2012
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-011-0619-6

Springer Medizin

Abstract

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