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29.06.2016 | Note

Anti-melanin deposition activity of ceramicines from Chisocheton ceramicus

verfasst von: Chie Iijima, Chin Piow Wong, Alfarius Eko Nugroho, Yayoi Sotozono, Saki Someya, Yusuke Hirasawa, Toshio Kaneda, A. Hamid A. Hadi, Hiroshi Morita

Erschienen in: Journal of Natural Medicines | Ausgabe 4/2016

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Abstract

The ceramicines, a series of limonoids from Chisocheton ceramicus (Meliaceae), were evaluated for anti-melanin deposition activity on α-melanocyte stimulating hormone (α-MSH) and 3-isobutyl-1-methylxanthine (IBMX)-treated B16-F10 melanoma cell, and several ceramicines were found to be active. The structure–activity relationship of ceramicines as anti-melanin deposition inhibitors was deduced. Furthermore, the mechanism of anti-melanin deposition activity of ceramicine B, a major constituent of C. ceramicus that showed potent anti-melanin deposition activity, was investigated. Tyrosinase enzymatic activity and tyrosinase mRNA expression were not affected by ceramicine B. The anti-melanin deposition activity of ceramicine B was shown to be related to the downregulation of tyrosinase protein expression. These results suggest that ceramicines have potential to be used as depigmentation agents.

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Titel: Anti-melanin deposition activity of ceramicines from Chisocheton ceramicus
verfasst von: Chie Iijima
Chin Piow Wong
Alfarius Eko Nugroho
Yayoi Sotozono
Saki Someya
Yusuke Hirasawa
Toshio Kaneda
A. Hamid A. Hadi
Hiroshi Morita
Publikationsdatum: 29.06.2016
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 4/2016
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-016-1016-y

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Anti-melanin deposition activity of ceramicines from Chisocheton ceramicus

Abstract

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Abstract

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