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Erschienen in: Journal of General Internal Medicine 1/2016

01.01.2016 | Review Paper

Vegetarian Diets and Weight Reduction: a Meta-Analysis of Randomized Controlled Trials

verfasst von: Ru-Yi Huang, MD, MPH, Chuan-Chin Huang, ScD, Frank B. Hu, MD, PhD, Jorge E. Chavarro, MD, ScD

Erschienen in: Journal of General Internal Medicine | Ausgabe 1/2016

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ABSTRACT

Background

Vegetarian diets may promote weight loss, but evidence remains inconclusive.

Methods

PubMed, EMBASE and UpToDate databases were searched through September 22, 2014, and investigators extracted data regarding study characteristics and assessed study quality among selected randomized clinical trials. Population size, demographic (i.e., gender and age) and anthropometric (i.e., body mass index) characteristics, types of interventions, follow-up periods, and trial quality (Jadad score) were recorded. The net changes in body weight of subjects were analyzed and pooled after assessing heterogeneity with a random effects model. Subgroup analysis was performed based on type of vegetarian diet, type of energy restriction, study population, and follow-up period.

Results

Twelve randomized controlled trials were included, involving a total of 1151 subjects who received the intervention over a median duration of 18 weeks. Overall, individuals assigned to the vegetarian diet groups lost significantly more weight than those assigned to the non-vegetarian diet groups (weighted mean difference, −2.02 kg; 95 % confidence interval [CI]: −2.80 to −1.23). Subgroup analysis detected significant weight reduction in subjects consuming a vegan diet (−2.52 kg; 95 % CI: −3.02 to −1.98) and, to a lesser extent, in those given lacto-ovo-vegetarian diets (−1.48 kg; 95 % CI: −3.43 to 0.47). Studies on subjects consuming vegetarian diets with energy restriction (ER) revealed a significantly greater weight reduction (−2.21 kg; 95 % CI: −3.31 to −1.12) than those without ER (−1.66 kg; 95 % CI: −2.85 to −0.48). The weight loss for subjects with follow-up of <1 year was greater (−2.05 kg; 95 % CI: −2.85 to −1.25) than those with follow-up of ≥1 year (−1.13 kg; 95 % CI: −2.04 to −0.21).

Conclusions

Vegetarian diets appeared to have significant benefits on weight reduction compared to non-vegetarian diets. Further long-term trials are needed to investigate the effects of vegetarian diets on body weight control.
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Literatur
1.
Zurück zum Zitat Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014. doi:10.1016/S0140-6736(14)60460-8. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014. doi:10.​1016/​S0140-6736(14)60460-8.
2.
Zurück zum Zitat Hu FB, ed. Obesity Epidemiology. 1st ed. Boston: Oxford University Press; 2008. Hu FB, ed. Obesity Epidemiology. 1st ed. Boston: Oxford University Press; 2008.
3.
Zurück zum Zitat Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2224–60. doi:10.1016/S0140-6736(12)61766-8.PubMedPubMedCentralCrossRef Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2224–60. doi:10.​1016/​S0140-6736(12)61766-8.PubMedPubMedCentralCrossRef
4.
Zurück zum Zitat Wang Y, Beydoun MA. The obesity epidemic in the United States–gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Epidemiol Rev. 2007;29:6–28. doi:10.1093/epirev/mxm007.PubMedCrossRef Wang Y, Beydoun MA. The obesity epidemic in the United States–gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Epidemiol Rev. 2007;29:6–28. doi:10.​1093/​epirev/​mxm007.PubMedCrossRef
5.
Zurück zum Zitat Finkelstein EA, Fiebelkorn IC, Wang G. National medical spending attributable to overweight and obesity: how much, and who's paying? Health Aff (Millwood). 2003;(Suppl Web Exclusives):W3-219–26. Finkelstein EA, Fiebelkorn IC, Wang G. National medical spending attributable to overweight and obesity: how much, and who's paying? Health Aff (Millwood). 2003;(Suppl Web Exclusives):W3-219–26.
7.
Zurück zum Zitat Mishra S, Xu J, Agarwal U, Gonzales J, Levin S, Barnard ND. A multicenter randomized controlled trial of a plant-based nutrition program to reduce body weight and cardiovascular risk in the corporate setting: the GEICO study. Eur J Clin Nutr. 2013;67(7):718–24. doi:10.1038/ejcn.2013.92.PubMedPubMedCentralCrossRef Mishra S, Xu J, Agarwal U, Gonzales J, Levin S, Barnard ND. A multicenter randomized controlled trial of a plant-based nutrition program to reduce body weight and cardiovascular risk in the corporate setting: the GEICO study. Eur J Clin Nutr. 2013;67(7):718–24. doi:10.​1038/​ejcn.​2013.​92.PubMedPubMedCentralCrossRef
8.
Zurück zum Zitat Kahleova H, Matoulek M, Bratova M, Malinska H, Kazdova L, Hill M, et al. Vegetarian diet-induced increase in linoleic acid in serum phospholipids is associated with improved insulin sensitivity in subjects with type 2 diabetes. Nutr Diabetes. 2013;3, e75. doi:10.1038/nutd.2013.12.PubMedPubMedCentralCrossRef Kahleova H, Matoulek M, Bratova M, Malinska H, Kazdova L, Hill M, et al. Vegetarian diet-induced increase in linoleic acid in serum phospholipids is associated with improved insulin sensitivity in subjects with type 2 diabetes. Nutr Diabetes. 2013;3, e75. doi:10.​1038/​nutd.​2013.​12.PubMedPubMedCentralCrossRef
9.
10.
Zurück zum Zitat Burke LE, Warziski M, Styn MA, Music E, Hudson AG, Sereika SM. A randomized clinical trial of a standard versus vegetarian diet for weight loss: the impact of treatment preference. Int J Obes (Lond). 2008;32(1):166–76. doi:10.1038/sj.ijo.0803706.CrossRef Burke LE, Warziski M, Styn MA, Music E, Hudson AG, Sereika SM. A randomized clinical trial of a standard versus vegetarian diet for weight loss: the impact of treatment preference. Int J Obes (Lond). 2008;32(1):166–76. doi:10.​1038/​sj.​ijo.​0803706.CrossRef
11.
Zurück zum Zitat Turner-McGrievy GM, Barnard ND, Scialli AR. A two-year randomized weight loss trial comparing a vegan diet to a more moderate low-fat diet. Obesity. 2007;15(9):2276–81.PubMedCrossRef Turner-McGrievy GM, Barnard ND, Scialli AR. A two-year randomized weight loss trial comparing a vegan diet to a more moderate low-fat diet. Obesity. 2007;15(9):2276–81.PubMedCrossRef
12.
Zurück zum Zitat Mahon AK, Flynn MG, Stewart LK, McFarlin BK, Iglay HB, Mattes RD, et al. Protein intake during energy restriction: effects on body composition and markers of metabolic and cardiovascular health in postmenopausal women. J Am Coll Nutr. 2007;26(2):182–9.PubMedPubMedCentralCrossRef Mahon AK, Flynn MG, Stewart LK, McFarlin BK, Iglay HB, Mattes RD, et al. Protein intake during energy restriction: effects on body composition and markers of metabolic and cardiovascular health in postmenopausal women. J Am Coll Nutr. 2007;26(2):182–9.PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat Gardner CD, Kiazand A, Alhassan S, Kim S, Stafford RS, Balise RR, et al. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA. 2007;297(9):969–77. doi:10.1001/jama.297.9.969.PubMedCrossRef Gardner CD, Kiazand A, Alhassan S, Kim S, Stafford RS, Balise RR, et al. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA. 2007;297(9):969–77. doi:10.​1001/​jama.​297.​9.​969.PubMedCrossRef
14.
Zurück zum Zitat Barnard ND, Cohen J, Jenkins DJ, Turner-McGrievy G, Gloede L, Jaster B, et al. A low-fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes. Diabetes Care. 2006;29(8):1777–83. doi:10.2337/dc06-0606.PubMedCrossRef Barnard ND, Cohen J, Jenkins DJ, Turner-McGrievy G, Gloede L, Jaster B, et al. A low-fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes. Diabetes Care. 2006;29(8):1777–83. doi:10.​2337/​dc06-0606.PubMedCrossRef
15.
Zurück zum Zitat Dansinger ML, Gleason JA, Griffith JL, Selker HP, Schaefer EJ. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA. 2005;293(1):43–53. doi:10.1001/jama.293.1.43.PubMedCrossRef Dansinger ML, Gleason JA, Griffith JL, Selker HP, Schaefer EJ. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA. 2005;293(1):43–53. doi:10.​1001/​jama.​293.​1.​43.PubMedCrossRef
17.
Zurück zum Zitat Nicholson AS, Sklar M, Barnard ND, Gore S, Sullivan R, Browning S. Toward improved management of NIDDM: a randomized, controlled, pilot intervention using a lowfat, vegetarian diet. Prev Med. 1999;29(2):87–91. doi:10.1006/pmed.1999.0529.PubMedCrossRef Nicholson AS, Sklar M, Barnard ND, Gore S, Sullivan R, Browning S. Toward improved management of NIDDM: a randomized, controlled, pilot intervention using a lowfat, vegetarian diet. Prev Med. 1999;29(2):87–91. doi:10.​1006/​pmed.​1999.​0529.PubMedCrossRef
18.
Zurück zum Zitat Skoldstam L. Fasting and vegan diet in rheumatoid arthritis. Scand J Rheumatol. 1986;15(2):219–21.PubMedCrossRef Skoldstam L. Fasting and vegan diet in rheumatoid arthritis. Scand J Rheumatol. 1986;15(2):219–21.PubMedCrossRef
19.
Zurück zum Zitat Prescott SL, Jenner DA, Beilin LJ, Margetts BM, Vandongen R. A randomized controlled trial of the effect on blood pressure of dietary non-meat protein versus meat protein in normotensive omnivores. Clin Sci (Lond). 1988;74(6):665–72.CrossRef Prescott SL, Jenner DA, Beilin LJ, Margetts BM, Vandongen R. A randomized controlled trial of the effect on blood pressure of dietary non-meat protein versus meat protein in normotensive omnivores. Clin Sci (Lond). 1988;74(6):665–72.CrossRef
21.
Zurück zum Zitat Higgins JPT, Green S, eds. Cochrane Handbook For Systematic Reviews of Interventions. Chichester, United Kingdom: Wiley-Blackwell; 2008. Higgins JPT, Green S, eds. Cochrane Handbook For Systematic Reviews of Interventions. Chichester, United Kingdom: Wiley-Blackwell; 2008.
22.
Zurück zum Zitat DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177–88.PubMedCrossRef DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177–88.PubMedCrossRef
23.
Zurück zum Zitat Skoldstam L, Larsson L, Lindstrom FD. Effect of fasting and lactovegetarian diet on rheumatoid arthritis. Scand J Rheumatol. 1979;8(4):249–55.PubMedCrossRef Skoldstam L, Larsson L, Lindstrom FD. Effect of fasting and lactovegetarian diet on rheumatoid arthritis. Scand J Rheumatol. 1979;8(4):249–55.PubMedCrossRef
24.
Zurück zum Zitat Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1–12.PubMedCrossRef Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1–12.PubMedCrossRef
25.
27.
Zurück zum Zitat Newby PK, Tucker KL, Wolk A. Risk of overweight and obesity among semivegetarian, lactovegetarian, and vegan women. Am J Clin Nutr. 2005;81(6):1267–74.PubMed Newby PK, Tucker KL, Wolk A. Risk of overweight and obesity among semivegetarian, lactovegetarian, and vegan women. Am J Clin Nutr. 2005;81(6):1267–74.PubMed
29.
Zurück zum Zitat Ornish D, Brown SE, Scherwitz LW, Billings JH, Armstrong WT, Ports TA, et al. Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart. Trial Lancet. 1990;336(8708):129–33.PubMedCrossRef Ornish D, Brown SE, Scherwitz LW, Billings JH, Armstrong WT, Ports TA, et al. Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart. Trial Lancet. 1990;336(8708):129–33.PubMedCrossRef
30.
Zurück zum Zitat Koh-Banerjee P, Rimm EB. Whole grain consumption and weight gain: a review of the epidemiological evidence, potential mechanisms and opportunities for future research. Proc Nutr Soc. 2003;62(1):25–9. doi:10.1079/PNS2002232.PubMedCrossRef Koh-Banerjee P, Rimm EB. Whole grain consumption and weight gain: a review of the epidemiological evidence, potential mechanisms and opportunities for future research. Proc Nutr Soc. 2003;62(1):25–9. doi:10.​1079/​PNS2002232.PubMedCrossRef
31.
Zurück zum Zitat Ludwig DS, Pereira MA, Kroenke CH, Hilner JE, Van Horn L, Slattery ML, et al. Dietary fiber, weight gain, and cardiovascular disease risk factors in young adults. JAMA. 1999;282(16):1539–46.PubMedCrossRef Ludwig DS, Pereira MA, Kroenke CH, Hilner JE, Van Horn L, Slattery ML, et al. Dietary fiber, weight gain, and cardiovascular disease risk factors in young adults. JAMA. 1999;282(16):1539–46.PubMedCrossRef
32.
Zurück zum Zitat Liu S, Willett WC, Manson JE, Hu FB, Rosner B, Colditz G. Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women. Am J Clin Nutr. 2003;78(5):920–7.PubMed Liu S, Willett WC, Manson JE, Hu FB, Rosner B, Colditz G. Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women. Am J Clin Nutr. 2003;78(5):920–7.PubMed
33.
Zurück zum Zitat He K, Hu FB, Colditz GA, Manson JE, Willett WC, Liu S. Changes in intake of fruits and vegetables in relation to risk of obesity and weight gain among middle-aged women. Int J Obes Relat Metab Disord. 2004;28(12):1569–74. doi:10.1038/sj.ijo.0802795.PubMedCrossRef He K, Hu FB, Colditz GA, Manson JE, Willett WC, Liu S. Changes in intake of fruits and vegetables in relation to risk of obesity and weight gain among middle-aged women. Int J Obes Relat Metab Disord. 2004;28(12):1569–74. doi:10.​1038/​sj.​ijo.​0802795.PubMedCrossRef
34.
Zurück zum Zitat Pittler MH, Ernst E. Guar gum for body weight reduction: meta-analysis of randomized trials. Am J Med. 2001;110(9):724–30.PubMedCrossRef Pittler MH, Ernst E. Guar gum for body weight reduction: meta-analysis of randomized trials. Am J Med. 2001;110(9):724–30.PubMedCrossRef
Metadaten
Titel
Vegetarian Diets and Weight Reduction: a Meta-Analysis of Randomized Controlled Trials
verfasst von
Ru-Yi Huang, MD, MPH
Chuan-Chin Huang, ScD
Frank B. Hu, MD, PhD
Jorge E. Chavarro, MD, ScD
Publikationsdatum
01.01.2016
Verlag
Springer US
Erschienen in
Journal of General Internal Medicine / Ausgabe 1/2016
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-015-3390-7

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